Zobrazeno 1 - 10
of 147
pro vyhledávání: '"J Henze"'
Autor:
Christian Jede, Laura J. Henze, Kirstin Meiners, Malte Bogdahn, Marcel Wedel, Valeria van Axel
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1069 (2023)
A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption i
Externí odkaz:
https://doaj.org/article/4138e665bcd04d85811abb763486677f
Autor:
Laura J. Henze, Niklas J. Koehl, Joseph P. O'Shea, René Holm, Maria Vertzoni, Brendan T. Griffin
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
A preclinical porcine model that reliably predicts human food effect of fenofibrate was developed. Fenofibrate was administered to pigs as model compound with a positive food effect. Two different types of fed conditions were explored: a FDA style br
Externí odkaz:
https://doaj.org/article/b0e53c7d835c4cd195b7ef88274c3811
Publikováno v:
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bb6f768006884af046e111c412b6d4
https://doi.org/10.1055/s-0043-1762972
https://doi.org/10.1055/s-0043-1762972
Autor:
M. N. Thomas, R. R. Datta, R. Wahba, D. Buchner, C. Chiapponi, C. Kurschat, F. Grundmann, A. Urbanski, S. Tolksdorf, R. Müller, J. Henze, V.-M. Petrescu-Jipa, F. Meyer, C. J. Bruns, D. L. Stippel
Publikováno v:
Langenbeck's Archives of Surgery. 408
Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder and accounts for 5–10% of all cases of kidney failure. 50% of ADPKD patients reach kidney failure by the age of 58 years requiring dialysis or transplantat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a968c8d9d722e202ee7647218c0818
https://doi.org/10.1007/s00423-022-02737-9
https://doi.org/10.1007/s00423-022-02737-9
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 564 (2020)
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidate
Externí odkaz:
https://doaj.org/article/e8396e284ac84c49a16691b9fa38b952
Autor:
M N, Thomas, R R, Datta, R, Wahba, D, Buchner, C, Chiapponi, C, Kurschat, F, Grundmann, A, Urbanski, S, Tolksdorf, R, Müller, J, Henze, V-M, Petrescu-Jipa, F, Meyer, C J, Bruns, D L, Stippel
Publikováno v:
Langenbeck's archives of surgeryReferences. 408(1)
Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder and accounts for 5-10% of all cases of kidney failure. 50% of ADPKD patients reach kidney failure by the age of 58 years requiring dialysis or transplantation. Nephr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5c53f5eb137181d7188f9d0d68cb56c
https://pubmed.ncbi.nlm.nih.gov/36602631
https://pubmed.ncbi.nlm.nih.gov/36602631
Akademický článek
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Autor:
Laura J. Henze, Christos Reppas, Jennifer B. Dressman, Marina Statelova, Chara Litou, Christina Pentafragka, Patrick J O'Dwyer, Karl J. Box, Brendan T. Griffin, Maria Vertzoni
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:437-446
ObjectivesTo summarise key contributions of the Pharmaceutical Education and Research with Regulatory Links (PEARRL) project (2016–2020) to the optimisation of existing and the development of new biopharmaceutics tools for evaluating the in vivo pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2786ebf080a4e3efc047c84cefde61
https://doi.org/10.1093/jpp/rgaa055
https://doi.org/10.1093/jpp/rgaa055
Autor:
Andreas Marx, Niklas J. Koehl, René Holm, Brendan T. Griffin, John J. Keating, Thomas De Vijlder, Martin Kuentz, Laura J. Henze
Publikováno v:
Koehl, N J, Henze, L J, Holm, R, Kuentz, M, Keating, J J, De Vijlder, T, Marx, A & Griffin, B T 2022, ' Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax ', Journal of Pharmaceutical Sciences, vol. 111, no. 1, pp. 164-174 . https://doi.org/10.1016/j.xphs.2021.09.008
Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f5094421f520bc605cb9eabbe0467
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
Autor:
Niklas J. Koehl, René Holm, Laura J. Henze, Maria Vertzoni, Joseph P. O'Shea, Brendan T. Griffin
The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine and human intestinal fluids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226fa1ba7d8ec9c4774bb9f66c4003db
https://hdl.handle.net/10468/11444
https://hdl.handle.net/10468/11444