Zobrazeno 1 - 10
of 448
pro vyhledávání: '"J Hopkinson"'
Autor:
Sara Y. Chothia, Vicki L. Emms, Liam A. Thomas, Natasha F. A. Bulman, Paul S. Monks, Rebecca L. Cordell, Richard J. Hopkinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Formaldehyde (HCHO) is a human toxin that is both a pollutant and endogenous metabolite. HCHO concentrations in human biological samples are reported in the micromolar range; however, accurate quantification is compromised by a paucity of se
Externí odkaz:
https://doaj.org/article/c719ce4349844dcc96582cd56d731afa
Publikováno v:
Arthroplasty Today, Vol 25, Iss , Pp 101307- (2024)
Background: Lymphedema is rare in arthroplasty patients but has been associated with a higher complication rate. This study sought to determine the outcomes of total joint arthroplasty in patients with lymphedema as compared to a matched control coho
Externí odkaz:
https://doaj.org/article/ced56a426bdb45c3be6a4f4256e80950
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Formaldehyde (HCHO) is a toxic and carcinogenic pollutant and human metabolite that reacts with biomolecules under physiological conditions. Quantifying HCHO is essential for ongoing biological and biomedical research on HCHO; however, its r
Externí odkaz:
https://doaj.org/article/9e85469425874de88fbe5438b2bc2528
Autor:
Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Formaldehyde is a potent toxic electrophile at high concentrations; however its potential regulatory roles remain unknown. Here, the authors report that formaldehyde can react with terminal proline-containing proteins to generate stable 5,5-bicyclic
Externí odkaz:
https://doaj.org/article/2a8406e75d014635a9536287ad9f6a51
Autor:
Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 14-27 (2021)
Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxi
Externí odkaz:
https://doaj.org/article/232fbe08a0724f6ca2a8f27be76d1d05
Publikováno v:
Radiography. 29:746-751
Autor:
Michael P. Murphy, Ashley E. MacConnell, Cameron J. Killen, Daniel R. Schmitt, Karen Wu, William J. Hopkinson, Nicholas M. Brown
Publikováno v:
The Journal of Arthroplasty. 38:1131-1140
Autor:
Inga Pfeffer, Lennart Brewitz, Tobias Krojer, Sacha A. Jensen, Grazyna T. Kochan, Nadia J. Kershaw, Kirsty S. Hewitson, Luke A. McNeill, Holger Kramer, Martin Münzel, Richard J. Hopkinson, Udo Oppermann, Penny A. Handford, Michael A. McDonough, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
AspH catalyses hydroxylation of asparagine and aspartate residues in epidermal growth factor-like domains (EGFDs). Here, the authors present crystal structures of AspH with and without substrates and show that AspH uses EFGD substrates with a non-can
Externí odkaz:
https://doaj.org/article/f7e2f575ff5740a38a278f59a178aaca
Autor:
N. Courtier, S. Gaze, J. Armes, A. Smith, L. Radley, J. Armytage, M. Simmonds, A. Johnson, T. Gambling, J. Hopkinson
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-9 (2018)
Abstract Background Fatigue is rated as the most distressing side effect of radiotherapy treatment for curable breast cancer. About four in ten women treated experience fatigue, which can last for years after treatment. The impact of this debilitatin
Externí odkaz:
https://doaj.org/article/a140614b5a374ea78d21c54e765728bf
Autor:
Sarah E. Wilkins, Md. Saiful Islam, Joan M. Gannon, Suzana Markolovic, Richard J. Hopkinson, Wei Ge, Christopher J. Schofield, Rasheduzzaman Chowdhury
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Jumonji-C domain containing protein 5 (JMJD5) is essential for animal development but its catalytic activity has remained elusive so far. Here the authors show that human JMJD5 is an arginyl-hydroxylase and present the cofactor, substrate and product
Externí odkaz:
https://doaj.org/article/21f08a0de33a4534a7d964a1710edd68