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Akademický článek

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

Autor: Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll

Publikováno v: eLife, Vol 13 (2024)

Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as e

Externí odkaz: https://doaj.org/article/c7cece9d67354cd59c1a7a7f1b5a4181

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Akademický článek

Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers

Autor: Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are

Externí odkaz: https://doaj.org/article/7789921720d54283b486c645e8eba774

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Intermediate Filaments Associate with Aggresome-like Structures in ProteostressedC. elegansNeurons and Influence Large Vesicle Extrusions as Exophers

Autor: Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C.Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll

Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results from proteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd67597b046726c06f36991d5d63358
https://doi.org/10.1101/2022.08.03.501714

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Akademický článek

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Overview of the TJ-II stellarator research programme towards model validation in fusion plasmas

Autor: C. Hidalgo, E. Ascasíbar, D. Alegre, A. Alonso, J. Alonso, R. Antón, A. Baciero, J. Baldzuhn, J.M. Barcala, L. Barrera, E. Blanco, J. Botija, L. Bueno, S. Cabrera, A. de Castro, E. de la Cal, I. Calvo, A. Cappa, D. Carralero, R. Carrasco, B. Carreras, R. Castro, L. Cebrián, A.A. Chmyga, M. Chamorro, P. Colino, F. de Aragón, M. Drabinskiy, J. Duque, L. Eliseev, F.J. Escoto, T. Estrada, M. Ezzat, F. Fraguas, D. Fernández-Ruiz, J.M. Fontdecaba, A. Gabriel, D. Gadariya, L. García, I. García-Cortés, R. García-Gómez, J.M. García-Regaña, A. González-Jerez, G. Grenfell, J. Guasp, V. Guisse, J. Hernández-Sánchez, J. Hernanz, A. Jiménez-Denche, P. Khabanov, N. Kharchev, R. Kleiber, F. Koechl, T. Kobayashi, G. Kocsis, M. Koepke, A.S. Kozachek, L. Krupnik, F. Lapayese, M. Liniers, B. Liu, D. López-Bruna, B. López-Miranda, U. Losada, E. de la Luna, S.E. Lysenko, F. Martín-Díaz, G. Martín-Gómez, E. Maragkoudakis, J. Martínez-Fernández, K.J. McCarthy, F. Medina, M. Medrano, A.V. Melnikov, P. Méndez, F.J. Miguel, B. van Milligen, A. Molinero, G. Motojima, S. Mulas, Y. Narushima, M. Navarro, I. Nedzelskiy, R. Nuñez, M. Ochando, S. Ohshima, E. Oyarzábal, J.L. de Pablos, F. Palomares, N. Panadero, F. Papoušek, F. Parra, C. Pastor, I. Pastor, A. de la Peña, R. Peralta, A. Pereira, P. Pons-Villalonga, H. Polaino, A.B. Portas, E. Poveda, F.J. Ramos, G.A. Rattá, M. Redondo, C. Reynoso, E. Rincón, C. Rodríguez-Fernández, L. Rodríguez-Rodrigo, A. Ros, E. Sánchez, J. Sánchez, E. Sánchez-Sarabia, S. Satake, J.A. Sebastián, R. Sharma, N. Smith, C. Silva, E.R. Solano, A. Soleto, M. Spolaore, T. Szepesi, F.L. Tabarés, D. Tafalla, H. Takahashi, N. Tamura, H. Thienpondt, A. Tolkachev, R. Unamuno, J. Varela, J. Vega, J.L. Velasco, I. Voldiner, S. Yamamoto, null the TJ-II Team

