Zobrazeno 1 - 2
of 2
pro vyhledávání: '"J I, Germershausen"'
Autor:
P F, Smith, R S, Eydelloth, S J, Grossman, R J, Stubbs, M S, Schwartz, J I, Germershausen, K P, Vyas, P H, Kari, J S, MacDonald
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 257(3)
Recent clinical evidence indicates a potential for skeletal muscle toxicity after therapy with HMG-CoA reductase inhibitors (HMGRIs) in man. Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it m
Autor:
D J, Kornbrust, J S, MacDonald, C P, Peter, D M, Duchai, R J, Stubbs, J I, Germershausen, A W, Alberts
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 248(2)
Lovastatin, a specific inhibitor of the rate-limiting enzyme in cholesterol biosynthesis, HMG-CoA reductase, has been shown to be highly effective in lowering serum cholesterol in animals and humans and thus represents a promising approach to the tre