Metabolomic profiling of microbial disease etiology in community-acquired pneumonia.

Autor: Ilona den Hartog, Laura B Zwep, Stefan M T Vestjens, Amy C Harms, G Paul Voorn, Dylan W de Lange, Willem J W Bos, Thomas Hankemeier, Ewoudt M W van de Garde, J G Coen van Hasselt

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252378 (2021)

Diagnosis of microbial disease etiology in community-acquired pneumonia (CAP) remains challenging. We undertook a large-scale metabolomics study of serum samples in hospitalized CAP patients to determine if host-response associated metabolites can en

Externí odkaz: https://doaj.org/article/9e963e1a353b43bf9e34f2d05b9ba403

Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling

Autor: Krina Mehta, Tingjie Guo, Piet H. van der Graaf, J. G. Coen van Hasselt

Publikováno v: Clinical Pharmacokinetics. 62:519-532

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4af68d5132069d6514d01a377041765
https://doi.org/10.1007/s40262-023-01217-7

Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling

Autor: Jacqueline J. Meulman, J. G. Coen van Hasselt, Kevin Duisters, Martijn Jansen, Laura B Zwep, Tingjie Guo, Parth J. Upadhyay

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, 10(4), 350-361. Wiley
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 350-361 (2021)

Pharmacometric modeling can capture tumor growth inhibition (TGI) dynamics and variability. These approaches do not usually consider covariates in high‐dimensional settings, whereas high‐dimensional molecular profiling technologies (“omics”)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8556d07fa52692df7b726d959f530aea
http://europepmc.org/articles/PMC8099445

Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors

Autor: Marieke Vinkenoog, Maurice Steenhuis, Anja ten Brinke, J. G. Coen van Hasselt, Mart P. Janssen, Matthijs van Leeuwen, Francis H. Swaneveld, Hans Vrielink, Leo van de Watering, Franke Quee, Katja van den Hurk, Theo Rispens, Boris Hogema, C. Ellen van der Schoot

Publikováno v: Frontiers in Immunology, 13:821721
Frontiers in immunology, 13:821721. Frontiers Media S.A.
Vinkenoog, M, Steenhuis, M, Brinke, A T, Coen van Hasselt, J G, Janssen, M P, van Leeuwen, M, Swaneveld, F H, Vrielink, H, van de Watering, L, Quee, F, van den Hurk, K, Rispens, T, Hogema, B & Ellen van der Schoot, C 2022, ' Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors ', Frontiers in Immunology, vol. 13, 821721 . https://doi.org/10.3389/fimmu.2022.821721

Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f8993bbca7bf5b6fd7a5b9ffbbdf37
http://www.scopus.com/inward/record.url?scp=85126659276&partnerID=8YFLogxK

Biomarker-guided individualization of antibiotic therapy

Autor: Piet H. van der Graaf, Swantje Völler, Mohammed A A Saleh, Linda B. S. Aulin, J. G. Coen van Hasselt, Dylan W. de Lange

Publikováno v: Clinical Pharmacology and Therapeutics, 110(2), 346-360
Clinical Pharmacology and Therapeutics

Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a major clinical challenge, and is expected to become even more urgent with the global rise of antibiotic resistance. Strategies to optimize treatment i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e58f8b3d20c6939770831fad972008a
https://hdl.handle.net/1887/3216835