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Residual host cell protein from continuous cell lines. Effect on the safety of protein pharmaceuticals

Autor: J H, Lupker

Publikováno v: Developments in biological standardization. 93

The presence of residual host cell proteins in protein pharmaceuticals obtained from continuous mammalian cell lines has been a point of concern. Clinical experience with different biopharmaceuticals shows that residual protein in these highly purifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ceac9b32a8c3122909f62e2f819a699
https://pubmed.ncbi.nlm.nih.gov/9737378

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Structure and Function of the Transforming Genes of Human Adenoviruses and SV40

Autor: P.I. Schrier, J. Maat, A. de Waard, C.P. van Beveren, J. H. Lupker, P.J. van den Elsen, R. J. DeLeys, H. van Ormondt, A. J. Van Der Eb, R. Dijkema, H. Jochemsen

Publikováno v: Cold Spring Harbor Symposia on Quantitative Biology. 44:383-399

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d986ec2dce77520545dadb3b5d71caa
https://doi.org/10.1101/sqb.1980.044.01.043

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An Escherichia coli Mutant with an Altered Elongation Factor Tu

Autor: J. H. Lupker, G. J. Verschoor, F. W. M. De Rooij, A. Rörsch, Leendert Bosch

Publikováno v: Proceedings of the National Academy of Sciences. 71:460-463

A thermosensitive mutant of Escherichia coli has been isolated that is unable to replicate the bacteriophage MS2 at 42° but permits phage production at 37°. Thermal inactivation studies of the supernatant enzymes show that this mutant contains a fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3263dbb07f937c96513700ad7de99915
https://doi.org/10.1073/pnas.71.2.460

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Identification and mapping of the early gene products of adenovirus type 12

Autor: A. J. Van Der Eb, J. H. Lupker, G.S.G. Daniels, H. Jochemsen

Publikováno v: Virology. 105:551-563

Cytoplasmic RNA was prepared from KB cells early after lytic infection with adenovirus type 12 and virus-specific RNAs were selected by hybridization to endo R· Hin dIII fragments of Ad12 DNA. The selected RNAs were translated in cell-free systems d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cce9f4c18890dd40dbe8452fe68b614
https://doi.org/10.1016/0042-6822(80)90055-0

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UV-reactivation, virus production and mutagenesis of SV40 in VU-irradiated monkey kidney cells

Autor: Jan Cornelis, J. H. Lupker, A. J. Van Der Eb

Publikováno v: Mutation research. 71(1)

The survival of UV-irradiated simian virus 40 (SV40) is higher in VU-irradiated than in non-irradiated monolayers of BSC-1 monkey cells. A similar reactivation is found when cells are infected with SV40-DNA, suggesting that reactivation acts on viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f7b649b08f366c263c768f93af46ec
https://pubmed.ncbi.nlm.nih.gov/6248777

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STRUCTURE AND ORGANIZATION OF ADENOVIRUS 5 TRANSFORMATION GENES

Autor: H. van Ormondt, J. H. Lupker, H. Jochemsen, C.P. van Beveren, A. J. Van Der Eb, P.J. van den Elsen, P.I. Schrier, J. Maat, A. de Waard

The results presented in this paper show that the transforming region of adenovirus 5 (Ad5) DNA can be divided into at least two parts, which each appear to have a distinct role in transformation. To obtain an understanding of the nature and organiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::425ac1f08bb236442040be23010f9f03
https://doi.org/10.1016/b978-0-12-198780-0.50020-9

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In vitro synthesis of adenovirus type 5 T antigens. II. Translation of virus-specific RNA from cells transformed by fragments of adenovirus type 5 DNA

Autor: J. H. Lupker, A. J. Van Der Eb, H. Jochemsen, J. J.L. Hertoghs, A Davis

Virus-specific cytoplasmic RNA was isolated from rat cell lines transformed by fragments of adenovirus type 5 DNA, and the RNAs were translated in cell-free systems derived from wheat germ or rabbit reticulocytes. RNA was isolated from cell lines tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02c13f199885b529545f1596ca3cc0
https://europepmc.org/articles/PMC171034/

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In vitro synthesis of adenovirus type 5 T antigens. I. Translation of early region 1-specific rna from lytically infected cells

Autor: A Davis, J. H. Lupker, H. Jochemsen, A. J. Van Der Eb

Publikováno v: Journal of virology. 37(1)

Translation of early RNA specific for the leftmost early region 1 of adenovirus type 5 DNA in a rabbit reticulocyte cell-free system resulted in the synthesis of proteins with the following molecular weights: 65,000 (65K), 54K, 42 to 34K, 29K, 25K, 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e92dfa9571af0201e657a1632684a90
https://pubmed.ncbi.nlm.nih.gov/7218430

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Structure and Functions of Adenovirus 5 Transformation Genes

Autor: J. H. Lupker, H. Jochemsen, P.I. Schrier, J. Maat, H. van Ormondt, A. J. Van Der Eb

Publikováno v: Genetic Origins of Tumor Cells ISBN: 9789400988255

Transformation by human adenoviruses is a process in which only a small part of the genome is involved. The transforming segment is localized at the left-hand end of the genome, between 1 and 11%, corresponding to the early region 1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69ae5a0c2d2f8beafcf2a69480fa43dd
https://doi.org/10.1007/978-94-009-8823-1_5

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