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Association between plasma desmosine, a marker of elastin degradation, and total atherosclerotic burden measured by whole body magnetic resonance angiography

Autor: K Ali, J R Weir-Mccall, F Khan, J Belch, J G Houston, I R Mordi, C C Lang, J T J Huang, A M Choy

Publikováno v: European Heart Journal. 43

Background Elastin degradation has been implicated in the pathophysiology of vulnerable atherosclerotic plaque. Desmosine is the cross-link component in the elastin molecule and is exclusively released from mature elastin breakdown, thus has the pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::668f33da23e2f09a13387ed21a20c715
https://doi.org/10.1093/eurheartj/ehac544.2934

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Suspected malignant cord compression – improving time to diagnosis via a ‘hotline’: a prospective audit

Autor: Lee Baker, J G Houston, John Dewar, Pamela Levack, S Eljamel, Trudy McLeay, Alastair J. Munro, Robert M. Grant, Lynsay Allan

Publikováno v: British Journal of Cancer

The aim of the study was to achieve earlier diagnosis of malignant cord compression (MCC) using urgent magnetic resonance imaging (MRI) for selected patients. A comparison was carried out of the current prospective audit of 100 patients referred by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0872f653d212234bfb16844d8a497329
https://doi.org/10.1038/sj.bjc.6605079

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Ethnomedicinally selected plants as sources of potential analgesic compounds: indication ofin vitro biological activity in receptor binding assays

Autor: J. D. Phillipson, M. J. O’Neill, J. A. Lewis, John H. Sampson, N. G. Bowery, J. G. Houston

Publikováno v: Phytotherapy Research. 14:24-29

A number of plant species used in traditional medicine for the relief of pain have been selected from the medicinal and scientific literature of China, South America, Asia and West Africa. Extracts were prepared and tested in three in vitro receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f1f7f028a75bab2122ddf1568c834d7
https://doi.org/10.1002/(sici)1099-1573(200002)14:1<24::aid-ptr537>3.0.co

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The Squalestatins: Novel Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in vivo Evaluation of C1-Modified Analogs

Autor: P A, Procopiou, E J, Bailey, M J, Bamford, A P, Craven, B W, Dymock, J G, Houston, J L, Hutson, B E, Kirk, A D, McCarthy, M, Sareen

Publikováno v: Journal of Medicinal Chemistry. 37:3274-3281

Squalestatin analogues modified in the C1 side chain were prepared and evaluated for their ability to inhibit rat liver microsomal and Candida squalene synthase (SQS) in vitro. While maintaining the 4,6-dimethyloctenoate or 4,6-dimethyloctanoate este

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff321dc4c4e3be2a2b2e341edc448e6a
https://doi.org/10.1021/jm00046a011

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