Výsledky vyhledávání

Autor: C. A. Lee, C. M. Kessler, D. Varon, U. Martinowitz, M. Heim, J. H. CONDRA

Publikováno v: Haemophilia. 4:610-615

Resistance to the HIV-1 protease inhibitor indinavir involves the accumulation of multiple amino acid substitutions in the viral protease. A minimum of 11 amino acid positions have been identified as potential contributors to phenotypic resistance. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a397bd28de1182c48c7f78ed959bead
https://doi.org/10.1046/j.1365-2516.1998.440610.x

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Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein

Autor: M. J. Berry, J. H. Condra, Robert M. Krug, Barbara A. Broni, Ilkka Julkunen, M. E. Davies

Publikováno v: Journal of Virology. 64:6335-6340

The interferon-induced murine Mx1 protein, which is localized in the nucleus, most likely specifically blocks influenza virus replication by inhibiting nuclear viral mRNA synthesis, including the mRNA synthesis catalyzed by inoculum (parental) virion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2a41dfc60d18d53028b022607d981
https://doi.org/10.1128/jvi.64.12.6335-6340.1990

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Genotypic analysis methods for detection of drug resistance mutations in the HIV-1 proteinase and reverse transcriptase genes

Autor: J G, Sheldon, J H, Condra

Publikováno v: Antiviral therapy. 4(3)

Understanding the basis of human immunodeficiency virus (HIV) drug resistance represents a key requirement for individualized HIV patient care. The genotypic data generated to date have already provided significant insight. However, it is clear that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e36e6453dd48cd86b8f7bbb14cc2f672
https://pubmed.ncbi.nlm.nih.gov/12731752

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In vivo selection of HIV-1 variants with reduced susceptibility to the protease inhibitor L-735,524 and related compounds

Autor: E A, Emini, W A, Schleif, P, Deutsch, J H, Condra

Publikováno v: Advances in experimental medicine and biology. 394

L-735,524 is a potent inhibitor of the HIV-1 protease. In cell culture, the compound interferes with virus replication by causing production of noninfectious immature viral particles containing an unprocessed gag-pol polyprotein. Initial human clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a4a8cd4ecda5b71f034e5b133eae37d
https://pubmed.ncbi.nlm.nih.gov/8815697

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The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors

Autor: E A, Emini, V W, Byrnes, J H, Condra, W A, Schleif, V V, Sardana

Publikováno v: Archives of virology. Supplementum. 9

The nonnucleoside reverse transcriptase (RT) inhibitors are structurally diverse compounds that are specific inhibitors of the human immunodeficiency virus type 1 RT enzyme. The compounds are largely functionally identical and bind to a common site i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9fefba561dca10e8c73a221d053f80be
https://pubmed.ncbi.nlm.nih.gov/7518271

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Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors

Autor: V V, Sardana, E A, Emini, L, Gotlib, D J, Graham, D W, Lineberger, W J, Long, A J, Schlabach, J A, Wolfgang, J H, Condra

Publikováno v: The Journal of biological chemistry. 267(25)

Several novel, structurally distinct classes of specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) nonnucleoside inhibitors have been described recently. These include the pyridinone derivatives L-697,639, L-697,661, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32ddb5a8828b45843d2d29bd4d310dbb
https://pubmed.ncbi.nlm.nih.gov/1381350

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Bacterial expression of antibody fragments that block human rhinovirus infection of cultured cells

Autor: J H, Condra, V V, Sardana, J E, Tomassini, A J, Schlabach, M E, Davies, D W, Lineberger, D J, Graham, L, Gotlib, R J, Colonno

Publikováno v: The Journal of biological chemistry. 265(4)

Human rhinoviruses are the major causative agents of the common cold in humans and have been divided into major and minor groups based on receptor specificity. cDNAs encoding the light and heavy chains of a murine monoclonal antibody that recognizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac9e4e589c400176207116cdffa4822e
https://pubmed.ncbi.nlm.nih.gov/2153680

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Replicative RNA synthesis and nucleocapsid assembly in vesicular stomatitis virus-infected permeable cells

Autor: J H Condra, R A Lazzarini

Publikováno v: Journal of Virology. 36:796-804

A permeable-cell system has been developed to study the replication of vesicular stomatitis virus. When vesicular stomatitis virus-infected BHK cells were permeabilized by lysolecithin treatment, they incorporated nucleoside triphosphates into RNA an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f9964bf63a0bb2b4c9b82d772e2eb0
https://doi.org/10.1128/jvi.36.3.796-804.1980

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