Zobrazeno 1 - 10
of 416
pro vyhledávání: '"J Geldenhuys"'
Autor:
Jamie L. McCall, Werner J. Geldenhuys, Lisa J. Robinson, Michelle R. Witt, Peter M. Gannett, Björn C. G. Söderberg, Harry C. Blair, Jonathan Soboloff, John B. Barnett
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract This study provides a detailed understanding of the preclinical pharmacokinetics and metabolism of ELP‐004, an osteoclast inhibitor in development for the treatment of bone erosion. Current treatments for arthritis, including biological di
Externí odkaz:
https://doaj.org/article/14ba5e5d547b4005a0abb7a8ff4e9e70
Autor:
Krystal A. Hughes, Bishal Misra, Maryam Maghareh, Parinya Samart, Ethan Nguyen, Salik Hussain, Werner J. Geldenhuys, Sharan Bobbala
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often formulated through single- or double-emulsion methods utilizing pol
Externí odkaz:
https://doaj.org/article/a037d4eacb90426fa21e8cf7ab145a4a
Autor:
Eméline S. P. Assèdé, S. S. Honoré Biaou, Hidirou Orou, Madjidou Oumorou, Coert J. Geldenhuys, Paxie W. Chirwa, Brice Sinsin
Publikováno v:
Vegetation Classification and Survey (VCS), Vol 4, Iss , Pp 139-165 (2023)
Aims: This study aims to: i) differentiate the plant associations in the Biosphere Reserve of Pendjari (BRP), ii) determine the ecological characteristics of their habitats and iii) present distribution maps on different soil types. Study area: The B
Externí odkaz:
https://doaj.org/article/e6f6c6c40e3443c992b42e1344ca3653
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The interphotoreceptor matrix (IPM) is a specialized extracellular mesh of molecules surrounding the inner and outer segments of photoreceptor neurons. Interphotoreceptor matrix proteoglycan 1 and 2 (IMPG1 and IMPG2) are major components of
Externí odkaz:
https://doaj.org/article/da8e82f0559440b1ae306a0c99462261
Autor:
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102636- (2023)
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); howev
Externí odkaz:
https://doaj.org/article/fc1d13f5ed7a4f76bf1f12017427f9c4
Autor:
David A. Stanton, Hannah E. Wilson, Matthew G. Chapa, Jessica N. Link, Kristin Lupinacci, Werner J. Geldenhuys, Emidio E. Pistilli
Publikováno v:
JCSM Rapid Communications, Vol 5, Iss 2, Pp 239-253 (2022)
Abstract Background Fatigue is common in patents with breast cancer (BC), and can occur in patients with early stage disease and in the absence of muscle wasting (i.e. cachexia). We have reported transcriptional and proteomic alterations in muscles f
Externí odkaz:
https://doaj.org/article/1e125db33c104bd48e7c90f76b5522d3
Autor:
Jacob R. Boos, Hanna N. Jandrain, Emi Hagiuda, Alexander T. Taguchi, Kazuya Hasegawa, Bailey L. Fedun, Sarah J. Taylor, Sofhia M. Elad, Sarah E. Faber, Takashi Kumasaka, Toshio Iwasaki, Werner J. Geldenhuys
Publikováno v:
Advances in Redox Research, Vol 6, Iss , Pp 100048- (2022)
CISD-1/mitoNEET is an evolutionarily conserved outer mitochondrial membrane [2Fe-2S] protein that regulates mitochondrial function and morphology. The [2Fe-2S] clusters are redox reactive and shown to mediate oxidative stress in vitro and in vivo. Ho
Externí odkaz:
https://doaj.org/article/63ce18420c8049339dc30f096fa06230
Autor:
Stephanie L. Rellick, Gangqing Hu, Debra Piktel, Karen H. Martin, Werner J. Geldenhuys, Rajesh R. Nair, Laura F. Gibson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract B-cell acute lymphoblastic leukemia (ALL) is characterized by accumulation of immature hematopoietic cells in the bone marrow, a well-established sanctuary site for leukemic cell survival during treatment. While standard of care treatment re
Externí odkaz:
https://doaj.org/article/02e67ef2e47e4759ada75b05f17cb760
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/743aafd69bdb4413bb3d46aa65f08594
Publikováno v:
ACS Omega, Vol 5, Iss 39, Pp 25113-25124 (2020)
Externí odkaz:
https://doaj.org/article/ac08e3eed9104aecb98ebf23b124118b