Zobrazeno 1 - 10
of 523
pro vyhledávání: '"J Groffen"'
Autor:
Marieke Meijer, Miriam Öttl, Jie Yang, Aygul Subkhangulova, Avinash Kumar, Zicheng Feng, Torben W. van Voorst, Alexander J. Groffen, Jan R. T. van Weering, Yongli Zhang, Matthijs Verhage
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against this scenario. In a novel mouse model, tomosyn-1/2 deficiency lowered the fusion b
Externí odkaz:
https://doaj.org/article/9e5ac04838014cfc9c47148fbd0d6295
Akademický článek
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Autor:
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen
Publikováno v:
eLife, Vol 6 (2017)
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs. Whether Doc2B functions as a calcium sensor akin to synaptotagmins, or in other calcium-indep
Externí odkaz:
https://doaj.org/article/e23939c8ae6d4a2682d309f3e34a85e8
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Raya Sorkin, Rashmi Voleti, Josep Rizo, Guy Brand, Emma Logtenberg, Melissa C. Piontek, Gijs J.L. Wuite, Wouter H. Roos, Margherita Marchetti, Alexander J. Groffen, Emma Kerklingh
Publikováno v:
Sorkin, R, Marchetti, M, Logtenberg, E, Piontek, M C, Kerklingh, E, Brand, G, Voleti, R, Rizo, J, Roos, W H, Groffen, A J & Wuite, G J L 2020, ' Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms ', Biophysical Journal, vol. 118, no. 3, pp. 643-656 . https://doi.org/10.1016/j.bpj.2019.12.021
Biophysical Journal, 118(3), 643-656. Biophysical Society
Biophysical Journal, 118(3), 643-656. CELL PRESS
Biophys J
Biophysical Journal, 118(3), 643-656. Biophysical Society
Biophysical Journal, 118(3), 643-656. CELL PRESS
Biophys J
Synaptotagmin-1 (Syt1) is a calcium sensor protein that is critical for neurotransmission and is therefore extensively studied. Here, we use pairs of optically trapped beads coated with SNARE-free synthetic membranes to investigate Syt1-induced membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9f406d103fb959991bea979af8e0a6
https://doi.org/10.1016/j.bpj.2019.12.021
https://doi.org/10.1016/j.bpj.2019.12.021
Autor:
Zhong Ping Feng, Alexander J. Groffen, Ya Chi Huang, Hong Shuo Sun, Michael Wu, Jacqueline N. Crawley, Lucy R. Osborne, Ekaterina Turlova, Nardos G. Tassew, Wenliang Chen, Marielle Deurloo, You Wei Lin, Philippe P. Monnier, Elaine Tam
Publikováno v:
Molecular Neurobiology
Deurloo, M H S, Turlova, E, Chen, W-L, Lin, Y W, Tam, E, Tassew, N G, Wu, M, Huang, Y-C, Crawley, J N, Monnier, P P, Groffen, A J A, Sun, H-S, Osborne, L R & Feng, Z-P 2019, ' Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models ', Molecular Neurobiology, vol. 56, no. 5, pp. 3313-3325 . https://doi.org/10.1007/s12035-018-1290-7
Molecular Neurobiology, 56(5), 3313-3325. Humana Press
Deurloo, M H S, Turlova, E, Chen, W L, Lin, Y W, Tam, E, Tassew, N G, Wu, M, Huang, Y C, Crawley, J N, Monnier, P P, Groffen, A J A, Sun, H S, Osborne, L R & Feng, Z P 2019, ' Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models ', Molecular Neurobiology, vol. 56, no. 5, pp. 3313-3325 . https://doi.org/10.1007/s12035-018-1290-7
Deurloo, M H S, Turlova, E, Chen, W-L, Lin, Y W, Tam, E, Tassew, N G, Wu, M, Huang, Y-C, Crawley, J N, Monnier, P P, Groffen, A J A, Sun, H-S, Osborne, L R & Feng, Z-P 2019, ' Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models ', Molecular Neurobiology, vol. 56, no. 5, pp. 3313-3325 . https://doi.org/10.1007/s12035-018-1290-7
Molecular Neurobiology, 56(5), 3313-3325. Humana Press
Deurloo, M H S, Turlova, E, Chen, W L, Lin, Y W, Tam, E, Tassew, N G, Wu, M, Huang, Y C, Crawley, J N, Monnier, P P, Groffen, A J A, Sun, H S, Osborne, L R & Feng, Z P 2019, ' Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models ', Molecular Neurobiology, vol. 56, no. 5, pp. 3313-3325 . https://doi.org/10.1007/s12035-018-1290-7
Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7q11.23) are neurodevelopmental disorders caused by the deletion and duplication, respectively, of ~ 25 protein-coding genes on chromosome 7q11.23. The general transcription factor 2I (GTF2I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90cb6dead4bff6df82c89ae9dd962a
https://research.vu.nl/en/publications/64cb023b-4fc6-4474-bf64-ed3a64b5a39e
https://research.vu.nl/en/publications/64cb023b-4fc6-4474-bf64-ed3a64b5a39e
Publikováno v:
Molecular and Cellular Neuroscience, 112:103613. Academic Press Inc.
