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Preschool-Aged Household Contacts as a Risk Factor for Viral Respiratory Infections in Healthcare Personnel

Autor: Zachary M Most, Ann-Christine Nyquist, Lewis J Radonovich, Maria C Rodriguez-Barradas, Connie Savor Price, Michael S Simberkoff, Mary T Bessesen, Derek A T Cummings, Susan M Rattigan, Charlotte Warren-Gash, Charlotte A Gaydos, Cynthia L Gibert, Geoffrey J Gorse, Trish M Perl

Publikováno v: Open Forum Infectious Diseases. 10

BackgroundViral respiratory infections (VRIs) are common and are occupational risks for healthcare personnel (HCP). VRIs can also be acquired at home and other settings among HCPs. We sought to determine if preschool-aged household contacts are a ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15aab6f73438a6194dc2cc2456df8361
https://doi.org/10.1093/ofid/ofad057

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Outpatient healthcare personnel knowledge and attitudes towards infection prevention measures for protection from respiratory infections

Autor: John Frederick, Mary T. Bessesen, Connie S. Price, Susan M Rattigan, Cynthia L. Gibert, Geoffrey J. Gorse, Trish M. Perl, Michael S. Simberkoff, Charlotte A. Gaydos, Derek A. T. Cummings, Nicholas G. Reich, Alexandria C. Brown, Ann-Christine Nyquist, Maria C. Rodriguez-Barradas, Lewis J. Radonovich

Publikováno v: American Journal of Infection Control. 49:1369-1375

Background Healthcare personnel (HCP) knowledge and attitudes toward infection control measures are important determinants of practices that can protect them from transmission of infectious diseases. Methods Healthcare personnel were recruited from E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a689350f6fd0eee331112801d06decf1
https://doi.org/10.1016/j.ajic.2021.06.011

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Impact of mandatory vaccination of healthcare personnel on rates of influenza and other viral respiratory pathogens

Autor: Trish M. Perl, Alexandria C. Brown, Connie S. Price, Susan M Rattigan, Ann-Christine Nyquist, Mary T. Bessesen, Maria C. Rodriguez-Barradas, Lewis J. Radonovich, Michael S. Simberkoff, Charlotte A. Gaydos, Cynthia L. Gibert, Nicholas G. Reich, Geoffrey J. Gorse, ResPECT Study Team, Derek A. T. Cummings

Publikováno v: Infection Control & Hospital Epidemiology. 43:1216-1220

Objective:The implementation of mandatory influenza vaccination policies among healthcare personnel (HCP) is controversial. Thus, we examined the affect of mandatory influenza vaccination policies among HCP working in outpatient settings.Setting:Four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f51ce160ff3b609cf5eeb2ee143488
https://doi.org/10.1017/ice.2021.324

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A phase 1 dose-sparing, randomized clinical trial of seasonal trivalent inactivated influenza vaccine combined with MAS-1, a novel water-in-oil adjuvant/delivery system

Autor: Geoffrey J. Gorse, Stephen Grimes, Helen Buck, Hussain Mulla, Peter White, Heather Hill, Jeanine May, Sharon E. Frey, Peter Blackburn

Publikováno v: Vaccine. 40(9)

New influenza vaccines are needed to increase vaccine efficacy. Adjuvants may allow hemagglutinin (HA) dose-sparing with enhanced immunogenicity. MAS-1 is an investigational low viscosity, free-flowing, water-in-oil emulsion-based adjuvant/delivery s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a425d1e3633b52070997741141cee2
https://pubmed.ncbi.nlm.nih.gov/35125219

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MAS-1, a novel water-in-oil adjuvant/delivery system, with reduced seasonal influenza vaccine hemagglutinin dose may enhance potency, durability and cross-reactivity of antibody responses in the elderly

Autor: Geoffrey J. Gorse, Stephen Grimes, Helen Buck, Hussain Mulla, Peter White, Heather Hill, Jeanine May, Sharon E. Frey, Peter Blackburn

Publikováno v: Vaccine. 40(10)

Increased influenza vaccine efficacy is needed in the elderly at high-risk for morbidity and mortality due to influenza infection. Adjuvants may allow hemagglutinin (HA) dose-sparing with enhanced immunogenicity. MAS-1 is an investigational water-in-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6c361d7488c4d3972fb175b8a38100
https://pubmed.ncbi.nlm.nih.gov/35125224

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Influence of Preseason Antibodies Against Influenza Virus on Risk of Influenza Infection Among Healthcare Personnel

Autor: Connie S. Price, Maria C. Rodriguez-Barradas, Mary T. Bessesen, Susan M Rattigan, Trish M. Perl, Geoffrey J. Gorse, Cynthia L. Gibert, Lewis J. Radonovich, Alexander Kirpich, Derek A. T. Cummings, Michael S. Simberkoff, Charlotte A. Gaydos, Ann-Christine Nyquist

Publikováno v: The Journal of infectious diseases. 225(5)

Background The association of hemagglutination inhibition (HAI) antibodies with protection from influenza among healthcare personnel (HCP) with occupational exposure to influenza viruses has not been well-described. Methods The Respiratory Protection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673af724ae9a091e14b79d9ffb6fcdc7
https://pubmed.ncbi.nlm.nih.gov/34534319

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Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial

Autor: Geoffrey J. Gorse, Derek A. T. Cummings, Maria C. Rodriguez-Barradas, Lewis J. Radonovich, Trish M. Perl, Mary T. Bessesen, Cynthia L. Gibert, Jenna Los, Alexandria C. Brown, Jacquelyn Lykken, Michael S. Simberkoff, Charlotte A. Gaydos, Connie S. Price, Susan M Rattigan, Ann-Christine Nyquist, Nicholas G. Reich

Publikováno v: American Journal of Infection Control

Background Health care personnel (HCP) working in outpatient settings routinely interact with patients with acute respiratory illnesses. Absenteeism following symptom development and lack of staff trained to obtain samples limit efforts to identify p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6046d7194f8285cc05e104ee148b41
https://pubmed.ncbi.nlm.nih.gov/33581146

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Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus‐associated illnesses

Autor: Gira B. Patel, Mary M. Donovan, Geoffrey J. Gorse

Publikováno v: Journal of Medical Virology

Human coronaviruses (HCoV) are common causes of respiratory illnesses (RI) despite preexisting humoral immunity. Sera were obtained near the onset of RI and 3 to 4 weeks later as part of a prospective study of 200 subjects evaluated for RI from 2009

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Interpatient mutational spectrum of human coronavirus‐OC43 revealed by illumina sequencing

Autor: Gira B. Patel, Geoffrey J. Gorse, Xiaofeng Fan

Publikováno v: Journal of Medical Virology

Human coronaviruses (HCoV) are RNA viruses that cause respiratory tract infections with viral replication of limited duration. The host and viral population heterogeneity could influence clinical phenotypes. Employing long RT-PCR with Illumina sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bdf53aa8476de9beb6ce7b47a07d4e
http://europepmc.org/articles/PMC7166611

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