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Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor

Autor: C C Solorzano, R Ksontini, J H Pruitt, P J Hess, P D Edwards, A Kaibara, A Abouhamze, T Auffenberg, R E Galardy, J N Vauthey, E M Copeland, C K Edwards, G Y Lauwers, M Clare-Salzler, S L MacKay, L L Moldawer, D D Lazarus

Publikováno v: The Journal of Immunology. 158:414-419

TNF-alpha is a pleiotropic cytokine that exists both as a 26-kDa cell-associated and a 17-kDa soluble form. Recently, a class of matrix metalloproteinase inhibitors has been identified that can prevent the processing by TNF convertase of 26-kDa TNF-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbbc678427a25e7f740e538ac6396479
https://doi.org/10.4049/jimmunol.158.1.414

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Visceral ischemia-reperfusion injury promotes tumor necrosis factor (TNF) and interleukin-1 (IL-1) dependent organ injury in the mouse

Autor: M B, Welborn, W G, Douglas, Z, Abouhamze, T, Auffenburg, A S, Abouhamze, J, Baumhofer, J M, Seeger, J H, Pruitt, P D, Edwards, R, Chizzonite, D, Martin, L L, Moldawer, T R, Harward

Publikováno v: Shock (Augusta, Ga.). 6(3)

Acute visceral ischemia and subsequent reperfusion injury, which accompanies the surgical repair of a thoracoabdominal aorta aneurysm, is associated with high rates of morbidity and mortality. The purpose of the present study was to determine whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f82e397369295c52b05adab802934ba
https://pubmed.ncbi.nlm.nih.gov/8885081

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Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome

Autor: J H, Pruitt, M B, Welborn, P D, Edwards, T R, Harward, J W, Seeger, T D, Martin, C, Smith, J A, Kenney, R I, Wesdorp, S, Meijer, M A, Cuesta, A, Abouhanze, E M, Copeland, J, Giri, J E, Sims, L L, Moldawer, H S, Oldenburg

Publikováno v: Blood. 87(8)

Plasma interleukin-1 (IL-1) activity is modulated in part through the simultaneous appearance of several inhibitors of IL-1 action, including interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II receptor (IL-1RII). However, little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::900dbf3701b2c74ba26ce6738f7b7914
https://pubmed.ncbi.nlm.nih.gov/8605344

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