Výsledky vyhledávání - "J H, McDonough"

Isoflurane anesthesia for guinea pigs (Cavia porcella) in a stereotaxic surgical apparatus

Autor: M C, Ross, L D, Zoeffel, J D, McMonagle, J H, McDonough

Publikováno v: Contemporary topics in laboratory animal science. 39(2)

Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) is a potent general anesthetic agent that is highly adaptable to use in small laboratory animal species. Respiratory delivery is easily accomplished in these animals, even during restrai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00d941863d513e31e6be4b9b53993bfa
https://pubmed.ncbi.nlm.nih.gov/11476062

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Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

Autor: Tsung-Ming Shih, J. H. McDonough

Publikováno v: Archives of toxicology. 74(3)

The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec22fa564204e0ff19782c507238322
https://pubmed.ncbi.nlm.nih.gov/10877003

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Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by the nerve agent soman

Autor: J H, McDonough, T R, Clark, T W, Slone, D, Zoeffel, K, Brown, S, Kim, C D, Smith

Publikováno v: Neurotoxicology. 19(3)

This study describes the neural structures damaged following exposure to the nerve agent soman, shows there are time-dependent differences in the extent of damage in certain structures, and relates seizure-induced increases in delta band (0-3.5 Hz) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::464ab409d3f7179a8aa4a528ba260832
https://pubmed.ncbi.nlm.nih.gov/9621344

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Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology

Autor: J H, McDonough, T M, Shih

Publikováno v: Neuroscience and biobehavioral reviews. 21(5)

This paper proposes a three phase "model" of the neuropharmacological processes responsible for the seizures and neuropathology produced by nerve agent intoxication. Initiation and early expression of the seizures are cholinergic phenomenon; antichol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a29d29c3e9a98126d5f70518daf0246
https://pubmed.ncbi.nlm.nih.gov/9353792

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Neurochemical mechanisms in soman-induced seizures

Autor: T M, Shih, J H, McDonough

Publikováno v: Journal of applied toxicology : JAT. 17(4)

This study examined brain regional neurotransmitter level changes as a function of seizure duration following soman intoxication. Rats, implanted with cortical electrodes and pretreated with HI-6, received a convulsant dose of soman. At selected time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::442433f3853e8a8f4934e38afec58fe9
https://pubmed.ncbi.nlm.nih.gov/9285539

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Gamma radiation-induced disruption in schedule-controlled performance in rats

Autor: P C, Mele, J H, McDonough

Publikováno v: Neurotoxicology. 16(3)

Adult male rats responded under a multiple fixed-interval 2-min, fixed-ratio 50 (multiple FI FR) schedule of milk delivery. Four groups of rats were given acute whole-body doses of 2.25, 4.5, 6.75, or 9.0 gray (Gy) of 60Co gamma-photon radiation; a f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eeb342154f37eb5767845a9de18146d7
https://pubmed.ncbi.nlm.nih.gov/8584281

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Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment

Autor: J H, McDonough, L W, Dochterman, C D, Smith, T M, Shih

Publikováno v: Neurotoxicology. 16(1)

Brain and cardiac tissue was examined for pathological changes from rats that survived 24 hrs following exposure to a convulsant dose of the nerve agent soman. The animals had been treated following varying durations of seizure activity (2.5 - 40 min

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82876f79456d51b5cf0138a0ccd5e9fa
https://pubmed.ncbi.nlm.nih.gov/7603632

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Soman-induced brain lesions demonstrated by muscarinic receptor autoradiography

Autor: L, Churchill, T L, Pazdernik, J L, Jackson, S R, Nelson, F E, Samson, J H, McDonough, C G, McLeod

Publikováno v: Neurotoxicology. 6(3)

Repeated exposure of rats to sublethal doses of soman resulted in moderate to severe symptoms of anticholinesterase intoxication and a pronounced weight loss within a small subgroup of these animals. A consistent pattern of cell loss and extensive ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15013272f5f924bd55db63cb537ca8e5
https://pubmed.ncbi.nlm.nih.gov/2413409

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Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology

Autor: J H, McDonough, N K, Jaax, R A, Crowley, M Z, Mays, H E, Modrow

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 13(2)

Toxic doses of the organophosphonate anticholinesterase agent soman can produce neural and cardiac lesions in animals that survive the acute poisoning. The ability of two standard antidote drugs, atropine and diazepam, along with the oxime pralidoxim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7509f46bbb44f08b2f281b396e1ccf92
https://pubmed.ncbi.nlm.nih.gov/2792594

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