Výsledky vyhledávání - "J H, Steinbach"

The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors

Autor: P, Li, J R, Bracamontes, B D, Manion, S, Mennerick, J H, Steinbach, A S, Evers, G, Akk

Publikováno v: British journal of pharmacology. 171(23)

Neurosteroids potentiate responses of the GABAA receptor to the endogenous agonist GABA. Here, we examined the ability of neurosteroids to potentiate responses to the allosteric activators etomidate, pentobarbital and propofol.Electrophysiological as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1c446857aa147810cf074a327a79e85
https://pubmed.ncbi.nlm.nih.gov/25117207

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Modulation of GABAA receptor channel gating by pentobarbital

Autor: J. H. Steinbach, G. Akk

Publikováno v: The Journal of Physiology. 537:715-733

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8842e82da32cdd64b05c9cff511f1130
https://doi.org/10.1113/jphysiol.2001.012818

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Selection of stably transfected cells expressing a high level of fetal muscle nicotinic receptors

Autor: J. H. Steinbach, Q. Chen, G. H. Fletcher

Publikováno v: Journal of Neuroscience Research. 40:606-612

We had earlier found that the numbers of mouse muscle nicotinic receptors expressed on the surface of individual cells of a stably transfected clonal line of quail fibroblasts varied from cell to cell (Kopta and Steinbach: J Neurosci 14:3922–3933,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5310148968f576e6944d73d349b9c8
https://doi.org/10.1002/jnr.490400505

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Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions

Autor: M, Chisari, H-J, Shu, A, Taylor, J H, Steinbach, C F, Zorumski, Steven, Mennerick

Publikováno v: British journal of pharmacology. 160(1)

Some neurosteroids, notably 3alpha-hydroxysteroids, positively modulate GABA(A) receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulate GABA receptors. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3098987cff5c441117764586f9cfc24
https://pubmed.ncbi.nlm.nih.gov/20412070

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Active absorption of conjugated bile acids in vivo

Autor: Claudio D. Schteingart, Huong-Tu Ton-Nu, J. H. Steinbach, A. F. Hofmann, A. Schmassmann, S. N. Marcus, Jan Lillienau, M. L. Marquez, Yun Xia, M. A. Angellotti

Publikováno v: Gastroenterology. 100:212-221

Active transport of conjugated bile acids by the distal ileum is required for efficient enterohepatic cycling of bile acids. Experiments were performed in the rat to obtain accurate values for Tmax and Michaelis constant (Km) of the absorptive area o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::477af73ac48063dbd8b5ae3f04debf22
https://doi.org/10.1016/0016-5085(91)90603-i

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Actions of anesthetics on excitatory transmitter-gated channels

Autor: G, Akk, S, Mennerick, J H, Steinbach

Publikováno v: Handbook of experimental pharmacology. (182)

Excitatory transmitter-gated receptors are found in three gene families: the glutamate ionotropic receptors, the Cys-loop receptor family (nicotinic and 5HT3), and the purinergic (P2X) receptors. Anesthetic drugs act on many members of these families

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::770a3d4910e5cd80280dd08b45b2ecc2
https://pubmed.ncbi.nlm.nih.gov/18175086

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Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate

Autor: P, Li, D E, Reichert, A D, Rodríguez, B D, Manion, A S, Evers, V A, Eterović, J H, Steinbach, G, Akk

Publikováno v: British journal of pharmacology. 153(3)

Eupalmerin acetate (EPA) is a marine diterpene compound isolated from the gorgonian octocorals Eunicea succinea and Eunicea mammosa. The compound has been previously shown to modulate muscle-type and neuronal nicotinic acetylcholine receptors, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2bf05325f1d98f6949bf6769b39ea90
https://pubmed.ncbi.nlm.nih.gov/18037909

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ACTIVATION of the GABA-A RECEPTOR MODULATES NEUROSTEROID PHOTOLABELING of VDAC in BRAIN

Autor: N P Akentieva, J Bracamontes, D F Covey, J H Steinbach, A S Evers, St Louis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c72ecfa454e8fa5763ff1a46a94f1336

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Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium

Autor: G. Akk, J. H. Steinbach

Publikováno v: The Journal of physiology. 551(Pt 1)

We have studied the activation and inhibition of the mouse muscle adult-type nicotinic acetylcholine receptor by tetraethylammonium (TEA) and related quaternary ammonium derivatives. The data show that TEA is a weak agonist of the nicotinic receptor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fd6a26e62b7d198c6663713b102dc9
https://pubmed.ncbi.nlm.nih.gov/12824448

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Modulation of GABA(A) receptor channel gating by pentobarbital

Autor: J H, Steinbach, G, Akk

Publikováno v: The Journal of physiology. 537(Pt 3)

1. We have studied the kinetic properties of channel gating of recombinant alpha 1 beta 2 gamma 2L GABA(A) receptors transiently expressed in human embryonic kidney 293 cells, using the cell-attached, single-channel patch-clamp technique. The recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96c00fe2d4292f3ece591fa41e0af1a4
https://pubmed.ncbi.nlm.nih.gov/11744750

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