Výsledky vyhledávání - "J I Smallwood"

Protein kinase C translocation in intact vascular smooth muscle strips

Autor: Howard Rasmussen, J I Smallwood, H Haller

Publikováno v: Biochemical Journal. 270:375-381

Using intact muscle strips from the bovine carotid artery, the time course of translocation of protein kinase C (PKC) from the cytosol to the membrane fraction was measured in response to various agonists that induce contractile responses. PKC activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410f5205aa49bb076f0d76a50c5eae3
https://doi.org/10.1042/bj2700375

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Analysis of the PKC-gamma-related immunocrossreactive region of a novel leukocyte protein gamma-rp

Autor: J I, Smallwood, S E, Malawista

Publikováno v: Inflammation. 23(4)

The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa4b978d0bfbb3731197e026bbfd4ea7
https://pubmed.ncbi.nlm.nih.gov/10443800

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TECHNICAL NOTE: measurement of cAMP-dependent protein kinase activity using a fluorescent-labeled kemptide

Autor: L J, MacAla, J P, Hayslett, J I, Smallwood

Publikováno v: Kidney international. 54(5)

Traditional protein kinase assays include the use of [32P] labeled ATP as phosphate donor and a substrate protein or peptide as phosphoreceptor. Since this approach has a number of drawbacks in addition to generating ionizing radiation, several non-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f97727a5b91a8048531539369c1db27e
https://pubmed.ncbi.nlm.nih.gov/9844154

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An apparently novel protein of human leukocytes, reactive with an antibody to protein kinase C-gamma, is rapidly modified upon cell activation: initial characterization in neutrophils and their cytoplasts

Autor: J I, Smallwood, S E, Malawista

Publikováno v: Inflammation. 22(1)

On immunoblots of human neutrophil cytoplasts (U-CYT), a previously undescribed 97 kDa protein was revealed by intense and selective reaction with an antibody that was initially raised to recognize PKC-gamma. Denoted "gamma-rp" for gamma-related prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df740f45fe4860d735b50b6bf1929fc1
https://pubmed.ncbi.nlm.nih.gov/9484647

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An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies

Autor: E, Fikrig, B, Liu, L L, Fu, S, Das, J I, Smallwood, R A, Flavell, D H, Persing, R T, Schoen, S W, Barthold, S E, Malawista

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(12)

Passive immunization with murine or human Abs to outer surface protein A (OspA) can protect mice against Borrelia burgdorferi, but OspA Abs elicited during natural infection in mice or humans are unable to clear the spirochete from the infected host.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::316221c82087fadf006a88de1a7a2a12
https://pubmed.ncbi.nlm.nih.gov/7499856

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Misoprostol stimulates leukocyte cyclic adenosine 3',5' monophosphate production and synergizes with colchicine: novel combination of established drugs may boost anti-inflammatory potential

Autor: J I, Smallwood, S E, Malawista

Publikováno v: The Journal of pharmacology and experimental therapeutics. 269(3)

Elevation of intracellular cyclic adenosine 3',5' monophosphate (cAMP) inhibits various proinflammatory and immune responses of leukocytes. Among agents known to stimulate cAMP production in these cells, prostaglandins E (PGEs) have received particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb4b1e427b5cc1ec965124b0d7a12417
https://pubmed.ncbi.nlm.nih.gov/7516968

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Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets

Autor: R, Calle, S, Ganesan, J I, Smallwood, H, Rasmussen

Publikováno v: The Journal of biological chemistry. 267(26)

In order to further evaluate the role of protein kinase C activation in glucose-induced insulin secretion, the extent of phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) was examined in freshly isolated rat pancreatic isl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c9d2b6aa18cc475cecbe25f67595956
https://pubmed.ncbi.nlm.nih.gov/1527003

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Colchicine, crystals, and neutrophil tyrosine phosphorylation

Autor: J I Smallwood, S E Malawista

Publikováno v: Journal of Clinical Investigation. 92:1602-1603

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca1a3f42ad986c0b5b41c4c5251b26f
https://doi.org/10.1172/jci116742

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Evidence that the erythrocyte calcium pump catalyzes a Ca2+:nH+ exchange

Autor: J I, Smallwood, D M, Waisman, D, Lafreniere, H, Rasmussen

Publikováno v: The Journal of biological chemistry. 258(18)

Treatment of whole erythrocytes with 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS) results in inhibition of ATP and phosphate-dependent Ca2+ transport in subsequently prepared inside-out vesicles (IOV). Accumulation of phosphate into IOV i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c76c93fed7c4b8b743ef463c1750e2ec
https://pubmed.ncbi.nlm.nih.gov/6136513

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