Zobrazeno 1 - 10
of 46
pro vyhledávání: '"J G Kenna"'
The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 8:909-920
HepaRG is a unique cell line showing a great plasticity, which differentiates to both canaliculae-like and hepatocyte-like cells. The long-term stability of key cell functions, for example, the drug-metabolizing cytochrome P450 (CYP) enzyme activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f2959e5dca8619cf3b6266df02ffdc
https://doi.org/10.1517/17425255.2012.685159
https://doi.org/10.1517/17425255.2012.685159
Autor:
S Stone, Rebecca J. Dearman, Ian Kimber, Helen Theresa Caddick, J. G. Kenna, David A. Basketter
Publikováno v:
Food and Chemical Toxicology. 40:625-633
The ability of food proteins to resist digestion in simulated gastric fluid (SGF) correlates with allergenic potential. The purpose of the current investigations was to determine whether this association is due solely to the failure of unstable prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44a05b3f77f25c26cf29fbb4c79ff56
https://doi.org/10.1016/s0278-6915(01)00132-6
https://doi.org/10.1016/s0278-6915(01)00132-6
Publikováno v:
Toxicology. 147:147-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e3e9a7a936efe37232525b1bdbca6b
https://doi.org/10.1016/s0300-483x(00)00225-0
https://doi.org/10.1016/s0300-483x(00)00225-0
Publikováno v:
Anaesthesia. 53:905-909
This report is of a case of a previously fit 65-year-old woman who developed postoperative liver dysfunction following an anaesthetic involving isoflurane. Biliary ultrasound demonstrated gallstones. However, serum antibodies to trifluoroacetylated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620f06baeb9e4d9f91ced79f22248476
https://doi.org/10.1046/j.1365-2044.1998.00567.x
https://doi.org/10.1046/j.1365-2044.1998.00567.x
Publikováno v:
Carcinogenesis. 18:1775-1783
Cytochrome P450 mediated metabolism of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol has been investigated in vitro. Kinetic studies undertaken in liver microsomes from control male Fischer 344 rats revealed that this reaction is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9375126abc79ac8f51f7e4952860b1
https://doi.org/10.1093/carcin/18.9.1775
https://doi.org/10.1093/carcin/18.9.1775
Publikováno v:
Anaesthesia. 51:622-626
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78407cb8586ad7bec02a67b4aa36d95c
https://doi.org/10.1111/j.1365-2044.1996.tb04642.x
https://doi.org/10.1111/j.1365-2044.1996.tb04642.x
Publikováno v:
Chemical Research in Toxicology. 9:713-721
Methyleugenol is an allylbenzene food flavoring which has been shown to form DNA and protein adducts, and to cause hepatotoxicity and carcinogenicity in rodents. In order to investigate the nature of the protein adducts, specific antisera were raised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acc22f3c3d7095c139c7837ca7b76cd
https://doi.org/10.1021/tx950211v
https://doi.org/10.1021/tx950211v
Autor:
J G Kenna, Ronald M. Jones
Publikováno v:
Anesthesia & Analgesia. 81:51S-66S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6bbbc9c611aee1585b1b253793f5f3
https://doi.org/10.1097/00000539-199512001-00008
https://doi.org/10.1097/00000539-199512001-00008
Autor:
John Koskinas, P. L. Weissberg, Peter J. Richardson, A Harcombe, J G Kenna, L. Ramsay, H. J. F. Why, GraemeJ.M. Alexander
Publikováno v:
Clinical Science. 88:263-268
1. Serum samples from patients with alcoholic heart muscle disease and from control subjects with and without heart disease who did not drink to excess were screened by Western immunoblotting for antibodies to acetaldehyde-modified cardiac cytosolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a7ef41d52bd572137e2c6351ab417c
https://doi.org/10.1042/cs0880263
https://doi.org/10.1042/cs0880263
Publikováno v:
Toxicology in Vitro. 7:311-315
Previous investigations have implicated an immune response to trifluoroacetylated proteins (TFA-proteins) in the pathogenesis of halothane hepatitis. The objective of this study was to establish conditions for generation of TFA-proteins in hepatocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67189585d6e5322b478219ac9f3d7b92
https://doi.org/10.1016/0887-2333(93)90020-6
https://doi.org/10.1016/0887-2333(93)90020-6