Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor

Autor: A. J. M. Eerenberg, H. Ten Cate, M C Minnema, W. A. Wuillemin, Dorina Roem, Joost C. M. Meijers, C. E. Hack, J. H. Nuijens

Publikováno v: Blood, 85(6), 1517-1526. American Society of Hematology

From experiments with purified proteins, it has been concluded that factor XIa (FXIa) is inhibited in plasma mainly by alpha 1-antitrypsin (a1AT), followed by antithrombin III (ATIII), C1-inhibitor (C1Inh), and alpha 2-antiplasmin (a2AP). However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6784ca7b0d04408acdbdbbc9fc5f238
https://doi.org/10.1182/blood.v85.6.1517.bloodjournal8561517

Quantification of Functional and Inactivated α2-Macroglobulin in Sepsis

Autor: J. J. Abbink, Strack van Schijndel Rj, A. J. M. Eerenberg, C. E. Hack, J. H. Nuijens, Lambertus G. Thijs, C. C. M. Huijbregts

Publikováno v: Thrombosis and Haemostasis. 65:032-039

Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95589fae9d85c5009612b442beaca53a
https://doi.org/10.1055/s-0038-1647450

Functionalization of Alginate Hydrogels with a Multifunctional Peptide Supports Mesenchymal Stem Cell Adhesion and Reduces Bacterial Colonization.

Autor: Oliver-Cervelló L; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain., López-Gómez P; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain., Martin-Gómez H; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain., Marion M; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain., Ginebra MP; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain.; Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain.; Institute for Bioengineering of Catalonia (IBEC), Barcelona, 08028, Spain., Mas-Moruno C; Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, 08019, Spain.; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, 08019, Spain.; Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, 28029, Spain.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Aug 22; Vol. 30 (47), pp. e202400855. Date of Electronic Publication: 2024 Aug 02.

Human lactoferrin in the milk of transgenic mice increases intestinal growth in ten-day-old suckling neonates

Autor: P, Zhang, V, Sawicki, A, Lewis, L, Hanson, J H, Nuijens, M C, Neville

Publikováno v: Advances in experimental medicine and biology. 501

Regulatory roles and a signaling receptor have been proposed for the milk protein lactoferrin (Lf), but none has been definitively characterized. Nichols and colleagues (1987) observed that human lactoferrin (hLf) stimulated thymidine incorporation i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa283660d89f8d2e920d66041b03009a
https://pubmed.ncbi.nlm.nih.gov/11787671

Thrombin and human plasma kallikrein inhibition during simulated extracorporeal circulation block platelet and neutrophil activation

Autor: Y T, Wachtfogel, C, Kettner, C E, Hack, J H, Nuijens, T M, Reilly, R M, Knabb, U, Kucich, S, Niewiarowski, L H, Edmunds, R W, Colman

Publikováno v: Thrombosis and haemostasis. 80(4)

Cardiopulmonary bypass causes hemorrhagic complications, and initiates a chemical and cellular inflammatory response. Contact of blood with synthetic surfaces leads to qualitative and quantitative alterations in platelets, neutrophils, complement, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa6bd8611ab157c77af870a4a6e74479
https://pubmed.ncbi.nlm.nih.gov/9798991