Publikováno v: Nuclear Fusion
Nuclear fusion 62 (2022): 042025-1–042025-14. doi:10.1088/1741-4326/ac2ca1
info:cnr-pdr/source/autori:Hidalgo, C.; Ascasibar, E.; Alegre, D.; Alonso, A.; Alonso, J.; Anton, R.; Baciero, A.; Baldzuhn, J.; Barcala, J. M.; Barrera, L.; Blanco, E.; Botija, J.; Bueno, L.; Cabrera, S.; de Castro, A.; de la Cal, E.; Calvo, I; Cappa, A.; Carralero, D.; Carrasco, R.; Carreras, B.; Castro, R.; de Castro, A.; Cebrian, L.; Chmyga, A. A.; Chamorro, M.; Colino, P.; de Aragon, F.; Drabinskiy, M.; Duque, J.; Eliseev, L.; Escoto, F. J.; Estrada, T.; Ezzat, M.; Fraguas, F.; Fernandez-Ruiz, D.; Fontdecaba, J. M.; Gabriel, A.; Gadariya, D.; Garcia, L.; Garcia-Cortes, I; Garcia-Gomez, R.; Garcia-Regana, J. M.; Gonzalez-Jerez, A.; Grenfell, G.; Guasp, J.; Guisse, V; Hernandez-Sanchez, J.; Hernanz, J.; Jimenez-Denche, A.; Khabanov, P.; Kharchev, N.; Kleiber, R.; Koechl, F.; Kobayashi, T.; Kocsis, G.; Koepke, M.; Kozachek, A. S.; Krupnik, L.; Lapayese, F.; Liniers, M.; Liu, B.; Lopez-Bruna, D.; Lopez-Miranda, B.; Losada, U.; de la Luna, E.; Lysenko, S. E.; Martin-Diaz, F.; Martin-Gomez, G.; Maragkoudakis, E.; Martinez-Fernandez, J.; McCarthy, K. J.; Medina, F.; Medrano, M.; Melnikov, A., V; Mendez, P.; Miguel, F. J.; van Milligen, B.; Molinero, A.; Motojima, G.; Mulas, S.; Narushima, Y.; Navarro, M.; Nedzelskiy, I; Nunez, R.; Ochando, M.; Ohshima, S.; Oyarzabal, E.; de Pablos, J. L.; Palomares, F.; Panadero, N.; Papousek, F.; Parra, F.; Pastor, C.; Pastor, I; de la Pena, A.; Peralta, R.; Pereira, A.; Pons-Villalonga, P.; Polaino, H.; Portas, A. B.; Poveda, E.; Ramos, F. J.; Ratta, G. A.; Redondo, M.; Reynoso, C.; Rincon, E.; Rodriguez-Fernandez, C.; Rodriguez-Rodrigo, L.; Ros, A.; Sanchez, E.; Sanchez, J.; Sanchez-Sarabia, E.; Satake, S.; Sebastian, J. A.; Sharma, R.; Smith, N.; Silva, C.; Solano, E. R.; Soleto, A.; Spolaore, M.; Szepesi, T.; Tabares, F. L.; Tafalla, D.; Takahashi, H.; Tamura, N.; Thienpondt, H.; Tolkachev, A.; Unamuno, R.; Varela, J.; Vega, J.; Velasco, J. L.; Voldiner, I; Yamamoto, S./titolo:Overview of the TJ-II stellarator research programme towards model validation in fusion plasmas/doi:10.1088%2F1741-4326%2Fac2ca1/rivista:Nuclear fusion/anno:2022/pagina_da:042025-1/pagina_a:042025-14/intervallo_pagine:042025-1–042025-14/volume:62

TJ-II stellarator results on modelling and validation of plasma flow asymmetries due to on-surface potential variations, plasma fuelling physics, Alfvén eigenmodes (AEs) control and stability, the interplay between turbulence and neoclassical (NC) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf2457984a81d77772505a2fa1167ab
https://hdl.handle.net/21.11116/0000-000A-79AB-E21.11116/0000-000A-79AD-C

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Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling

Autor: Monica Driscoll, Barth D. Grant, Meghan Lee Arnold, Ryan J. Guasp, Jason F Cooper

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249fd4c969248c1b2ec77969cc9aa39
http://europepmc.org/articles/PMC8433523

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Beam transmission dependence on beam parameters for TJ-II Neutral Beam Injectors

Autor: Beatriz Rojo, J. Guasp, José Antonio Sebastián, Julius Damba, E. Ascasíbar, Gilles Wolfers, R. Carrasco, Emilio Sánchez, Francisco Miguel, Fernando Martín, Macarena Liniers, A. Soleto

Publikováno v: Fusion Engineering and Design. 123:259-262

In Neutral Beam Heated plasmas, Beam transmission must be carefully evaluated in plasma experiments involving NBI parameter scans. In the TJ-II stellarator a number of experiments have been carried out in which the beam energy (Vaccel) is changed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dff90d3e30eb97d80729376da375c04e
https://doi.org/10.1016/j.fusengdes.2017.05.104

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A New Numerical Technique for the Inverse Problem in Thomson Scattering and Its Application to Experimental and Synthetic Spectra

Autor: Francisco Castejón, I. Pastor, R. F. Álvarez-Estrada, J. Guasp

Publikováno v: Fusion Science and Technology. 72:99-119

The inverse problem for Thomson scattering (TS), that is, finding the electron distribution function (EDF), not restricted to be Maxwellian or isotropic, from the observation of the scattered spectrum, is addressed. Based on previous results by the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6e537e52fbec0f5bab99f7e387da6bc
https://doi.org/10.1080/15361055.2017.1320497

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Nonlinear relativistic electron Thomson Scattering for laser radiation with orbital angular momentum

Autor: Francisco Castejón, I. Pastor, J. Guasp, L Roso, R. F. Álvarez-Estrada

Publikováno v: Journal of Physics Communications. 4:065010

The classical nonlinear incoherent Thomson Scattering (TS) power spectrum from free relativistic electrons moving in a laser beam with orbital angular momentum (OAM) is investigated. The main focus in this paper is on the TS process as a diagnostic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a8e7f7bd3eed0f3f9aae42311bc095b
https://doi.org/10.1088/2399-6528/ab9afa

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