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Cell migration during heart regeneration in zebrafish

Autor: Yasuhiko Kawakami, Michael J. H. Brush, Naoyuki Tahara

Publikováno v: Developmental Dynamics. 245:774-787

Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2f2fac09b622069414cd6768a949e59
https://doi.org/10.1002/dvdy.24411

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Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine–Quinolone Carboxamides

Autor: Kathryn L. Trautman, Alex C. D. Salyer, Balaji Pathakumari, Michael J. H. Brush, Collin J Gustafson, Mallesh Beesu, Janardhan Banothu, Sunil A. David, Ziwei Hu

[Image: see text] Using a multiplexed, reporter gene-based, high-throughput screen, we identified 9-fluoro-7-hydroxy-3-methyl-5-oxo-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide as a TLR2 agonist. Preliminary struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51363c4d81eb013982231f79267900d8
https://europepmc.org/articles/PMC6331173/

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Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue

Autor: Bart N. Lambrecht, Ans De Beuckelaer, Kim Deswarte, Yupeng Li, Bruno G. De Geest, Euna Yoo, Sunil A. David, Stefan Lienenklaus, Nikunj M. Shukla, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer

Publikováno v: Bioconjugate chemistry. 29(8)

Immunogens carried in lymphatic fluid drain via afferent vessels into regional lymph nodes and facilitate the efficient induction of appropriate immune responses. The lymphatic system possesses receptors recognizing hyaluronic acid (HA). Covalent con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d212b72d216be726f1eb49f50950d0
https://pubmed.ncbi.nlm.nih.gov/29969553

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Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines

Autor: Alex C. D. Salyer, Justin K. Hill, Sunil A. David, Kathryn L. Trautman, Mallesh Beesu, Michael J. H. Brush

Publikováno v: Journal of medicinal chemistry. 60(5)

The induction of toll-like receptor 7 (TLR7)-dependent type I interferons (IFN-α/β) from plasmacytoid dendritic cells as well as the production of TLR8-dependent type II interferon (IFN-γ), TNF-α, and IL-12 in myeloid dendritic cells are of impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9835c152f4d56b8d481e268d8af67e7
https://pubmed.ncbi.nlm.nih.gov/28146629

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Cover Anomalous effects of sunglint on the AVHRR in the NOAA-12 satellite

Autor: R. J. H. Brush

Publikováno v: International Journal of Remote Sensing. 14:629-634

An effect has been observed in the channel 4 output of the NOAA-12 satellite which has not been observed from previous satellites in the NOAA series. Essentially, when sunglint is being observed by channels 1–3, and especially when channel 3 is sat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8c1d03965b210d474346191984c11d6
https://doi.org/10.1080/01431169308904364

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The navigation of AVHRR imagery

Autor: R. J. H. Brush

Publikováno v: International Journal of Remote Sensing. 9:1491-1502

One of the difficulties encountered in dealing with AVHRR imagery is that of navigating the data with an acceptable degree of precision. This paper describesa method, based on satelliteephemeris, which allowsaccurately gridded hard copy images to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ab36f0286b3897e181f0061f0ae3d92
https://doi.org/10.1080/01431168808954954

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