Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J H, Fleisch"'
Autor:
D W, Snyder, N J, Bach, R D, Dillard, S E, Draheim, D G, Carlson, N, Fox, N W, Roehm, C T, Armstrong, C H, Chang, L W, Hartley, L M, Johnson, C R, Roman, A C, Smith, M, Song, J H, Fleisch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which
Autor:
W T, Jackson, L L, Froelich, R J, Boyd, J P, Schrementi, D L, Saussy, R M, Schultz, J S, Sawyer, M J, Sofia, D K, Herron, T, Goodson, D W, Snyder, P A, Pechous, S M, Spaethe, C R, Roman, J H, Fleisch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(1)
The in vitro actions were investigated of LY293111, a potent and selective leukotriene B4 (LTB4) receptor antagonist, on human neutrophils, human blood fractions, guinea pig lung membranes, and guinea pig parenchymal and tracheal strips. The IC50 for
Autor:
C. R. Roman, Michael J. Sofia, Baldwin Rf, Sandra L. Cockerham, S. A. Silbaugh, K. Nelson, Larry L. Froelich, P. Marder, Floreancig Paul Edward, Stephen Richard Baker, P. W. Stengel, Jason Scott Sawyer, S. M. Spaethe, D. L. Saussy, J. H. Fleisch, W. T. Jackson, Bach Nicholas J
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
Leukotriene B4 (LTB4) has been implicated as a key pro-inflammatory mediator in human diseases such as asthma, inflammatory bowel disease, psoriasis and arthritis (1). LTB4’s role in human disease is supported by the fact that via G-protein coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ac724edeb191b804e43ef5b753a2f4
https://doi.org/10.1007/978-1-4615-5325-0_51
https://doi.org/10.1007/978-1-4615-5325-0_51
Autor:
M J, Sofia, P, Floreancig, N, Bach, S R, Baker, K, Nelson, J S, Sawyer, R, Baldwin, S L, Cockerham, J H, Fleisch, L L, Froelich, W T, Jackson, P, Marder, C R, Roman, D L, Saussy, S A, Silbaugh, S M, Spaethe, P W, Stengel
Publikováno v:
Advances in experimental medicine and biology.
Autor:
J H, Fleisch, C T, Armstrong, C R, Roman, E D, Mihelich, S M, Spaethe, W T, Jackson, J L, Bobbitt, S, Draheim, N J, Bach, R D, Dillard, M, Martinelli, R, Fouts, D W, Snyder
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(1)
The primary objective of this study was to develop a functional assay that could provide rapid and reliable information on some pharmacologic characteristics of a novel inhibitor of human secretory phospholipase A2 (sPLA2). Guinea pig bronchoalveolar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(2)
The present investigation examined the pharmacologic profiles of three distinct guinea pig lung parenchymal strips (LPS): intact LPS, denuded LPS (devoid of any lung pleura) and pleural surface strips. All three preparations responded similarly to in
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 230(3)
The method of Katayama et al. (Microbiol. Immunol. 22:89-101, 1978) for assessing cutaneous vascular permeability was modified and used to evaluate responses of the dermal vasculature to histamine, leukotriene (LT)C4, LTD4 and the ionophore A23187. T
Publikováno v:
Drugs under experimental and clinical research. 14(5)
A series of chlorophenoxyalkyl acids were prepared and evaluated as pharmacological antagonists of leukotriene D4. Structure-activity relationship studies pointed to LY137617 as a compound with possible therapeutic value. In experiments on isolated s
Autor:
J H, Fleisch, K D, Haisch, S M, Spaethe, L E, Rinkema, G J, Cullinan, M J, Schmidt, W S, Marshall
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 229(3)
LY83583 , a quinolinedione , and LY151364 , a quinoxalinedione , were developed as inhibitors of leukotriene (slow reacting substance of anaphylaxis) release. They preferentially inhibited the release of leukotrienes over histamine from fragmented gu
Autor:
J H, Fleisch
Publikováno v:
Blood vessels. 11(4)