Výsledky vyhledávání

Renal endosomes contain angiotensin peptides, converting enzyme, and AT1Areceptors

Autor: Gabriel L. Navar, J. H. Kaysen, L. Gabriel Navar, Patricia L. Allen, Timothy G. Hammond, Katie C. O’Reilly, Li-Xian Zou, John D. Imig

Publikováno v: American Journal of Physiology-Renal Physiology. 277:F303-F311

Kidney cortex and proximal tubular angiotensin II (ANG II) levels are greater than can be explained on the basis of circulating ANG II, suggesting intrarenal compartmentalization of these peptides. One possible site of intracellular accumulation is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93141b5030898d8c85d027747f91ae9
https://doi.org/10.1152/ajprenal.1999.277.2.f303

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Myeloma light chains are ligands for cubilin (gp280)

Autor: F. O. Goda, Timothy G. Hammond, Pierre J. Verroust, J. H. Kaysen, F. Pontillon, Eric E. Simon, Wendy C. Campbell, Joanne Bruno, Gabriel L. Navar, Vecihi Batuman, Michelle Lyles

Publikováno v: American Journal of Physiology-Renal Physiology. 275:F246-F254

Although myeloma light chains are known to undergo receptor-mediated endocytosis in the kidney, the molecular identity of the receptor has not been characterized. We examined the interaction between cubilin (gp280) and four species of light chains is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3557ee9c13eed3bf0dee4a3e077a58b
https://doi.org/10.1152/ajprenal.1998.275.2.f246

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Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin

Autor: F. Pontillon, R. R. Majewski, Gabriel L. Navar, P. J. Verroust, J. H. Kaysen, F. O. Goda, Timothy G. Hammond

Publikováno v: American Journal of Physiology-Renal Physiology. 272:F117-F123

Megalin, a giant glycoprotein receptor heavily concentrated in the early endosomal pathway of renal proximal tubular cells, binds gentamicin with high affinity and delivers the drug to lysosomes. Utilizing an in vitro reconstitution assay we tested w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af87510afb4eedf6c9a72f2636e8a663
https://doi.org/10.1152/ajprenal.1997.272.1.f117

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Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets

Autor: J H Kaysen, Susan M. Moran, Michael J. MacDonald, C E Pomije

Publikováno v: Journal of Biological Chemistry. 266:22392-22397

It has been shown previously that glucose-induced insulin release is completely absent in rat pancreatic islets that had been cultured for 1 day at low glucose (1 mM) and that it is restored by culturing islets for a 2nd day at high (20 mM) glucose (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53d17bec3571f13d90bf667f054fb481
https://doi.org/10.1016/s0021-9258(18)54585-3

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Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets

Autor: Susan M. Moran, Debbie McKenzie, H C Towle, Michael J. MacDonald, Leonard A. Fahien, T M Walker, J H Kaysen

Publikováno v: Journal of Biological Chemistry. 266:1335-1340

Much evidence has accumulated to support the idea that leucine can stimulate insulin release by allosterically activating glutamate dehydrogenase thus enhancing glutamate metabolism. It is less clear how the metabolism of leucine itself contributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec7ed4fc06652111e3a384c399417b6
https://doi.org/10.1016/s0021-9258(17)35320-6

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Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets

Autor: Debbie McKenzie, J H Kaysen, Michael J. MacDonald, Teresa Walker

Publikováno v: Hormone and Metabolic Research. 24:158-160

Studies were performed to obtain evidence for glyconeogenesis from pyruvate to the triose phosphates in pancreatic islets. Inability to show this evidence would be consistent with the fact that glyceraldehyde, but not pyruvate, is a potent insulin se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60573b371182a623a4a2d77ac2d2524
https://doi.org/10.1055/s-2007-1003284

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Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle

Autor: K. C. O’Reilly, Patricia L. Allen, D. A. Wolf, T. J. Goodwin, Timothy G. Hammond, Edmund Benes, J. H. Kaysen, A. Taher, R. M. Linnehan

Publikováno v: Physiological genomics. 3(3)

Hammond, T. G., E. Benes, K. C. O’Reilly, D. A. Wolf, R. M. Linnehan, J. H. Kaysen, P. L. Allen, and T. J. Goodwin. Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle. Physiol Genomics 3: 163–173, 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b3ddf845110889d416b2e21864f68c
https://pubmed.ncbi.nlm.nih.gov/11015612

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Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder

Autor: X C, Wang, R, Saban, J H, Kaysen, M R, Saban, P L, Allen, E N, Benes, T G, Hammond

Publikováno v: The Journal of urology. 163(3)

The proteins which constitute the final common pathway linking receptors on cell surfaces to the inflammatory cascade have recently been identified and cloned. Central to activation of this inflammatory cascade is translocation from cytosol to nucleu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e63c976bd4155e629c93258cb31cb098
https://pubmed.ncbi.nlm.nih.gov/10688037

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