Zobrazeno 1 - 9 of 9 pro vyhledávání: '"J H, van Delft"'
1
Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1
Autor: J H, van Delft, M S, Steenwinkel, J G, van Asten, N, de Vogel, T C, Bruijntjes-Rozier, T, Schouten, P, Cramers, L, Maas, M H, van Herwijnen, F, van Schooten, P M, Hopmans
Publikováno v: The Annals of occupational hygiene. 45(5)
Occupational exposure to polycyclic aromatic hydrocarbons (PAH) increases the risk of developing lung cancer. Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39e80b1087c1259b841478ff1a282125
https://pubmed.ncbi.nlm.nih.gov/11418090
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2
DNA adducts, mutant frequencies, and mutation spectra in various organs of lambda lacZ mice exposed to ethylating agents
Autor: E J, Mientjes, A, Luiten-Schuite, E, van der Wolf, Y, Borsboom, A, Bergmans, F, Berends, P H, Lohman, R A, Baan, J H, van Delft
Publikováno v: Environmental and molecular mutagenesis. 31(1)
To investigate tissue-specific relations between DNA adducts and mutagenesis in vivo, lambda lacZ transgenic mice were treated i.p. with N-ethyl-N-nitrosourea (ENU), diethylnitrosamine (DEN), and ethyl methanesulphonate (EMS). In liver, bone marrow,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0c185c5ebc3b55778f360070ef6a41e
https://pubmed.ncbi.nlm.nih.gov/9464312
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3
Accurate and sensitive quantitation of N7-methyldeoxyguanosine-3'-monophosphate by 32P-postlabeling and storage-phosphor imaging
Autor: J H Van Delft, Kemal Haque, Andrew C. Povey, Siow Ming Lee, Donald P. Cooper
Publikováno v: Chemical research in toxicology. 10(6)
As N7-methyldeoxyguanosine-3'-monophosphate (N7-MedGp) is the major, persistent DNA lesion generated by methylating agents, a combined HPLC/32P-postlabeling assay has been developed to quantitate this adduct in human DNA. N7-MedGp was purified from n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f15b65d67cfe38103821b2af4d124de
https://pubmed.ncbi.nlm.nih.gov/9208172
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4
Determination of N7- and O6-methylguanine in rat liver DNA after oral exposure to hydrazine by use of immunochemical and electrochemical detection methods
Autor: J H, van Delft, M J, Steenwinkel, A J, de Groot, A A, van Zeeland, G, Eberle-Adamkiewicz, M F, Rajewsky, J, Thomale, R A, Baan
Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 35(1)
Hydrazine belongs to a group of compounds for which there is evidence that the in vivo genotoxic effects become manifest only upon exposure to toxic dose levels. The present study was performed to investigate whether this phenomenon is also reflected
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b42c879dd78cd3950826a1be7ceb7a2f
https://pubmed.ncbi.nlm.nih.gov/9024680
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5
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea
Autor: P A, Philip, V L, Souliotis, A L, Harris, A, Salisbury, A D, Tates, K, Mitchell, J H, van Delft, T S, Ganesan, S A, Kyrtopoulos
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(2)
Dacarbazine (DTIC) is a DNA-methylating drug used in the treatment of malignant melanoma. Among the DNA dducts induced by DTIC are N7-methylguanine (N7-meG) and O6-methylguanine (O6-meG). The latter adduct, in particular, may be important in the muta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5f14e8ca475db5103c05d0b4f258978
https://pubmed.ncbi.nlm.nih.gov/9816173
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6
Improvements in the 32P-postlabelling procedure to quantify bulky aromatic DNA adducts
Autor: M J, Steenwinkel, R, Roggeband, J H, van Delft, R A, Baan
Publikováno v: IARC scientific publications. (124)
This contribution describes methodological modifications and improvements that may contribute to inter-assay reproducibility and more accurate adduct quantification for 32P-postlabelling. Firstly, an anion-exchange chromatography procedure was develo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f26f92ad03be536c1aff23d60e131d43
https://pubmed.ncbi.nlm.nih.gov/7693587
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7
Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine
Autor: J H, van Delft, A M, van den Ende, H J, Keizer, J, Ouwerkerk, R A, Baan
Publikováno v: Carcinogenesis. 13(7)
An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine onl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66bd7f79c3f499e0d07046dc58527025
https://pubmed.ncbi.nlm.nih.gov/1638694
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