Výsledky vyhledávání - "J H, Fechner"

Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation

Autor: S J, Knechtle, M M, Hamawy, H, Hu, J H, Fechner, C S, Cho

Publikováno v: Immunological reviews. 183

Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5e0442393768c0da31d2fa947b28f2c
https://pubmed.ncbi.nlm.nih.gov/11782258

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Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients

Autor: C S, Cho, L C, Burkly, J H, Fechner, A D, Kirk, T D, Oberley, Y, Dong, K G, Brunner, D, Peters, C N, Tenhoor, K, Nadeau, G, Yagci, N, Ishido, J M, Schultz, M, Tsuchida, M M, Hamawy, S J, Knechtle

Publikováno v: Transplantation. 72(4)

Several conventional forms of immunosuppression have been shown to antagonize the efficacy of anti-CD154 monoclonal antibody- (mAb) based costimulatory molecule blockade immunotherapy. Our objective was to determine if allograft recipients treated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6063f6903b0ced4b8ca1fd38c9e2eb7b
https://pubmed.ncbi.nlm.nih.gov/11544416

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Graft survival in a rhesus renal transplant model after immunotoxin-mediated T-cell depletion is enhanced by mycophenolate and steroids

Autor: J H, Fechner, Y, Dong, X, Hong, K G, Brunner, M, Tsuchida, D, Neville, J, Scharff, F, Lee, T D, Oberley, D, Peters, J M, Schultz, E R, Manthei, M M, Hamawy, S J, Knechtle

Publikováno v: Transplantation. 72(4)

Anti-CD3 immunotoxin (IT), a T-cell-depleting agent, prolongs survival of renal allografts in a rhesus monkey model without the need for long-term immunosuppression. In this study we sought to further prolong allograft survival by giving short-term c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1e9428e939cbd4e55bd49d182d4d610
https://pubmed.ncbi.nlm.nih.gov/11544415

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Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18

Autor: M M, Hamawy, M, Tsuchida, C S, Cho, E R, Manthei, J H, Fechner, S J, Knechtle

Publikováno v: Transplantation. 72(3)

The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival. The immunotoxin FN18-CRM9, composed of the anti-CD3 monoclonal antibody FN18 and the mutated diphtheria toxin CRM9, is useful for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3c612e2cfd9186336e05fc03763f3f2
https://pubmed.ncbi.nlm.nih.gov/11502982

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Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts

Autor: A S, Lagoo, P J, Buckley, L J, Burchell, D, Peters, J H, Fechner, M, Tsuchida, Y, Dong, X, Hong, K G, Brunner, T D, Oberley, M M, Hamawy, S J, Knechtle

Publikováno v: Transplantation. 70(6)

In our previously described primate renal allograft model, T cell ablation leads to long-term graft survival. The role of endothelial cell alteration in chronic rejection was examined in our model.Renal transplants were performed in rhesus monkeys us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b37c04fda07c5d9fc5e22fe36043f5ac
https://pubmed.ncbi.nlm.nih.gov/11014641

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HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies

Autor: W J, Burlingham, E, Jankowska-Gan, L, DeVito-Haynes, J H, Fechner, K T, Hogan, F H, Claas, A, Mulder, X, Wang, S, Ferrone

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(12)

Soluble MHC Ags and anti-Id (anti-anti-MHC) Abs have both been shown to inhibit MHC alloantigen-specific B cell responses in vivo. We hypothesized that some anti-idiotypic Abs function as divalent molecular mimics of soluble HLA alloantigen. To test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbff851e0225f5e79a9a51821f51e5cc
https://pubmed.ncbi.nlm.nih.gov/9862700

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Primate renal transplants using immunotoxin

Autor: S J, Knechtle, J H, Fechner, Y, Dong, S, Stavrou, D M, Neville, T, Oberley, P, Buckley, N, Armstrong, K, Rusterholz, X, Hong, M, Tsuchida, M M, Hamawy

Publikováno v: Surgery. 124(2)

T-lymphocyte depletion 7 days before transplantation with immunotoxin FN 18-CRM9 has resulted in tolerance to subsequent renal allografts. We tested the effect of giving immunotoxin on the day of the transplantation and evaluated its effect on rhesus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10830ba8d68d40006800d221b5d9e29c
https://pubmed.ncbi.nlm.nih.gov/9706169

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Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms

Autor: S J, Knechtle, J, Wang, C, Graeb, Y, Zhai, X, Hong, J H, Fechner, E K, Geissler

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(1)

Our purposes were 1) to determine whether direct transfer of cDNA encoding allogeneic MHC class I Ag to the rat thymus would be capable of inducing donor-specific unresponsiveness and 2) to study the immunologic mechanism of this effect. Plasmid DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::985742597411a3241c340ddfef585203
https://pubmed.ncbi.nlm.nih.gov/9200450

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Split tolerance induced by immunotoxin in a rhesus kidney allograft model

Autor: J H, Fechner, D J, Vargo, E K, Geissler, C, Graeb, J, Wang, M J, Hanaway, D I, Watkins, M, Piekarczyk, D M, Neville, S J, Knechtle

Publikováno v: Transplantation. 63(9)

Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6647a86143a97e433cd4a17940fd7648
https://pubmed.ncbi.nlm.nih.gov/9158030

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