Zobrazeno 1 - 10
of 1 553
pro vyhledávání: '"J Glynn"'
Autor:
Sudha R. Raman, Bradley G. Hammill, Pamela A. Shaw, Hana Lee, Sengwee Toh, John G. Connolly, Kimberly J. Dandreo, Vinit Nalawade, Fang Tian, Wei Liu, Jie Li, José J. Hernández-Muñoz, Robert J. Glynn, Rishi J. Desai, Janick Weberpals
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Missing data in confounding variables present a frequent challenge in generating evidence using real-world data, including electronic health records (EHR). Our objective was to apply a recently published toolkit for characterizing
Externí odkaz:
https://doaj.org/article/4ae0b29ad6134def83c0064c37302018
Autor:
Katherine P. Liao, Pamela Rist, Jon Giles, Leah Santacroce, Margery A. Connelly, Robert J. Glynn, Paul Ridker, Ahmed Tawakol, Joan Bathon, Daniel H. Solomon
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)
Abstract Background Treatments for rheumatoid arthritis (RA) are associated with complex changes in lipids and lipoproteins that may impact cardiovascular (CV) risk. The objective of this study was to examine lipid and lipoprotein changes associated
Externí odkaz:
https://doaj.org/article/1c5c699bc81445dabdab7e0cb72982ed
Autor:
Darae Ko, Peter T. Evans, Kueiyu Joshua Lin, Ashvin N. Pande, Alexander Cervone, Su Been Lee, Susan Cheng, Theodore Tsacogianis, Robert J. Glynn, Dae Hyun Kim
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)
Background Ticagrelor is recommended over clopidogrel in acute coronary syndrome based on the results of the PLATO (Study of Platelet Inhibition and Patient Outcomes) trial. We aimed to emulate PLATO in older adults with and without frailty and with
Externí odkaz:
https://doaj.org/article/566180384cb643828b21308205d89c7b
Autor:
Phyo T. Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J. Wexler, Brendan M. Everett, Robert J. Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M. Paik, Elisabetta Patorno
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background No randomized clinical trials have directly compared the cardiorenal effectiveness of empagliflozin and GLP-1RA agents with demonstrated cardioprotective effects in patients with a broad spectrum of cardiovascular risk. We reporte
Externí odkaz:
https://doaj.org/article/a409dae7b8d64bffbc67fb3a8cee406b
Autor:
Phyo T. Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J. Wexler, Brendan M. Everett, Robert J. Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M. Paik, Elisabetta Patorno
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/1b45064e466d4e25abc84ea3e931b788
Publikováno v:
Stats, Vol 6, Iss 2, Pp 526-538 (2023)
The area under the true ROC curve (AUC) is routinely used to determine how strongly a given model discriminates between the levels of a binary outcome. Standard inference with the AUC requires that outcomes be independent of each other. To overcome t
Externí odkaz:
https://doaj.org/article/7338caba236443578d45b77b8db4e646
Autor:
Daniel H Solomon, Robert J Glynn, Niteesh K Choudhry, Julie C Lauffenburger, Elliott M Antman, Su Been Lee, Helen Tesfaye, Angela Tong
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objective Poor medication adherence remains highly prevalent and adversely affects health outcomes. Patients frequently describe properties of the pills themselves, like size and shape, as barriers, but this has not been evaluated objectively. We sou
Externí odkaz:
https://doaj.org/article/ea3708e7ec0d49e3ab4121ede648a5bc
Publikováno v:
Geoscientific Model Development, Vol 15, Pp 4991-5019 (2022)
Ireland has significantly increased its climate mitigation ambition, with a recent government commitment to reduce greenhouse gases by an average of 7 % yr−1 in the period to 2030 and a net-zero target for 2050, underpinned by a series of 5-year ca
Externí odkaz:
https://doaj.org/article/6f3a218ba93640609e4310da700b1623
Autor:
Robert J Glynn, Niteesh K Choudhry, Julie C Lauffenburger, Lorenzo Trippa, Massimiliano Russo, Steffen Ventz
Publikováno v:
BMJ Medicine, Vol 1, Iss 1 (2022)
Randomised controlled clinical trials are widely considered the preferred method for evaluating the efficacy or effectiveness of interventions in healthcare. Adaptive trials incorporate changes as the study proceeds, such as modifying allocation prob
Externí odkaz:
https://doaj.org/article/5065934ba47f4160b4ae430c31ec5f7a
Autor:
Jon T. Giles, Pamela M. Rist, Katherine P. Liao, Ahmed Tawakol, Zahi A. Fayad, Venkatesh Mani, Nina P. Paynter, Paul M. Ridker, Robert J. Glynn, Fengxin Lu, Rachel Broderick, Meredith Murray, Kathleen M. M. Vanni, Daniel H. Solomon, Joan M. Bathon
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 6, Pp 371-380 (2021)
Individuals with rheumatoid arthritis (RA) are at increased risk for atherosclerotic cardiovascular disease (ASCVD) events relative to the general population, potentially mediated by atherosclerotic plaques that are more inflamed and rupture prone. W
Externí odkaz:
https://doaj.org/article/e842df4b45cc4bd49735e4e8887b967e