Zobrazeno 1 - 10
of 24
pro vyhledávání: '"J H, Goodman"'
Publikováno v:
NeuroToxicology. 59:9-21
The hippocampus maintains a capacity for neurogenesis throughout life, a capacity that is reduced in models of adult onset hypothyroidism. The effects of developmental thyroid hormone (TH) insufficiency on neurogenesis in the adult hippocampus, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082928b9ced2e5a7708d3ad80d09f75d
https://doi.org/10.1016/j.neuro.2016.12.009
https://doi.org/10.1016/j.neuro.2016.12.009
Publikováno v:
Journal of neuroendocrinology. 26(8)
Thyroid hormones (TH) play crucial roles in brain maturation and are important for neuronal migration and neocortical lamination. Subcortical band heterotopia (SBH) represent a class of neuronal migration errors in humans that are often associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84183b95720056979f1d42bc2a539a33
https://pubmed.ncbi.nlm.nih.gov/24889016
https://pubmed.ncbi.nlm.nih.gov/24889016
Publikováno v:
Amino Acids. 19:283-297
In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism. Evidence for a physiological rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296f7cf3352caa557962998788cb4c63
https://doi.org/10.1007/s007260070060
https://doi.org/10.1007/s007260070060
Autor:
M G Goodman, J H Goodman
Publikováno v:
The Journal of Immunology. 153:4081-4087
We have previously described a class of immunostimulatory ribonucleoside, exemplified by loxoribine (7-allyl-8-oxoguanosine) and 8-bromoguanosine, that act on cycling B cells to promote nonspecific proliferation and differention, and that synergize w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7572543fae15d04258908877476de835
https://doi.org/10.4049/jimmunol.153.9.4081
https://doi.org/10.4049/jimmunol.153.9.4081
Autor:
L. E. Burr, Erika Chourmouzis, Michael G. Goodman, D C Argentieri, Dieter H. Klaubert, Stanley C Bell, J. Come, B L Pope, J H Goodman, A B Reitz
Publikováno v:
Journal of Medicinal Chemistry. 37:3561-3578
A series of 7,8-disubstituted guanosine derivatives was designed and prepared as potential B-cell-selective activators of the humoral immune response. These compounds were evaluated for their ability to act as B-cell mitogens and to augment the antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6172029e5bdf9327aed72febe0dbed3
https://doi.org/10.1021/jm00047a014
https://doi.org/10.1021/jm00047a014
Autor:
Marianne S. Rampulla, Barbara L. Pope, D C Argentieri, Reitz Allen B, Stanley C. Bell, Dieter H. Klaubert, Robert Chen, Mary R. Schott, L. E. Burr, Michael G. Goodman, Bruce E. Maryanoff, J H Goodman, J. Come
Publikováno v:
ChemInform. 26
7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of guanosine derivatives for further evaluation as an immunostimulant. Numerous related analogs were also synthesized and evaluated: 2′,3′-ketals of 5 are particularly interesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818604bd5976e742bb4a1712112cc25b
https://doi.org/10.1002/chin.199502193
https://doi.org/10.1002/chin.199502193
Autor:
Mario Varasi, G. Ceresoli-Borroni, Robert Schwarcz, Paolo Guidetti, Carmela Speciale, Helen E. Scharfman, J. H. Goodman, Hui-Qiu Wu
Publikováno v:
Neuroscience. 97(2)
Competing enzymatic mechanisms degrade the tryptophan metabolite l -kynurenine to kynurenate, an inhibitory and neuroprotective compound, and to the neurotoxins 3-hydroxykynurenine and quinolinate. Kynurenine 3-hydroxylase inhibitors such as PNU 1565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577734e3ab8955fda8af40ea82f9c56
https://pubmed.ncbi.nlm.nih.gov/10799756
https://pubmed.ncbi.nlm.nih.gov/10799756
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(13)
This study examined the acute actions of brain-derived neurotrophic factor (BDNF) in the rat dentate gyrus after seizures, because previous studies have shown that BDNF has acute effects on dentate granule cell synaptic transmission, and other studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc4634bd8113baa08a59c8f1358d6c44
https://pubmed.ncbi.nlm.nih.gov/10377368
https://pubmed.ncbi.nlm.nih.gov/10377368
Publikováno v:
Journal of neurophysiology. 80(6)
Scharfman, H. E., J. H. Goodman, F. Du, and R. Schwarcz. Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)–induced entorhinal neuron loss. J. Neurophysiol. 80: 3031–3046, 1998. Synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf2085b477fd633e28a679dfb974f62
https://pubmed.ncbi.nlm.nih.gov/9862904
https://pubmed.ncbi.nlm.nih.gov/9862904
Publikováno v:
Journal of neuro-oncology. 33(1-2)
Boronophenylalanine (BPA) has been used for boron neutron capture therapy (BNCT) of brain tumors in both experimental animals and humans. The purpose of the present study was to determine if the efficacy of BNCT could be enhanced by means of intracar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d02e3aed58d879431c4cc801e3ec5fd7
https://pubmed.ncbi.nlm.nih.gov/9151224
https://pubmed.ncbi.nlm.nih.gov/9151224