Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J H, Krystal"'
Publikováno v:
European Psychiatry, Vol 67, Pp S87-S88 (2024)
Introduction In a 12-week, Phase II (NCT02832037) trial, iclepertin (BI 425809), an inhibitor of glycine transporter-1, was generally well tolerated and significantly improved cognition in 509 patients with schizophrenia. Objectives The Phase III C
Externí odkaz:
https://doaj.org/article/63297ea1e8ba457985d3912a7d85d930
Publikováno v:
European Psychiatry, Vol 66, Pp S637-S637 (2023)
Introduction Cognitive impairment (CI) is a major determinant of poor functional outcome in schizophrenia and there are currently no available pharmacotherapies. Deficits in glutamatergic signalling play a key role in the neuropathology of cognitive
Externí odkaz:
https://doaj.org/article/736c3de390694142971e459fd0ccf07d
Autor:
D. C. D'Souza, J. H. Krystal
Publikováno v:
International Review of Psychiatry. 13:40-46
Psychopharmacological challenge studies have made significant contributions to understanding the neurobiological basis of psychiatric disorders. With the emergence of novel, sometimes alternative, techniques to study the neurobiology of psychiatric d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba2966147d1f2c4a786dda43e2d5a2
https://doi.org/10.1080/09540260123077
https://doi.org/10.1080/09540260123077
Publikováno v:
Alcoholism, clinical and experimental research. 25(8)
The capacity of alcohol cues to precipitate the desire to drink may be an important determinant of relapse to alcohol use in recovering alcohol-dependent patients. This study evaluated whether attenuation of serotonin synthesis via depletion of its p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a14f7847587314190032b4b1fcb6db4
https://pubmed.ncbi.nlm.nih.gov/11505046
https://pubmed.ncbi.nlm.nih.gov/11505046
Publikováno v:
Seminars in clinical neuropsychiatry. 4(4)
In this chapter we review trauma-related studies involving epinephrine (E), norepinephrine (NE), and serotonin (5-HT). Central catecholamine neurons seem to play a critical role in level of alertness, vigilance, orienting, selective attention, memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::622eb364766cf7e0d2ee44835f746abe
https://pubmed.ncbi.nlm.nih.gov/10553029
https://pubmed.ncbi.nlm.nih.gov/10553029
Publikováno v:
Seminars in clinical neuropsychiatry. 4(4)
Dissociative cognitive and perceptual alterations commonly occur at the time of traumatization and as an enduring feature of post-traumatic stress disorder (PTSD). After stress exposure, dissociative symptoms are a predictor of the development of PTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a79c7b9488b63da6b3cb411b3bdbf035
https://pubmed.ncbi.nlm.nih.gov/10553033
https://pubmed.ncbi.nlm.nih.gov/10553033
Autor:
J H, Krystal, D C, D'Souza, I L, Petrakis, A, Belger, R M, Berman, D S, Charney, W, Abi-Saab, S, Madonick
Publikováno v:
Harvard review of psychiatry. 7(3)
Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors and agonists of the glycine-B coagonist site of these receptors have been important tools for characterizing the contributions of NMDA receptor pathophysiology to a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5152427dc38f2124f9f042eea31890da
https://pubmed.ncbi.nlm.nih.gov/10483932
https://pubmed.ncbi.nlm.nih.gov/10483932
Publikováno v:
The Psychiatric quarterly. 69(1)
The relationship between creatine kinase (CK) and aggressive behavior was tested in 195 males consecutively admitted to a forensic hospital. Among patients receiving antipsychotic medication, the most violent patients had higher CK levels than less v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f16b491fdb0077afddbddad2370f71f0
https://pubmed.ncbi.nlm.nih.gov/9536476
https://pubmed.ncbi.nlm.nih.gov/9536476
Publikováno v:
Synapse (New York, N.Y.). 23(1)
There is considerable preclinical evidence for a relationship between noradrenergic brain systems and behaviors associated with stress and anxiety. The majority of noradrenergic neurons are located in the locus coeruleus (pons), with projections thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55684c2f912c7ffdd75dab6f212926ae
https://pubmed.ncbi.nlm.nih.gov/8723133
https://pubmed.ncbi.nlm.nih.gov/8723133
Publikováno v:
Synapse (New York, N.Y.). 23(1)
Studies in animals have shown a relationship between alterations in noradrenergic brain system function and behaviors of anxiety and fear. These findings have generated the hypothesis that the symptoms seen in patients with anxiety disorders may be r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c2538ef5e1f3d1af9af78116e68fc94
https://pubmed.ncbi.nlm.nih.gov/8723134
https://pubmed.ncbi.nlm.nih.gov/8723134