Zobrazeno 1 - 10 of 10 pro vyhledávání: '"J H Schumacher"'
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Elevated production of interferon-γ and interleukin 4 by mature T cells from autoimmune Ipr mice correlates with Pgp-1 (CD44) expression
Autor: Genine Winslow, J H Schumacher, Tim R. Mosmann, Ralph C. Budd
Publikováno v: European Journal of Immunology. 21:1081-1084
The cell surface glycoprotein, Pgp-1 (CD44), has been shown to be a marker of murine memory T lymphocytes. When activated, Pgp-1hi memory T cells produce strikingly higher amounts of interferon-gamma (IFN-gamma) than naive Pgp-1lo T cells, yet both s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4ef0b20a09e5df1c842c21bc2179b7
https://doi.org/10.1002/eji.1830210435
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3
Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10
Autor: Anne O'Garra, Alan C. Whitmore, Paulo Vieira, Tim R. Mosmann, Alan M. Stall, J H Schumacher, Hope S. Rugo, Larry W. Arnold, Jim Cupp, Vineeta Dhar, Maureen Howard, Geoffrey Haughton, Dina Barbis, Kevin W. Moore, Genevieve Stapleton, Michael Pearce
Publikováno v: International Immunology. 2:821-832
We have examined a panel of murine Ly-l+ B lymphomas and purified normal murine peritoneal B cells separated into subsets on the basis of expression of the Ly-1 surface antigen, for their ability to produce cytokines. Where possible, we have used a c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8da7570b492ecc173873433b255232
https://doi.org/10.1093/intimm/2.9.821
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5
Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay
Autor: T R, Mosmann, J H, Schumacher, D F, Fiorentino, J, Leverah, K W, Moore, M W, Bond
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 145(9)
Hybridomas were produced from a rat that was immunized with partially purified proteins from supernatants of induced Th2 cells. These preparations were enriched for cytokine synthesis inhibitory factor (CSIF, IL-10). The mAb in the supernatants were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b05c97c3f040a420185cae8747185799
https://pubmed.ncbi.nlm.nih.gov/2145365
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6
Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells
Autor: N E, Street, J H, Schumacher, T A, Fong, H, Bass, D F, Fiorentino, J A, Leverah, T R, Mosmann
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 144(5)
Many long term mouse Th clones express either the type 1 or type 2 Th cell (Th1 or Th2) cytokine secretion phenotype. In this report we present two lines of evidence for the existence of additional Th differentiation states. Lectin-stimulated spleen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4f9ccc850ccfe2825df7a0956d82b2f
https://pubmed.ncbi.nlm.nih.gov/1968485
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7
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
Autor: J H Schumacher, Tim R. Mosmann, Holly M. Cherwinski, K D Brown
Publikováno v: The Journal of Experimental Medicine
Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using mRNA hybridization methods to examine 11 different mRNAs induced by Con A. The two types of CD4+ Th cell clone described previously were clearly distinguished by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb4d75edc84cf786416820a3c2dd38b
http://europepmc.org/articles/PMC2189643
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8
Akademický článek
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9
Heterogeneity of Mouse Helper T Cells and Cross-Regulation of TH1 and TH2 Clones
Autor: Nancy E. Street, Mary L. Trounstine, J H Schumacher, Kevin W. Moore, Martha W. Bond, David Fiorentino, Tim R. Mosmann, T. A. T. Fong, J. A. Leverah, Pedro L. Vieira
Publikováno v: Progress in Immunology ISBN: 9783642837579
The immune response against most antigens or infections shows a characteristic pattern of effector functions, typical of that antigen. For many pathogens, the immune response is appropriate, i.e. the effector functions are capable of neutralising or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d876c36a86b1961180203f3640242802
https://doi.org/10.1007/978-3-642-83755-5_82
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10
The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent
Autor: J H, Schumacher, A, O'Garra, B, Shrader, A, van Kimmenade, M W, Bond, T R, Mosmann, R L, Coffman
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 141(5)
Four rat mAb directed against mouse IL-5 have been characterized by their ability to remove and neutralize mouse IL-5 activity in various bioassays. All four mAb absorbed IL-5 activity from solution. Although all were able to neutralize mouse IL-5 bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa3a88f6df0bfd446e6455b00627cefa
https://pubmed.ncbi.nlm.nih.gov/2970507
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