Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J H, Hochman"'
Publikováno v:
The Journal of Immunology. 146:1862-1867
Membrane class I MHC molecules of Con-A activated and lymphoma murine cells have been labeled by exchange of the cell's beta 2m with soluble fl-beta 2m. It has previously been shown that this method of labeling is specific and does not affect the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1350ce180395c9b6cfc6e05d2bb05d
https://doi.org/10.4049/jimmunol.146.6.1862
https://doi.org/10.4049/jimmunol.146.6.1862
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Two different cellular assay models were assessed as in vitro systems for P-glycoprotein (P-gp) substrate identification: cellular accumulation studies with KB-V1, a human MDR1 P-gp-overexpressing multidrug-resistant human epidermoid carcinoma cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::248d27206659500f6fb2cca79edbd28c
https://pubmed.ncbi.nlm.nih.gov/11181899
https://pubmed.ncbi.nlm.nih.gov/11181899
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(6)
Methylation at the 2-position of the imidazole ring of IBN (I), a 1, 5-substituted imidazole-containing compound, was carried out to minimize its inhibition of rat cytochrome P450 (CYP)3A activity. The resulting analog 2-MIBN (II) exhibited an inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ea161f896272171124139e7b347b331
https://pubmed.ncbi.nlm.nih.gov/10820141
https://pubmed.ncbi.nlm.nih.gov/10820141
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(1)
Caco-2 cells grown in the presence of 1alpha,25-di-OH vitamin D(3) (di-OH vit D(3)) were used as a model to evaluate the effects of P-glycoprotein (Pgp) efflux on CYP3A4-mediated metabolism of indinavir during intestinal absorption. Caco-2 cells grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4aa78169b7c43fd16607aea7f515db41
https://pubmed.ncbi.nlm.nih.gov/10604964
https://pubmed.ncbi.nlm.nih.gov/10604964
Autor:
T, Prueksaritanont, L M, Gorham, J D, Ellis, C, Fernandez-Metzler, P, Deluna, J R, Gehret, K L, Strong, J H, Hochman, B C, Askew, M E, Duggan, J D, Gilbert, J H, Lin, K P, Vyas
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(11)
The pharmacokinetics and bioavailability of L-751,164, an ethyl ester prodrug of a potent fibrinogen receptor antagonist, L-742,998, were studied in beagle dogs and rhesus monkeys. In both species, L-751,164 exhibited high clearance. After an intrave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a21deb0676661bffbaf88aad293d60d
https://pubmed.ncbi.nlm.nih.gov/8937862
https://pubmed.ncbi.nlm.nih.gov/8937862
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(6)
Drug-metabolizing enzymes were studied in subcellular fractions of dog, monkey, and human small intestines, and in the human adenocarcinoma cell line Caco-2, a commonly used in vitro absorption model. Immunoblot analysis indicated the presence of enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efc1428a2d33c07df26c786eff9040fa
https://pubmed.ncbi.nlm.nih.gov/8781778
https://pubmed.ncbi.nlm.nih.gov/8781778
Publikováno v:
Pharmaceutical biotechnology. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83414b1556eaff020c78d1cd6e4ac1d5
https://pubmed.ncbi.nlm.nih.gov/8791809
https://pubmed.ncbi.nlm.nih.gov/8791809
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(2)
Long-chain acylcarnitines (12-18 carbon fatty acid esters) dramatically enhance the absorption of hydrophilic drugs across intestinal mucosa without altering the morphology of the epithelium. The mechanism underlying these effects was studied using t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82c47b0476353afe1b8f888116349f74
https://pubmed.ncbi.nlm.nih.gov/8182550
https://pubmed.ncbi.nlm.nih.gov/8182550
Publikováno v:
Pharmaceutical research. 9(3)
A simple modification of the commercially available Sweetana-Grass (S-G) side-by-side diffusion cells, allowing the simultaneous measurement of tissue permeability and transepithelial electrical resistance (TEER), has been described and validated for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9508131e68aa394ce1e03307673b98a0
https://pubmed.ncbi.nlm.nih.gov/1614963
https://pubmed.ncbi.nlm.nih.gov/1614963
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(6)
Membrane class I MHC molecules of Con-A activated and lymphoma murine cells have been labeled by exchange of the cell's beta 2m with soluble fl-beta 2m. It has previously been shown that this method of labeling is specific and does not affect the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71d141d03e2687c0f58d792fb75bf8b8
https://pubmed.ncbi.nlm.nih.gov/2005381
https://pubmed.ncbi.nlm.nih.gov/2005381