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Akademický článek

Relationship between apolipoprotein E mRNA expression and tissue cholesterol content in rat adrenal gland.

Autor: MM Prack, M Nicosia, DL Williams, J Gwynne

Publikováno v: Journal of Lipid Research, Vol 32, Iss 10, Pp 1611-1618 (1991)

Among extrahepatic tissues the adrenal gland has one of the highest concentrations of apoE mRNA and the highest rate of apoE synthesis. In the present investigation several previously described in vivo treatments were used to assess the relationship

Externí odkaz: https://doaj.org/article/934359a313f140b4886475f4d5c7cea7

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Akademický článek

Metabolic modeling predicts unique drug targets in Borrelia burgdorferi

Autor: Peter J. Gwynne, Kee-Lee K. Stocks, Elysse S. Karozichian, Aarya Pandit, Linden T. Hu

Publikováno v: mSystems, Vol 8, Iss 6 (2023)

ABSTRACT The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent, with a small genome and correspondingly limited metabolism. As such, it is an excellent candidate for the development of targeted, narrow-spectrum antimicrobials. T

Externí odkaz: https://doaj.org/article/8c56f19eefd9463f8ea4cbaf186513ca

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Akademický článek

Light as a Broad-Spectrum Antimicrobial

Autor: Peter J. Gwynne, Maurice P. Gallagher

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Antimicrobial resistance is a significant and growing concern. To continue to treat even simple infections, there is a pressing need for new alternative and complementary approaches to antimicrobial therapy. One possible addition to the current range

Externí odkaz: https://doaj.org/article/dfc0f7c50fad419bb191bc0f701f2cdb

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Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi

Autor: Peter J. Gwynne, Luke H. Clendenen, Siu-Ping Turk, Adriana R. Marques, Linden T. Hu

Publikováno v: Journal of Clinical Investigation. 132

A close association with its vertebrate and tick hosts allows Borrelia burgdorferi, the bacterium responsible for Lyme disease, to eliminate many metabolic pathways and instead scavenge key nutrients from the host. A lipid-defined culture medium was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca9882135099b0ddbccde8ecd91b383
https://doi.org/10.1172/jci152506

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Evaluation of Staphylococcus aureus eradication therapy in orthopaedic surgery

Autor: Steff Lewis, Kate Templeton, Timothy S. Walsh, Peter J. Gwynne, S.T.J. Tsang, A. H. R. W. Simpson, Martin P McHugh, Daniel Guerendiain, I. F. Laurenson, Julia Boyd

Publikováno v: Tsang, J, McHugh, M, Guerendiain, D, Gwynne, P, Lewis, S, Laurenson, I F, Templeton, K, Simpson, H & Walsh, T 2018, ' Evaluation of Staphylococcus aureus eradication therapy in orthopaedic surgery ', Journal of Medical Microbiology . https://doi.org/10.1099/jmm.0.000731

Purpose. Despite WHO recommendations there is currently no national screening and eradication policy for the detection of methicillin-sensitive Staphylococcus aureus (MSSA) in the UK prior to elective orthopaedic surgery. This study aimed to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae28fedae5d2d993e566822d119fe3ac
https://doi.org/10.1099/jmm.0.000731

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Unexpected synergistic and antagonistic antibiotic activity against Staphylococcus biofilms

Autor: S P MacKenzie, Peter J. Gwynne, A. H. R. W. Simpson, Maurice P. Gallagher, G. F. Dall, S.T.J. Tsang, Steffen J. Breusch

Publikováno v: Dall, G F, Tsang, J, Gwynne, P, MacKenzie, S, Simpson, H, Breusch, S & Gallagher, M 2018, ' Unexpected synergistic and antagonistic antibiotic activity against Staphylococcus biofilms ', Journal of Antimicrobial Chemotherapy, vol. 73, no. 7, pp. 1830–1840 . https://doi.org/10.1093/jac/dky087

ObjectivesTo evaluate putative anti-staphylococcal biofilm antibiotic combinations used in the management of periprosthetic joint infections (PJIs).MethodsUsing the dissolvable bead biofilm assay, the minimum biofilm eradication concentration (MBEC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d9ece413341fb662ed39094314baa1
https://doi.org/10.1093/jac/dky087

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Benefits of Applications of Chlorothalonil for the Control of Black Mold of Tomato

Autor: B. J. Gwynne, R. M. Davis, J.G. Valencia, Mullen R, D. M. May, E.M. Miyao

Publikováno v: Plant disease. 81(6)

Chlorothalonil was applied 2, 4, 6, 2 and 4, or 4 and 6 weeks prior to tomato harvest in fields in four counties in California over a 3-year period to assess the economic benefits of chlorothalonil applications, if any, on the reduction of black mold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1224712151ab12381bcd9837f1c545
https://pubmed.ncbi.nlm.nih.gov/30861842

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The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection

Autor: A. H. R. W. Simpson, Maurice P. Gallagher, Peter J. Gwynne, S.T.J. Tsang

Publikováno v: Bonejoint research. 7(8)

Objectives Periprosthetic joint infection following joint arthroplasty surgery is one of the most feared complications. The key to successful revision surgery for periprosthetic joint infections, regardless of treatment strategy, is a thorough deep d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97069f20c376089a036b54e2f07df3f
https://pubmed.ncbi.nlm.nih.gov/30258571

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Underestimation of Staphylococcus aureus (MRSA and MSSA) carriage associated with standard culturing techniques : One third of carriers missed

Autor: Daniel Guerendiain, Timothy S. Walsh, Peter J. Gwynne, Martin P McHugh, I. F. Laurenson, Shao-Ting Jerry Tsang, A. H. R. W. Simpson, Julia Boyd, Kate Templeton

Publikováno v: Bone & Joint Research
Tsang, J, McHugh, M, Guerendiain, D, Gwynne, P, Boyd, J, Simpson, H, Walsh, T, Laurenson, I F & Templeton, K 2018, ' Underestimation of Staphylococcus aureus (MRSA and MSSA) carriage associated with standard culturing techniques: one third of carriers missed. ', Bone & Joint Research . https://doi.org/10.1302/2046-3758.71.BJR-2017-0175.R1

Objectives Nasal carriers of Staphylococcus (S.) aureus (MRSA and MSSA) have an increased risk for healthcare-associated infections. There are currently limited national screening policies for the detection of S. aureus despite the World Health Organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466516bde8d2460ebb2e220c133b8c49
https://hdl.handle.net/10023/20608

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The dissolvable bead: A novel in vitro biofilm model for evaluating antimicrobial resistance

Autor: S.T.J. Tsang, Steffen J. Breusch, Peter J. Gwynne, G. F. Dall, A. H. R. W. Simpson, A.J. Wilkinson, Maurice P. Gallagher

Publikováno v: Dall, G F, Tsang, J, Gwynne, P J, Wilkinson, A J, Simpson, A H R W, Breusch, S J B & Gallagher, M P 2017, ' The dissolvable bead : A novel in vitro biofilm model for evaluating antimicrobial resistance ', Journal of microbiological methods . https://doi.org/10.1016/j.mimet.2017.08.020

In vitro biofilm assays are a vital first step in the assessment of therapeutic effectiveness. Current biofilm models have been found to be limited by throughput, reproducibility, and cost. We present a novel in vitro biofilm model, utilising a sodiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304b294703e8faba27f647efb652cdf
https://pubmed.ncbi.nlm.nih.gov/28870772

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