Zobrazeno 1 - 10 of 597 pro vyhledávání: '"J I Bell"'
1
Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?
Autor: K D Pile, B P Wordsworth, J I Bell
There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e73e8898e1ac739410409bd9be6a2df
https://doi.org/10.1136/ard.51.11.1250
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2
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease
Autor: J. M. Farrant, Michael Bunce, Derek P. Jewell, C Julier, J I Bell, Kenneth I. Welsh, J Satsangi
BACKGROUND: Despite strong evidence implicating immune dysfunction and genetic predisposition in the pathogenesis of the chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis, the importance of the genes of the major histocompati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533ab1471502ac39b5ddba339158f59d
https://doi.org/10.1016/s0140-6736(96)90734-5
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3
Akademický článek
TIL Therapy in Lung Cancer: Current Progress and Perspectives.
Autor: Hu, Weilei1,2,3 (AUTHOR), Bian, Yifei2,3 (AUTHOR), Ji, Hongbin1,2,3,4 (AUTHOR) hbji@sibcb.ac.cn
Publikováno v: Advanced Science. 12/11/2024, Vol. 11 Issue 46, p1-16. 16p.
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4
Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease
Autor: Se E. Marshall, Michael Bunce, Pj J. Hunt, J I Bell, Ap P. Weetman, Ja A. H. Wass, Ki I. Welsh
Publikováno v: Clinical Endocrinology. 55:491-499
OBJECTIVES Associations between autoimmune thyroid disease and antigens of the major histocompatibility complex (MHC) have long been recognized. Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8571a4179e8c1e307c2a5edaae1321e6
https://doi.org/10.1046/j.1365-2265.2001.01356.x
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5
CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus
Autor: E C Wang, P A Moss, P Frodsham, P J Lehner, J I Bell, L K Borysiewicz
Publikováno v: The Journal of Immunology. 155:5046-5056
CD8+CD57+ lymphocytes from normal peripheral blood are divided into T cells expressing high levels of CD8 and NK cells expressing low levels of surface CD8. Increased numbers of CD8highCD57+ T cells correlate with previous exposure to human cytomegal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bc82ac3f92cdb66a5df63e9cd542d4c
https://doi.org/10.4049/jimmunol.155.10.5046
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6
Polygenic disease
Autor: J I, Bell
Publikováno v: Current Opinion in Genetics & Development. 3:466-469
Considerable success is now being achieved in defining genetic susceptibility loci in polygenic disease. In particular, new susceptibility loci have been identified in hypertension, type I and type II diabetes, asthma and malaria infection. The appro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88da106708bfd4e08e38729e8731722a
https://doi.org/10.1016/0959-437x(93)90121-5
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7
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
Autor: C. Julier, R. N. Hyer, J. Davies, F. Merlin, P. Soularue, L. Briant, G. Cathelineau, I. Deschamps, J. I. Rotter, P. Froguel, C. Boitard, J. I. Bell, G. M. Lathrop
Publikováno v: Nature. 354:155-159
A class of alleles at the VNTR (variable number of tandem repeat) locus in the 5' region of the insulin gene (INS) on chromosome 11p is associated with increased risk of insulin-dependent diabetes mellitus (IDDM), but family studies have failed to de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59aaedee8f6c4b23098fbcbbcc62cb0
https://doi.org/10.1038/354155a0
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8
Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease
Autor: P J, Hunt, S E, Marshall, A P, Weetman, M, Bunce, J I, Bell, J A, Wass, K I, Welsh
Publikováno v: Clinical endocrinology. 55(4)
Associations between autoimmune thyroid disease and antigens of the major histocompatibility complex (MHC) have long been recognized. Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0801-DRB1*03
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4d79e571cf3624d98254959b060c049
https://pubmed.ncbi.nlm.nih.gov/11678832
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9
Reconstitution of antigen presentation in HLA class I-negative cancer cells with peptide-beta2m fusion molecules
Autor: S, Tafuro, U C, Meier, P R, Dunbar, E Y, Jones, G T, Layton, M G, Hunter, J I, Bell, A J, McMichael
Publikováno v: European journal of immunology. 31(2)
Engineered MHC-peptide targets capable of inducing recognition by CTL may prove useful in designing vaccines for infectious disease and cancer. We tested whether peptides directly linked to beta2-microglobulin (beta2m) could complex with human HLA cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2d1bf828602548e3eec3744dd61c643
https://pubmed.ncbi.nlm.nih.gov/11180108
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