Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J H, Capdevila"'
Autor:
Shouzou Wei, Bruce D. Hammock, J. H. Capdevila, J. R. Snapper, Darryl C. Zeldin, John R. Falck
Publikováno v:
Archives of Biochemistry and Biophysics. 316:443-451
The metabolism of cis-epoxyeicosatrienoic acids (EETs), methyl cis-epoxyeicosatrienoates, and cis-epoxyeicosanoic acids by cytosolic epoxide hydrolase was studied to identify substrate structural features important for stereoselective metabolism and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f01df3f26edabe66362524b680753e
https://doi.org/10.1006/abbi.1995.1059
https://doi.org/10.1006/abbi.1995.1059
Publikováno v:
Journal of Biological Chemistry. 269:3387-3396
Two cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in chick embryo liver microsomes were purified. The P-450s exhibit catalytic selectivity either for arachidonic acid metabolism, particularly epoxygenation (P-450 TCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19378929e03f799fc74f4b068e81bbbc
https://doi.org/10.1016/s0021-9258(17)41874-6
https://doi.org/10.1016/s0021-9258(17)41874-6
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(3)
The function of cytochrome P450 (P450) in the mammalian brain is not well understood. In an effort to further this understanding, this study identifies two endogenous substrates for P450 2D18. Previous reports have shown that this isoform is expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75fe36bc0dc6668e53ffd9e9dfd96598
https://pubmed.ncbi.nlm.nih.gov/10945868
https://pubmed.ncbi.nlm.nih.gov/10945868
Publikováno v:
Journal of lipid research. 41(2)
The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and omega/omega-1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade. The charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc1fc4f265d4effca83b29c178bd124
https://pubmed.ncbi.nlm.nih.gov/10681399
https://pubmed.ncbi.nlm.nih.gov/10681399
Publikováno v:
Molecular aspects of medicine. 20(1-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::421339c64427aa4912884b6f23d00f14
https://pubmed.ncbi.nlm.nih.gov/10575651
https://pubmed.ncbi.nlm.nih.gov/10575651
Publikováno v:
The Journal of biological chemistry. 269(5)
Two cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in chick embryo liver microsomes were purified. The P-450s exhibit catalytic selectivity either for arachidonic acid metabolism, particularly epoxygenation (P-450 TCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23848a67e4d99fd3ab3f00ed7808a786
https://pubmed.ncbi.nlm.nih.gov/8106378
https://pubmed.ncbi.nlm.nih.gov/8106378
Autor:
A, Karara, K, Makita, H R, Jacobson, J R, Falck, F P, Guengerich, R N, DuBois, J H, Capdevila
Publikováno v:
The Journal of biological chemistry. 268(18)
A cDNA containing an open reading frame coding for the rat kidney cytochrome P-450 arachidonic acid epoxygenase was isolated from a male rat kidney cDNA library. Sequence analysis showed that with the exception of 11 nucleotides, this cDNA is identic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a65d01a52e767b9510cc3b2c82c46137
https://pubmed.ncbi.nlm.nih.gov/8514789
https://pubmed.ncbi.nlm.nih.gov/8514789
Autor:
J H, Capdevila, S, Wei, J, Yan, A, Karara, H R, Jacobson, J R, Falck, F P, Guengerich, R N, DuBois
Publikováno v:
The Journal of biological chemistry. 267(30)
The rat kidney microsomal epoxygenase catalyzed the asymmetric epoxidation of arachidonic acid to generate as major products: 8(R),9(S)-, 11(R),12(S)- and 14(S),15(R)-epoxyeicosatrienoic acids with optical purities of 97, 88, and 70%, respectively. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1bde48c12021a51982bdbe8c49545d0
https://pubmed.ncbi.nlm.nih.gov/1400482
https://pubmed.ncbi.nlm.nih.gov/1400482
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 6(2)
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e89b398706e232439b18af6d8cd8baae
https://pubmed.ncbi.nlm.nih.gov/1537463
https://pubmed.ncbi.nlm.nih.gov/1537463
Publikováno v:
The Journal of biological chemistry. 266(12)
By chromatographic and mass spectral techniques we document in rat liver the presence of new classes of glycerophospholipids which contain an epoxyeicosatrienoate moiety, esterified to the glycerol-sn-2 position. These novel lipids are formed in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad7ec7968ee8734b2f8ca90060625115
https://pubmed.ncbi.nlm.nih.gov/1902222
https://pubmed.ncbi.nlm.nih.gov/1902222