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CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used

Autor: R E Callard, K P Rigley, S H Smith, S Thurstan, J G Shields

Publikováno v: The Journal of Immunology. 148:2983-2987

The regulation of human B cell proliferation and differentiation by the CD19 surface glycoprotein was investigated. As expected, proliferation induced by costimulation with anti-IgM plus IL-4 or IL-2, or with G28.8 antibody plus IL-4 was inhibited by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf064746c18c389365e43bc8f91cd22
https://doi.org/10.4049/jimmunol.148.10.2983

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Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein

Autor: L M, Higgins, S A, McDonald, N, Whittle, N, Crockett, J G, Shields, T T, MacDonald

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(1)

OX40 is a member of the TNFR superfamily, and is found predominantly on activated CD4-positive T cells. In vitro an OX40-IgG fusion protein inhibits mitogen- and Ag-driven proliferation and cytokine release by splenocytes and lymph node T cells. In c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f6f2af23c3a85826223674e049e62c6
https://pubmed.ncbi.nlm.nih.gov/9886424

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Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus as a Vector for Immunotherapy of Cancer

Autor: Claire Entwisle, Shiva Sivasubramaniam, Cornelia S. McLean, Robert C. Rees, D. M. Blakeley, SC Hill, Selman A. Ali, J. Miller, Stephen Charles Inglis, Michael Edward Griff Boursnell, Stephen Reeder, J. G. Shields

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461374442

Although the idea of immunotherapy for cancer is not new, recent advances in gene delivery systems and the discovery of new immunomodulatory genes has meant that the field is currently extremely active [1]. The delivery of genes which can modify the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c033e0ac60821e42fd61e0fee3272ad0
https://doi.org/10.1007/978-1-4615-5357-1_59

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CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used

Autor: R E, Callard, K P, Rigley, S H, Smith, S, Thurstan, J G, Shields

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 148(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::858544f896fb14bfade25fe36cf64c38
https://pubmed.ncbi.nlm.nih.gov/1374445

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Epstein-Barr-virus-transformed lymphoblastoid cell lines derived from patients with X-linked agammaglobulinaemia and Wiskott-Aldrich syndrome: responses to B cell growth and differentiation factors

Autor: Y L, Lau, J G, Shields, R J, Levinsky, R E, Callard

Publikováno v: Clinical and experimental immunology. 75(2)

Epstein-Barr-virus-transformed B lymphoblastoid cell lines (EBV-transformed LCL) from three patients with X-linked agammaglobulinaemia (XLA), six patients with Wiskott-Aldrich Syndrome (WAS), and seven normal donors, were tested for growth and differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dab478466ad113479e874b3b9c2aaf33
https://pubmed.ncbi.nlm.nih.gov/2539277

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Intestinal hypersensitivity reactions in the rat. I. Uptake of intact protein, permeability to sugars and their correlation with mucosal mast-cell activation

Autor: M W, Turner, P, Boulton, J G, Shields, S, Strobel, S, Gibson, H R, Miller, R J, Levinsky

Publikováno v: Immunology. 63(1)

We have confirmed previous observations that intestinal anaphylaxis induced in rats previously sensitized to ovalbumin (OVA) is associated with an increased uptake of an unrelated 'bystander' protein, bovine serum albumin (BSA) fed 1 hr previously. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::733e0f066ff323f90820f42fd262a8d8
https://pubmed.ncbi.nlm.nih.gov/3422220

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