Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J I Smallwood"'
Autor:
E Fikrig, B Liu, L L Fu, S Das, J I Smallwood, R A Flavell, D H Persing, R T Schoen, S W Barthold, S E Malawista
Publikováno v:
The Journal of Immunology. 155:5700-5704
Passive immunization with murine or human Abs to outer surface protein A (OspA) can protect mice against Borrelia burgdorferi, but OspA Abs elicited during natural infection in mice or humans are unable to clear the spirochete from the infected host.
Publikováno v:
Biochemical Journal. 270:375-381
Using intact muscle strips from the bovine carotid artery, the time course of translocation of protein kinase C (PKC) from the cytosol to the membrane fraction was measured in response to various agonists that induce contractile responses. PKC activi
Autor:
J I, Smallwood, S E, Malawista
Publikováno v:
Inflammation. 23(4)
The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for
Publikováno v:
Kidney international. 54(5)
Traditional protein kinase assays include the use of [32P] labeled ATP as phosphate donor and a substrate protein or peptide as phosphoreceptor. Since this approach has a number of drawbacks in addition to generating ionizing radiation, several non-i
Autor:
J I, Smallwood, S E, Malawista
Publikováno v:
Inflammation. 22(1)
On immunoblots of human neutrophil cytoplasts (U-CYT), a previously undescribed 97 kDa protein was revealed by intense and selective reaction with an antibody that was initially raised to recognize PKC-gamma. Denoted "gamma-rp" for gamma-related prot
Autor:
J I, Smallwood, S E, Malawista
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(3)
Elevation of intracellular cyclic adenosine 3',5' monophosphate (cAMP) inhibits various proinflammatory and immune responses of leukocytes. Among agents known to stimulate cAMP production in these cells, prostaglandins E (PGEs) have received particul
Publikováno v:
The Journal of biological chemistry. 267(26)
In order to further evaluate the role of protein kinase C activation in glucose-induced insulin secretion, the extent of phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) was examined in freshly isolated rat pancreatic isl
Autor:
J I Smallwood, S E Malawista
Publikováno v:
Journal of Clinical Investigation. 92:1602-1603
Publikováno v:
The Journal of biological chemistry. 258(18)
Treatment of whole erythrocytes with 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS) results in inhibition of ATP and phosphate-dependent Ca2+ transport in subsequently prepared inside-out vesicles (IOV). Accumulation of phosphate into IOV i
Publikováno v:
The Journal of biological chemistry. 263(5)
Using either inside-out vesicles (IOV) prepared from human erythrocytes or purified Ca2+-ATPase from the same source, the effects of protein kinase C (Ca2+/phospholipid-dependent enzyme) on Ca2+ transport and Ca2+-ATPase activity were measured. Incub