Výsledky vyhledávání

Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice

Autor: W R Waud, James R. Piper, J. I. Degraw, Cheryl A. Johnson, W. T. Colwell, R L Smith, Frank Sirotnak

Publikováno v: Journal of medicinal chemistry. 40(3)

Twenty-six compounds derived from the 5-deaza- and 5,10-dideazaaminopterin series of aminopterin analogues were evaluated for antiarthritic activity in the mouse type II collagen model. New compounds in the 5-deaza series were prepared by alkylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0adc2fbe98398fbc28817f8eaa7f70
https://pubmed.ncbi.nlm.nih.gov/9022805

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THE PREPARATION OF 5-ALKYLTHIO, BRANCHED TRYPTAMINES

Autor: J. I. DeGraw, J. Kenneth Horner, W. A. Skinner

Publikováno v: Canadian Journal of Chemistry. 44:307-313

The Japp–Klingemann reaction has been employed to prepare six new tryptamines. Data on the intermediate phenylhydrazones, β-carbolines, and tryptamine carboxylic acids are presented. Syntheses of 5-methyl-, 6-methyl-, 5,5-dimethyl-, and 5,6-dimeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a06453b1d43ffaa067a4432f2a8f5e1
https://doi.org/10.1139/v66-042

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Substituted 1,2,3,4-tetrahydro-β-carbolines

Autor: W. A. Skinner, J. I. DeGraw

Publikováno v: Canadian Journal of Chemistry. 45:63-66

A series of 6-substituted 3- or 4-methyl- and 4,4-dimethyl-1,2,3,4-tetrahydro-β-carbolines was prepared by reduction of the appropriate 1,2,3,4-tetrahydro-1-oxo-β-carbolines. Lithium aluminium hydride was employed for all but the 3-methyl compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c2abb8a5b4aa409dd5a09bbfb59c22c
https://doi.org/10.1139/v67-011

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Synthesis of 2-amino-4-hydroxy-1,3,5-triazanaphthalenes

Autor: V. H. Brown, J. I. DeGraw

Publikováno v: Journal of Heterocyclic Chemistry. 13:439-441

The synthesis of 2-amino-4-hydroxy-6-amyl-1,3,5-triazanaphthalene (8) is described as a model sequence pertinent to preparation of 8-deazafolic acid and its analogs. Condensation of 2-acet-amido-4-hydroxy-6-pyrimidinealdehyde (3) with dimethyl 2-oxoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71a07873e9b855d86792717e1b35ec07
https://doi.org/10.1002/jhet.5570130304

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New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice

Autor: F A, Schmid, F M, Sirotnak, G M, Otter, J I, DeGraw

Publikováno v: Cancer treatment reports. 69(5)

In an extension of our prior studies in murine tumor models, we examined two new folate analogs in the 10-deaza-aminopterin series for antitumor activity against a group of human tumor xenografts in nude mice. In all three xenograft models studied, M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d50c94dacf70397f19662f139bda246e
https://pubmed.ncbi.nlm.nih.gov/4005878

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