Zobrazeno 1 - 10
of 62
pro vyhledávání: '"J Graham Ruby"'
Publikováno v:
eLife, Vol 8 (2019)
For most adult mammals, the risk of death increases exponentially with age, an observation originally described for humans by Benjamin Gompertz. We recently performed a Kaplan–Meier survival analysis of naked mole-rats (Heterocephalus glaber) and c
Externí odkaz:
https://doaj.org/article/4630b5511ea045f5a1f80ca5e7163f5c
Publikováno v:
eLife, Vol 7 (2018)
The longest-lived rodent, the naked mole-rat (Heterocephalus glaber), has a reported maximum lifespan of >30 years and exhibits delayed and/or attenuated age-associated physiological declines. We questioned whether these mouse-sized, eusocial rodents
Externí odkaz:
https://doaj.org/article/0794a511998b47bf9dcdfbf7c6f1a9b2
Autor:
Gilda Grard, Joseph N Fair, Deanna Lee, Elizabeth Slikas, Imke Steffen, Jean-Jacques Muyembe, Taylor Sittler, Narayanan Veeraraghavan, J Graham Ruby, Chunlin Wang, Maria Makuwa, Prime Mulembakani, Robert B Tesh, Jonna Mazet, Anne W Rimoin, Travis Taylor, Bradley S Schneider, Graham Simmons, Eric Delwart, Nathan D Wolfe, Charles Y Chiu, Eric M Leroy
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006583 (2017)
[This corrects the article DOI: 10.1371/journal.ppat.1002924.].
Externí odkaz:
https://doaj.org/article/84452072a2e345b298a1a58d072981f5
Autor:
Gilda Grard, Joseph N Fair, Deanna Lee, Elizabeth Slikas, Imke Steffen, Jean-Jacques Muyembe, Taylor Sittler, Narayanan Veeraraghavan, J Graham Ruby, Chunlin Wang, Maria Makuwa, Prime Mulembakani, Robert B Tesh, Jonna Mazet, Anne W Rimoin, Travis Taylor, Bradley S Schneider, Graham Simmons, Eric Delwart, Nathan D Wolfe, Charles Y Chiu, Eric M Leroy
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005503 (2016)
Externí odkaz:
https://doaj.org/article/2f3f5b8e88664bfea7b5a87766934e22
Autor:
Mark M Slabodnick, J Graham Ruby, Joshua G Dunn, Jessica L Feldman, Joseph L DeRisi, Wallace F Marshall
Publikováno v:
PLoS Biology, Vol 12, Iss 5, p e1001861 (2014)
Morphogenesis and pattern formation are vital processes in any organism, whether unicellular or multicellular. But in contrast to the developmental biology of plants and animals, the principles of morphogenesis and pattern formation in single cells r
Externí odkaz:
https://doaj.org/article/385cce380fc24c29a7d29adc470458ab
Autor:
Gilda Grard, Joseph N Fair, Deanna Lee, Elizabeth Slikas, Imke Steffen, Jean-Jacques Muyembe, Taylor Sittler, Narayanan Veeraraghavan, J Graham Ruby, Chunlin Wang, Maria Makuwa, Prime Mulembakani, Robert B Tesh, Jonna Mazet, Anne W Rimoin, Travis Taylor, Bradley S Schneider, Graham Simmons, Eric Delwart, Nathan D Wolfe, Charles Y Chiu, Eric M Leroy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002924 (2012)
Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in Mangala village, Democratic Republic of Congo (DRC), Africa. The cases, presenting over
Externí odkaz:
https://doaj.org/article/f81b7b1065074d209cd1ab084ec166ac
Autor:
Charles Runckel, Michelle L Flenniken, Juan C Engel, J Graham Ruby, Donald Ganem, Raul Andino, Joseph L DeRisi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20656 (2011)
Honey bees (Apis mellifera) play a critical role in global food production as pollinators of numerous crops. Recently, honey bee populations in the United States, Canada, and Europe have suffered an unexplained increase in annual losses due to a phen
Externí odkaz:
https://doaj.org/article/611f45a5d27b4abb98ebca5415659ef7
Autor:
Katherine Sorber, Charles Chiu, Dale Webster, Michelle Dimon, J Graham Ruby, Armin Hekele, Joseph L DeRisi
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3495 (2008)
High-throughput short-read technologies have revolutionized DNA sequencing by drastically reducing the cost per base of sequencing information. Despite producing gigabases of sequence per run, these technologies still present obstacles in resequencin
Externí odkaz:
https://doaj.org/article/e3af0dfa9d2b4f5587fd53c94401a2bf
Autor:
J Graham Ruby, Andrea Di Francesco, Paulo Ylagan, Angela Luo, Robert Keyser, Owen Williams, Sarah Spock, Wenzhou Li, Nalien Vongtharangsy, Sandip Chatterjee, Cricket A Sloan, Charles Ledogar, Veronica Kuiper, Janessa Kite, Marcelo Cosino, Paulyn Cha, Eleanor M Karlsson
Publikováno v:
The Journals of Gerontology: Series A. 78:762-770
Frailty indexes (FIs) provide quantitative measurements of nonspecific health decline and are particularly useful as longitudinal monitors of morbidity in aging studies. For mouse studies, frailty assessments can be taken noninvasively, but they requ
Publikováno v:
Nature Communications. 14
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and epidemiological etiology of this condition is not well understood. Here, we implemented a machine l