Zobrazeno 1 - 10
of 71
pro vyhledávání: '"J G van de Winkel"'
Autor:
I A Heijnen, L J Rijks, A Schiel, B Stockmeyer, H H van Ojik, M Dechant, T Valerius, T Keler, A L Tutt, M J Glennie, E A van Royen, P J Capel, J G van de Winkel
Publikováno v:
The Journal of Immunology. 159:5629-5639
Abs are able to induce inflammatory antitumor responses by recruiting IgG Fc receptor (FcgammaR)-bearing cytotoxic effector cells. We recently described the capacity of the high affinity FcgammaRI (CD64) to trigger cytotoxic activity of neutrophils (
Publikováno v:
The Journal of Immunology. 157:5660-5665
Previous studies have suggested that complement receptors cooperate with Fc receptors to mediate Ab-dependent effector functions. In the present study, we tested the capacity of complement receptor type 3 (CR3; alphaM beta2; CD11b/CD18) to participat
Publikováno v:
The Journal of Immunology. 154:2896-2903
Four individuals have been identified, within a single family, who lack phagocyte expression of the high affinity type I IgG receptor (CD64). As a result, their monocytes are unable to support mouse IgG2a anti-CD3-induced T cell mitogenesis (nonrespo
Publikováno v:
The Journal of Immunology. 154:1852-1860
Rat mAbs receive considerable interest for immunologic intervention in man. The rat IgG2b isotype has previously been found to be optimally active both in vivo and in vitro. We found that both a rat IgG2b CD3 mAb and a monovalent hybrid rat IgG2b-mou
Publikováno v:
The Journal of Immunology. 152:574-585
The low affinity IgG receptor Fc gamma RII (CD32) represents the most widely distributed class of human Fc gamma R. To analyze the biologic functions of different Fc gamma RII isoforms, we stably transfected Fc gamma RIIb1, IIb1*, IIb2, IIa, and a II
Autor:
R G Bredius, C E de Vries, A Troelstra, L van Alphen, R S Weening, J G van de Winkel, T A Out
Publikováno v:
The Journal of Immunology. 151:1463-1472
To assess the function of IgG subclass antibodies we studied the opsonization of Staphylococcus aureus (STAW) and Haemophilus influenzae type b (Hib) by natural IgG1 and IgG2 antibodies from five healthy individuals. Phagocytosis by polymorphonuclear
Publikováno v:
Blood. 81:2413-2419
Eosinophils are important in antibody-mediated immune defense against parasites based on interaction with Ig receptors (FcR). Of the three classes of IgG FcR in humans, hFc gamma RI, II, and III, solely hFc gamma RII (CD32) is expressed on freshly is
Publikováno v:
The Journal of Immunology. 150:3030-3041
We have tested the possible physical interactions between the iC3b receptor (CR3), lymphocyte function-associated Ag-1, and class III Fc gamma receptor (Fc gamma RIII) at neutrophil surfaces. Cells were labeled using fluorochrome-conjugated Fab or F(
Publikováno v:
Blood. 79:1651-1656
Multiple isoforms of human (h) Fc gamma RII are currently recognized. We set up experiments to evaluate the significance of different hFc gamma RII (CD32) isoforms in the uptake of IgG-coated particles. Therefore, a panel of stable hFc gamma RII-tran
Publikováno v:
The Journal of Immunology. 148:695-701
T cell activation induced by mouse anti-CD3 mAb has shown to be dependent on the Ig isotype of these antibodies. A study of isotype dependency of human antibodies, however, seems more relevant to human effector systems, especially in view of the avai