Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J H Verheijen"'
Autor:
R, Hanemaaijer, C F, Sier, H, Visser, L, Scholte, N, van Lent, K, Toet, K, Hoekman, J H, Verheijen
Publikováno v:
Annals of the New York Academy of Sciences. 878:141-149
Matrix metalloproteinases (MMPs) play an important role in many pathologic processes, but their activities are difficult to determine since no simple specific and/or chromogenic substrate exists. We have developed a novel MMP activity assay using a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e190b902c1e454aec5fd00fd40b29135
https://doi.org/10.1111/j.1749-6632.1999.tb07680.x
https://doi.org/10.1111/j.1749-6632.1999.tb07680.x
Autor:
W H, van der Laan, H K, Ronday, J M, TeKoppele, F C, Breedveld, T W, Huizinga, J H, Verheijen
Publikováno v:
Clinical and experimental rheumatology. 21(3)
In the present study, the effects of plasmin antagonist tranexamic acid (TEA) on urinary pyridinoline excretion rates were investigated in rheumatoid arthritis (RA) patients.The study was set up as a double-blind placebo-controlled pilot study. Ten p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7caacb3078fcc390646c2f7480b325a9
https://pubmed.ncbi.nlm.nih.gov/12846058
https://pubmed.ncbi.nlm.nih.gov/12846058
Autor:
W H van der Laan, P H A Quax, C A Seemayer, L G M Huisman, E J Pieterman, J M Grimbergen, J H Verheijen, F C Breedveld, R E Gay, S Gay, T W J Huizinga, T Pap
Publikováno v:
Gene Therapy, 3, 10, 234-242
Matrix metalloproteinases (MMPs) are believed to be pivotal enzymes in the invasion of articular cartilage by synovial tissue in rheumatoid arthritis (RA). Here, we investigated the effects of gene transfer of tissue inhibitors of metalloproteinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1746868a7ffe9d77b48917adc1ecb02
https://pubmed.ncbi.nlm.nih.gov/12571631
https://pubmed.ncbi.nlm.nih.gov/12571631
Publikováno v:
Thrombosis and haemostasis. 88(2)
Although many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated fibrinogen has an etiological role in the pathogenesis or is only a reflection of the ongoing dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::859110bef85f0922f5b313c5df1e0732
https://pubmed.ncbi.nlm.nih.gov/12195708
https://pubmed.ncbi.nlm.nih.gov/12195708
Publikováno v:
Clinicalexperimental metastasis. 18(6)
Recent reports suggest that elevated levels of plasminogen activator inhibitor-1 (PAI-1) may contribute to tumour progression. The studies reported here were designed to help elucidate PAI-1's contribution to the invasive and migratory phenotype. Ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::facb141f4cce8d594a940a16404f67db
https://pubmed.ncbi.nlm.nih.gov/11592301
https://pubmed.ncbi.nlm.nih.gov/11592301
Publikováno v:
Thrombosis and haemostasis. 86(2)
Hyperfibrinogenemia is a risk predictor in several diseases, including cardiovascular disease. Nevertheless, it remains unknown whether elevated fibrinogen has an etiologic role in or is a reflection of disease pathogenesis, or both. To examine this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0febf75960132f6a6be878b5a0802a1
https://pubmed.ncbi.nlm.nih.gov/11521995
https://pubmed.ncbi.nlm.nih.gov/11521995
Publikováno v:
Diabetic medicine : a journal of the British Diabetic Association. 18(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7164f452752f25c53ca1c902ca96630
https://pubmed.ncbi.nlm.nih.gov/11472458
https://pubmed.ncbi.nlm.nih.gov/11472458
Publikováno v:
Thrombosis and haemostasis. 85(6)
The fibrinogen Aalpha, Bbeta, and gamma polypeptides are encoded by three separate genes, which are arranged in the order gamma-alpha-beta. In order to study the biosynthesis of fibrinogen in vivo we generated a line of transgenic mice carrying extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::715549af8255c37603af3a16e16a0397
https://pubmed.ncbi.nlm.nih.gov/11434679
https://pubmed.ncbi.nlm.nih.gov/11434679
Autor:
T, Pap, W H, van der Laan, K R, Aupperle, R E, Gay, J H, Verheijen, G S, Firestein, S, Gay, M, Neidhart
Publikováno v:
Arthritis and rheumatism. 43(11)
To determine the role of chondrocytes and factors released from chondrocytes in cartilage destruction by fibroblast-like synoviocytes (FLS) derived from patients with rheumatoid arthritis (RA).RA FLS from 2 patients were implanted into SCID mice, tog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26f85becb5644d42aa75772f2ddef0bb
https://pubmed.ncbi.nlm.nih.gov/11083277
https://pubmed.ncbi.nlm.nih.gov/11083277
Autor:
W H, van der Laan, T, Pap, H K, Ronday, J M, Grimbergen, L G, Huisman, J M, TeKoppele, F C, Breedveld, R E, Gay, S, Gay, T W, Huizinga, J H, Verheijen, P H, Quax
Publikováno v:
Arthritis and rheumatism. 43(8)
Joint destruction in rheumatoid arthritis (RA) is a result of degradation and invasion of the articular cartilage by the pannus tissue. The present study was undertaken to examine the role of the plasminogen activation system in cartilage degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::314b1f0c195677ea6ca1603f9d9098c4
https://pubmed.ncbi.nlm.nih.gov/10943860
https://pubmed.ncbi.nlm.nih.gov/10943860