Zobrazeno 1 - 10
of 294
pro vyhledávání: '"J Hund"'
Autor:
Aaron D. Argall, Holly C. Sucharski-Argall, Luke G. Comisford, Sallie J. Jurs, Jack T. Seminetta, Michael J. Wallace, Casey A. Crawford, Sarah S. Takenaka, Mei Han, Mona El Refaey, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8403 (2024)
Altered ankyrin-R (AnkR; encoded by ANK1) expression is associated with diastolic function, left ventricular remodeling, and heart failure with preserved ejection fraction (HFpEF). First identified in erythrocytes, the role of AnkR in other tissues,
Externí odkaz:
https://doaj.org/article/788ff8b6db97434b9710c167319a61c4
Autor:
Kelsey M. Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A. Baer, Katherine R. Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K. Shettigar, Mark T. Ziolo, Thomas J. Hund, Loren E. Wold, Dmitry Terentyev, Kristin I. Stanford
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101914- (2024)
Objective: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the meta
Externí odkaz:
https://doaj.org/article/43233158c48a4f618c81e1532dc8152a
Autor:
Eun-A Kwak, Christopher C. Pan, Aaron Ramonett, Sanjay Kumar, Paola Cruz-Flores, Tasmia Ahmed, Hannah R. Ortiz, Jeffrey J. Lochhead, Nathan A. Ellis, Ghassan Mouneimne, Teodora G. Georgieva, Yeon Sun Lee, Todd W. Vanderah, Tally Largent-Milnes, Peter J. Mohler, Thomas J. Hund, Paul R. Langlais, Karthikeyan Mythreye, Nam Y. Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Defective angiogenesis remains a high source of morbidity in multiple disorders. Here they show that βIV-spectrin, a membrane-associated cytoskeletal protein, is essential for regulation of endothelial tip cell populations and VEGF signaling during
Externí odkaz:
https://doaj.org/article/9b6fe5a83d2b46eeafef20d5197ddbd4
Autor:
Drew M. Nassal, Rebecca Shaheen, Nehal J. Patel, Jane Yu, Nick Leahy, Dimitra Bibidakis, Narasimham L. Parinandi, Thomas J. Hund
Publikováno v:
Cells, Vol 12, Iss 5, p 748 (2023)
Cardiac fibroblasts (CFs) maintain the fibrous extracellular matrix (ECM) that supports proper cardiac function. Cardiac injury induces a transition in the activity of CFs to promote cardiac fibrosis. CFs play a critical role in sensing local injury
Externí odkaz:
https://doaj.org/article/a29e01bbb1b5463981044fe26df50d80
Autor:
Louisa Mezache, Heather L. Struckman, Amara Greer-Short, Stephen Baine, Sándor Györke, Przemysław B. Radwański, Thomas J. Hund, Rengasayee Veeraraghavan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF patients have elevated levels of inflammatory cytokines known to promote vascular leak, such as vascular endothelial growth factor A (VEGF). Howev
Externí odkaz:
https://doaj.org/article/339058eefeee476198027db5f79e00fe
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Autor:
Michael J. Wallace, Mona El Refaey, Pietro Mesirca, Thomas J. Hund, Matteo E. Mangoni, Peter J. Mohler
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is a
Externí odkaz:
https://doaj.org/article/12565219d0e44d409486f3ab9e98b4b4
Publikováno v:
Video Journal of Sports Medicine, Vol 1 (2021)
Background: Previous literature has found that hip magnetic resonance imaging (MRI) has lower accuracy and reliability in preoperative diagnosis of cartilage and labral pathology compared with knee and shoulder MRI. This is a notable limitation, as M
Externí odkaz:
https://doaj.org/article/22cdf33d7e1c451283ecf61199872911
Autor:
Crystal M. Ripplinger, Alexey V. Glukhov, Matthew W. Kay, Bastiaan J. Boukens, Nipavan Chiamvimonvat, Brian P. Delisle, Larissa Fabritz, Thomas J. Hund, Bjorn C. Knollmann, Na Li, Katherine T. Murray, Steven Poelzing, T. Alexander Quinn, Carol Ann Remme, Stacey L. Rentschler, Robert A. Rose, Nikki G. Posnack
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(6):H1137-H1166
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although recent advances in cell-based models, including human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM), are contributing to our understanding of electr
Autor:
Cheng-Hsin Liu, Ryan Seo, Tammy Szu-Yu Ho, Michael Stankewich, Peter J Mohler, Thomas J Hund, Jeffrey L Noebels, Matthew N Rasband
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS)
Externí odkaz:
https://doaj.org/article/b0a80c607d4b4ee5b9e6ed64b25767e2