Zobrazeno 1 - 10
of 86
pro vyhledávání: '"J H, Southard"'
Publikováno v:
Transplant International. 11:S417-S420
Publikováno v:
Langenbeck's Archives of Surgery. 382:343-348
Die Lagerung von Transplantationslebern in kaltem Medium fuhrt zur Aktivierung der Glykolyse aufgrund des Sauerstoffmangels. Die glykolytische Energie ist moglicherweise entscheidend fur das Uberleben der Zelle, und Leberzellen sterben moglicherweise
Publikováno v:
Transplantation Proceedings. 37:335-337
This study was conducted to investigate the effect of starch in the preservation solution during hypothermic machine perfusion (HMP) on endothelial cell and hepatocyte functions in an isolated perfused rat liver model. Livers isolated from male Sprag
Autor:
J A, Van der Hoeven, S, Lindell, R, van Schilfgaarde, G, Molema, G J, Ter Horst, J H, Southard, R J, Ploeg
Publikováno v:
Transplantation. 72(10)
Eighty percent of donor organs come from donors who have suffered brain trauma (brain-dead donors). This unphysiological state alters the hemodynamic and hormonal status of the organ donor. This can cause organ injury, which has been suggested to alt
Publikováno v:
Gut. 49(4)
Organ transplantation has become routine in many centres throughout the world. Although success rates for intestinal transplantation are generally lower than for other organs, it is still high enough to warrant this form of therapy for patients with
Autor:
J S, Kim, J H, Southard
Publikováno v:
Transplantation. 68(7)
Calcium plays an important role in liver preservation and preservation induces depletion of cellular Ca. This may affect hepatocyte cytoskeleton integrity necessary for maintaining cell shape and organ viability. We tested the effects of a microtubul
Publikováno v:
Transplantation. 67(11)
A complication in liver transplantation is increased clotting times due to inhibition of protein synthesis resulting from prolonged hypothermic preservation. Protein synthesis is also blocked in cold preserved hepatocytes. In this study, the mechanis
Alteration in cellular calcium and mitochondrial functions in the rat liver during cold preservation
Autor:
J S, Kim, J H, Southard
Publikováno v:
Transplantation. 65(3)
Preservation injury is multifactorial and its mechanism is still incompletely defined. Calcium may play an important role in preservation injury.The effects of hypothermia on cytosolic free calcium concentration ([Ca2+]I) and total cellular calcium c
Publikováno v:
Langenbecks Archiv fur Chirurgie. 382(6)
Simple cold storage of livers for transplantation activates glycolysis due to lack of oxygen. Energy derived from glycolysis may be critical for cell survival and liver cell death may occur once glycolysis is inhibited in the liver due to accumulatio
Publikováno v:
Hiroshima journal of medical sciences. 45(3)
Livers from fasted animals are believed to be more vulnerable to ischemic injury than those from fed donors. However, we have recently shown the opposite: livers from fasted rats were more tolerant to ischemic injury. Indeed, the survival rate of 60