Výsledky vyhledávání

Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer

Autor: Gareth Griffiths, Simon Gollins, Lisette Sheena Nixon, John Staffurth, R Roy, Stephen Falk, J I Geh, Jonathan Rees, Jane M Blazeby, Ruby Ray, N Bashir, Chris Nicholas Hurt, S. Mukherjee, Tom Crosby, David Cunningham, Tim Maughan, John Bridgewater

Publikováno v: Rees, J R E, Hurt, C N, Gollins, S, Mukherjee, S, Maughan, T, Falk, S J, Staffurth, J, Ray, R, Bashir, N, Geh, J I, Cunningham, D, Roy, R, Bridgewater, J, Griffiths, G, Nixon, L S, Blazeby, J M & Crosby, T 2015, ' Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer ', British Journal of Cancer, vol. 113, no. 4, pp. 603-610 . https://doi.org/10.1038/bjc.2015.258
British Journal of Cancer

BACKGROUND:Limited data describe patient-reported outcomes (PROs) of localised oesophageal cancer treated with definitive chemoradiotherapy(CRT). The phase 2/3 SCOPE-1 trial assessed the effectiveness of CRT±cetuximab. The trial for the first time p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bbb0db8eb042f3a9bf948a9bd0c44f
https://doi.org/10.1038/bjc.2015.258

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Tumour- and treatment-related colostomy rates following mitomycin C or cisplatin chemoradiation with or without maintenance chemotherapy in squamous cell carcinoma of the anus in the ACT II trial

Autor: Rubina Begum, Latha Kadalayil, Rob Glynne-Jones, Charles Lowdell, Jonathan A. Ledermann, David Sebag-Montefiore, Helen Meadows, Roger D James, Sandy Beare, J I Geh, Leslie Samuel, David Cunningham

Publikováno v: Annals of Oncology. 25:1616-1622

Background: Squamous cell carcinoma of the anus (SCCA) is highly sensitive to chemoradiation (CRT) which achieves good loco-regional control and preserves anal function. However, some patients require permanent stoma formation either as a result of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9de259b113ef4882861aa96fa3815eb
https://doi.org/10.1093/annonc/mdu188

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Linear Accelerator Stereotactic Radiosurgery for Vestibular Schwannomas: A UK Series

Autor: H. Benghiat, J I Geh, Peter Nightingale, R.M. Irving, Garth Cruickshank, M. Tiffany, Andrew Hartley, G. Heyes, Paul Sanghera, David Spooner

Publikováno v: Clinical Oncology. 26:309-315

Aims To evaluate non-auditory toxicity and local control after linear accelerator stereotactic radiosurgery (SRS) for the treatment of vestibular schwannomas. Materials and methods The institutional policy was to use SRS for radiologically progressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008df49b826949ca09673e478782f364
https://doi.org/10.1016/j.clon.2014.02.008

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Chemoradiotherapy for Rectal Cancer: An Updated Analysis of Factors Affecting Pathological Response

Autor: J I Geh, Christopher C. McConkey, D. W. Y. Wong, Paul Sanghera, Andrew Hartley

Publikováno v: Clinical Oncology. 20:176-183

Aims With the aim of improving locoregional control, the use of preoperative chemoradiotherapy (CRT) for rectal cancer has increased. A pathological complete response (pCR) is often used as a surrogate marker for the efficacy of different CRT schedul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f0760ee72eed804e654d22ececb2a3
https://doi.org/10.1016/j.clon.2007.11.013

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Multicentre study of short-course radiotherapy and transanal endoscopic microsurgery for early rectal cancer

Autor: Simon P. Bach, M Steward, David Sebag-Montefiore, Doug Speake, B Levy, J I Geh, James Hill, C J Smart, Jonathan Robinson, S Korsgen

Publikováno v: The British journal of surgery. 103(8)

Background Organ-preserving treatment for early-stage rectal cancer may avoid the substantial perioperative morbidity and functional sequelae associated with total mesorectal excision (TME). The initial results of an organ-preserving approach using p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd70c69d574b0d33a8f5edb76857bc6
https://pubmed.ncbi.nlm.nih.gov/27146472

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Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II/III trials

Autor: Andrew Hartley, Christopher C. McConkey, K.F. Ho, J I Geh

Publikováno v: The British Journal of Radiology. 78:934-938

Pathological complete response (pCR) has been used as a marker for the efficacy of pre-operative chemoradiotherapy (CRT) schedules in rectal cancer. To date there have been no randomized trials comparing CRT regimens in rectal cancer. Prospective pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8bc7d1bcb1bd33f5bef2804777f722
https://doi.org/10.1259/bjr/86650067

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A phase I/II study of gemcitabine and fractionated cisplatin in an outpatient setting using a 21-day schedule in patients with advanced and metastatic bladder cancer

Autor: Daniel H. Palmer, D. R. Peake, Nicholas D. James, J I Geh, David Spooner, Syed A. Hussain, Deborah D. Stocken, P. Riley

Publikováno v: British Journal of Cancer

A randomised phase III trial of MVAC (methotrexate, vincristine, doxorubicin, cisplatin) vs gemcitabine and cisplatin (GC) (G 1000 mg m(-2) days 1, 8, and 15 plus C 70 mg m(-2) day 2, q 4 wks) indicated GC had similar efficacy and lower toxicity (JCO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741f2ae454c804783afc6bb0752f7518
http://europepmc.org/articles/PMC2409873

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Late Toxicity after Short Course Preoperative Radiotherapy and Total Mesorectal Excision for Resectable Rectal Cancer

Autor: Christopher C. McConkey, S. Giridharan, J I Geh, M. King, Andrew Hartley, S. Tolan

Publikováno v: Clinical Oncology. 15:233-236

Aims: The late toxicity of short-course preoperative radiotherapy (SCPRT) after total mesorectal excision (TME) in resectable rectal cancer has not been adequately documented. The acute toxicity in a series of 176 consecutive patients has been previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee527cb2062e2a750d4f7a4f015ffa2
https://doi.org/10.1016/s0936-6555(03)00118-3

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