Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Autor: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Cécile T. J. Holweg, Åsa M. Wheelock, Barbro Dahlén, Björn Nordlund, Kjell Alving, Gunilla Hedlin, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Sven-Erik Dahlén, Craig E. Wheelock, H. Ahmed, C. Auffray, A. T. Bansal, E. H. Bel, J. Bigler, B. Billing, F. Baribaud, H. Bisgaard, M. J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, A. Chaiboonchoe, C. H. Compton, J. Corfield, D. Cunoosamy, A. D’Amico, B. De Meulder, V. J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L. J. Fleming, E. Formaggio, U. Frey, M. Gahlemann, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, P. W. Hekking, T. Higenbottam, J. M. Hohlfeld, A. J. Knox, N. Lazarinis, D. Lefaudeux, M. J. Loza, R. Lutter, A. Manta, S. Masefield, J. G. Matthews, A. Mazein, A. Meiser, R. J. M. Middelveld, M. Miralpeix, N. Mores, C. S. Murray, J. Musial, D. Myles, L. Pahus, S. Pavlidis, A. Postle, P. Powel, G. Praticò, M. PuigValls, N. Rao, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J. P. R. Schofield, W. Seibold, A. Selby, R. Sigmund, F. Singer, P. J. Skipp, M. Smicker, K. Sun, B. Thornton, M. Uddin, W. M. van Aalderen, M. van Geest, J. Vestbo, N. H. Vissing, A. H. Wagener, S. S. Wagers, Z. Weiszhart, S. J. Wilson, J. Östling

Publikováno v: U-BIOPRED Study Group 2020, ' Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study. ', American Journal of Respiratory and Critical Care Medicine, vol. 203, no. 1, pp. 37-53 . https://doi.org/10.1164/rccm.201909-1869OC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2021, 203 (1), pp.37-53. ⟨10.1164/rccm.201909-1869OC⟩

Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e52ab64017bba43414900205d8dbd0
https://doi.org/10.1164/rccm.201909-1869OC

High tibial osteotomy without internal fixation for medial unicompartmental osteoarthrosis

Autor: J G Matthews, Muhammad Tahir Khan

Publikováno v: Orthopedics. 23(10)

Between 1982 and 1993, a total of 35 patients underwent high tibial osteotomy for medial unicompartmental osteoarthrosis. The osteotomy was performed high in the tibia without the use of jigs, and internal fixation devices were avoided. Patients were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e5168a2628da70171ce2c8d6b09ebc
https://pubmed.ncbi.nlm.nih.gov/11045550

The Anglo-Saxon Library (review)

Autor: J. G. Matthews

Publikováno v: Libraries & the Cultural Record. 43:109-110

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4abb5db8e36c1859c40af3e8497e1bf6
https://doi.org/10.1353/lac.2008.0004

Pneumonia in patients with multiple trauma

Autor: D I, McRitchie, J G, Matthews, M P, Fink

Publikováno v: Clinics in chest medicine. 16(1)

This article examines the features of nosocomial pneumonia in the subpopulation of patients with multiple trauma. Epidemiology, trauma-associated risk factors, diagnosis, microbiology, therapy, and prevention are reviewed. While some issues may overl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e0e8bc429715232044b7c7248f0453b
https://pubmed.ncbi.nlm.nih.gov/7768087

Improving care: a study of orthopaedic outpatient referrals

Autor: G W Simonds, Martin Roland, B Bewley, R W Porter, J G Matthews, J F Redden

OBJECTIVE--To identify aspects of outpatient referral in which general practitioners9, consultants9, and patients9 satisfaction could be improved. DESIGN--Questionnaire survey of general practitioners, consultant orthopaedic surgeons, and patients re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08af8cc16cf2c1c28e366c7d89aef01e
https://europepmc.org/articles/PMC1669808/