Bourgeois-Jaarsma, Q, Miaja Hernandez, P & Groffen, A J 2021, ' Ca 2+ sensor proteins in spontaneous release and synaptic plasticity : Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons ', Molecular and Cellular Neuroscience, vol. 112, 103613 . https://doi.org/10.1016/j.mcn.2021.103613
Bourgeois-Jaarsma, Q, Miaja Hernandez, P & Groffen, A J 2021, ' Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons ', Molecular and Cellular Neuroscience, vol. 112, 103613 . https://doi.org/10.1016/j.mcn.2021.103613
Bourgeois-Jaarsma, Q, Miaja Hernandez, P & Groffen, A J 2021, ' Ca 2+ sensor proteins in spontaneous release and synaptic plasticity : Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons ', Molecular and Cellular Neuroscience, vol. 112, 103613 . https://doi.org/10.1016/j.mcn.2021.103613
Bourgeois-Jaarsma, Q, Miaja Hernandez, P & Groffen, A J 2021, ' Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons ', Molecular and Cellular Neuroscience, vol. 112, 103613 . https://doi.org/10.1016/j.mcn.2021.103613
Presynaptic neurotransmitter release is strictly regulated by SNARE proteins, Ca2+ and a number of Ca2+ sensors including synaptotagmins (Syts) and Double C2 domain proteins (Doc2s). More than seventy years after the original description of spontaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f94db41a0cb594c1907cf623536f63
https://doi.org/10.1016/j.mcn.2021.103613
https://doi.org/10.1016/j.mcn.2021.103613
Autor:
Dorthe Labonté, Edda Thies, Yvonne Pechmann, Alexander J Groffen, Matthijs Verhage, August B Smit, Ronald E van Kesteren, Matthias Kneussel
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75603 (2013)
Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport invo
Externí odkaz:
https://doaj.org/article/95750b96611b41399b6c6d7cefd83f91
Publikováno v:
Molecular and cellular neurosciences. 112
Presynaptic neurotransmitter release is strictly regulated by SNARE proteins, Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67b7ef26c63e7f13f4c5fef30c559ec0
https://pubmed.ncbi.nlm.nih.gov/33753311
https://pubmed.ncbi.nlm.nih.gov/33753311
Autor:
Rocío Díez-Arazola, Marieke Meijer, Alexander J. Groffen, Quentin Bourgeois-Jaarsma, L. Niels Cornelisse, Matthijs Verhage
Publikováno v:
Journal of Neuroscience, 40(13), 2606-2617. Society for Neuroscience
Díez-Arazola, R, Meijer, M, Bourgeois-Jaarsma, Q, Niels Cornelisse, L, Verhage, M & Groffen, A J 2020, ' Doc2 proteins are not required for the increased spontaneous release rate in synaptotagmin-1-deficient neurons ', Journal of Neuroscience, vol. 40, no. 13, pp. 2606-2617 . https://doi.org/10.1523/JNEUROSCI.0309-19.2020
J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(13), 2606-2617. Society for Neuroscience
Díez-Arazola, R, Meijer, M, Bourgeois-Jaarsma, Q, Cornelisse, L N, Verhage, M & Groffen, A J 2020, ' Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 40, no. 13, pp. 2606-2617 . https://doi.org/10.1523/JNEUROSCI.0309-19.2020
Díez-Arazola, R, Meijer, M, Bourgeois-Jaarsma, Q, Niels Cornelisse, L, Verhage, M & Groffen, A J 2020, ' Doc2 proteins are not required for the increased spontaneous release rate in synaptotagmin-1-deficient neurons ', Journal of Neuroscience, vol. 40, no. 13, pp. 2606-2617 . https://doi.org/10.1523/JNEUROSCI.0309-19.2020
J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(13), 2606-2617. Society for Neuroscience
Díez-Arazola, R, Meijer, M, Bourgeois-Jaarsma, Q, Cornelisse, L N, Verhage, M & Groffen, A J 2020, ' Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 40, no. 13, pp. 2606-2617 . https://doi.org/10.1523/JNEUROSCI.0309-19.2020
Regulated secretion is controlled by Ca2+sensors with different affinities and subcellular distributions. Inactivation ofSyt1(synaptotagmin-1), the main Ca2+sensor for synchronous neurotransmission in many neurons, enhances asynchronous and spontaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6fac2e415a31bb081cdbdee4f46762
https://research.vumc.nl/en/publications/73139300-be10-4fed-a9cd-7054ccc879ae
https://research.vumc.nl/en/publications/73139300-be10-4fed-a9cd-7054ccc879ae
