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3-Amino-4-(2-((4-[18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitrile, an F-18 Fluorobenzyl Analogue of DASB: Synthesis, in Vitro Binding, and in Vivo Biodistribution Studies

Autor: Richard C. Minton, Shankar R. Thopate, Pradeep Garg, Kimberly W. Black, and Andrew J. H. Lynch, Sudha Garg

Publikováno v: Bioconjugate Chemistry. 18:1612-1618

3-amino-4-(2[11C]methylaminomethylphenylsulfanyl)benzonitrile (C-11 DASB) exhibits excellent in vitro and in vivo properties toward the serotonin transporter. If labeled with a longer physical half-life radioisotope, this ligand could be more attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1554428d2679936eb85d0360db837a
https://doi.org/10.1021/bc070112g

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Investigating the distribution of prostate cancer using three-dimensional computer simulation

Autor: Seong Ki Mun, Isabell A. Sesterhenn, M B Opell, Wei Zhang, Jianchao Zeng, Judd W. Moul, J H Lynch, John J. Bauer, Roger R. Connelly

Publikováno v: Prostate Cancer and Prostatic Diseases. 5:204-208

The objective of this work was to investigate the distribution of prostate cancer using three-dimensional (3-D) computer simulation. Two hundred and eighty-one 3-D computer prostate models were constructed from radical prostatectomy specimens. An alg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafaa1cb7121b3ad0c8ebcd59695f0b2
https://doi.org/10.1038/sj.pcan.4500577

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Limitations of reduced-field irradiated volume and technique in conventional radiation therapy of prostate cancer: implications for conformal 3-D treatment

Autor: G J, Gagnon, K W, Harter, C D, Berg, J H, Lynch, D R, Cornell, M R, Kuettel, A, Dritschilo

Publikováno v: International journal of cancer. 90(5)

In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced-field treatment factors, such as reduced-field (RF) irradiated volume, RF techniqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a51902c083aba10dc9dde295523b7ef7
https://pubmed.ncbi.nlm.nih.gov/11091350

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Treatment of female urethral carcinoma in medically inoperable patients using external beam irradiation and high dose rate intracavitary brachytherapy

Autor: M R, Kuettel, D S, Parda, K W, Harter, J E, Rodgers, J H, Lynch

Publikováno v: The Journal of urology. 157(5)

We developed and present our experience with high dose rate brachytherapy for treatment of carcinoma of the urethra in medically inoperable women.Since 1991, 4 women with localized urethral cancer, medically unable to undergo resection or interstitia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5c08c842cb0ef13e3269a080500f3e5
https://pubmed.ncbi.nlm.nih.gov/9112502

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The radiographic diagnosis of pelvic lipomatosis

Autor: R M, Mordkin, B J, Roberts, R, Vanderslice, J H, Lynch

Publikováno v: Techniques in urology. 3(4)

We describe a patient who initially presented with asymptomatic hydronephrosis. He underwent extensive radiologic evaluation which led to the diagnosis of pelvic lipomatosis. The possible etiology, workup, and treatment options of this unusual entity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eedbece1f23e1ebea84fed3de1027a25
https://pubmed.ncbi.nlm.nih.gov/9531109

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Management of locally advanced prostate cancer

Autor: R M, Mordkin, W S, Hayes, M R, Kuettel, J H, Lynch

Publikováno v: Oncology (Williston Park, N.Y.). 10(9)

The staging and treatment of prostate cancer are complex, particularly in patients with clinical disease that has advanced locally beyond the confines of the gland. Management choices are made more difficult by a paucity of quality randomized and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9afa3436c2ba008bc359d8522294c377
https://pubmed.ncbi.nlm.nih.gov/8882922

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Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein

Autor: D, Djakiew, B R, Pflug, R, Delsite, M, Onoda, J H, Lynch, G, Arand, E W, Thompson

Publikováno v: Cancer research. 53(6)

The migration of three human prostate tumor epithelial cell lines (TSU-pr1, PC-3, DU-145) in response to secreted protein from a human prostate stromal cell line was investigated by using the modified blind-well Boyden chamber assay. Migrated cells w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42a71c8cb0fc1be54930b5070d7130cd
https://pubmed.ncbi.nlm.nih.gov/8443820

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Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines

Autor: B R, Pflug, M, Onoda, J H, Lynch, D, Djakiew

Publikováno v: Cancer research. 52(19)

In the human prostate, a low affinity (p75) nerve growth factor (NGF) receptor (NGF-R) localizes to the epithelia while a NGF-like protein localizes to the stroma. This NGF-like ligand, derived from prostate stromal cell cultures, has been shown to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e055a8bf73c4e9d9f2948c4c019b294
https://pubmed.ncbi.nlm.nih.gov/1382843

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Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate

Autor: D, Djakiew, R, Delsite, B, Pflug, J, Wrathall, J H, Lynch, M, Onoda

Publikováno v: Cancer research. 51(12)

Nerve growth factor-like substance(s) were identified in both conditioned media of a human prostatic tumor epithelial cell line (TSU-pr1) and a human prostatic stromal cell line (HPS) by Western blot analysis and bioassay of neurite outgrowth of PC12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb769cf269f22fa4d3a7016db50c9f1e
https://pubmed.ncbi.nlm.nih.gov/1710170

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