p53‐dependent up‐regulation of CDKN 1A and down‐regulation of CCNE 2 in response to beryllium

Autor: J. G. Cairncross, Ronald K. Gary, Priyatham Gorjala

Publikováno v: Cell Proliferation. 49:698-709

Objectives Beryllium salts (here, beryllium sulphate) can produce a cytostatic effect in some cell types. The basis for this effect may include increased expression of proliferation inhibitors, reduced expression of proliferation promoters, or both.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0f27408ae2ec6fe97f8e13018403ab
https://doi.org/10.1111/cpr.12291

DRES-04. CHARACTERIZATION OF A MODEL OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA

Autor: J. G. Cairncross, Michael D. Blough, Elizabeth A. Bering, Alice Yuan

Despite the discovery and widespread use of the chemotherapeutic drug temozolomide (TMZ), glioblastoma (GBM) remains a fatal cancer. TMZ, a DNA alkylating agent, provides a moderate survival benefit to patients whose tumours do not express the O6-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6068812291fc2559572dc30bd0a9a568
https://europepmc.org/articles/PMC6216400/

LAB-STEM CELLS

Autor: D. Kozono, M. Nitta, O. Sampetrean, N. Kimberly, D. Kushwaha, D. Merzon, K. Ligon, S. Zhu, K. Zhu, T. H. Kim, C.-H. Kwon, O. Becher, H. Saya, C. C. Chen, L. K. Donovan, S. M. Birks, V. Bosak, G. J. Pilkington, P. Mao, J. Li, K. Joshi, B. Hu, S. Cheng, R. W. Sobol, I. Nakano, M. Li, J. S. Hale, J. T. Myers, A. Y. Huang, C. Gladson, A. A. Sloan, J. N. Rich, J. D. Lathia, P. E. Hall, J. Gallagher, Q. Wu, M. Venere, E. Levy, M. S. Rani, P. Huang, E. Bae, J. Selfridge, L. Cheng, H. Guvenc, R. E. McLendon, A. E. Sloan, H. Phillips, A. Lai, M. Bredel, S. Bao, A. Hjelmeland, M. Sinyuk, P. Sathyan, J. Hale, P. Zinn, C. T. Carson, U. Naik, S. Majumder, L. A. Song, A. Vasanji, N. Tenley, A. B. Hjelmeland, P. Peruzzi, A. Bronisz, E. Antonio Chiocca, J. A. Godlewski, O. A. Guryanova, X. Fang, H.-M. C. Christel, C. Benito, G. Zoltan, B. Aline, S. Tilman, B. Josephine, M. Carolin, S. Thomas, G. Violaine, A. Unterberg, V. Capilla-Gonzalez, H. Guerrero-Cazares, A. Cebrian-Silla, J. M. Garcia-Verdugo, A. Quinones-Hinojosa, J. Man, J. Shoemake, J. Rich, J. Yu, X. He, F. DiMeco, A. L. Vescovi, J. A. Heth, K. M. Muraszko, X. Fan, S. A. Nguyen, O. D. Stechishin, H. A. Luchman, J. J. Kelly, J. G. Cairncross, S. Weiss, Y. Kim, E. Kim, O. O. Guryanova, M. Hitomi, J. Lathia, D. Serwanski, J. Robert, J. Lee, A. Nishiyama, J. K. Liu, W. A. Flavahan, N. Fernandez, M. Wu, S. Das, E. Bazzoli, T. Pulvirenti, M. C. Oberstadt, F. Perna, W. Boyoung, N. Schultz, J. T. Huse, E. I. Fomchenko, F. Voza, V. Tabar, C. W. Brennan, L. M. DeAngelis, S. D. Nimer, E. C. Holland, M. Squatrito, Y.-H. Chen, D. H. Gutmann, S.-H. Kim, M. K. Lee, Y.-J. Chwae, B. C. Yoo, K.-H. Kim, A. Soeda, A. Hara, T. Iwama, D. M. Park, A. Golebiewska, S. Bougnaud, D. Stieber, N. H. Brons, L. Vallar, F. Hertel, R. Bjerkvig, S. P. Niclou, P. Hamerlik, R. Rasmussen, D. Fricova, B. Jiri, A. Schulte, A. Kathagen, S. Zapf, H. Meissner, H. S. Phillips, M. Westphal, K. Lamszus, M. Sanzey, S. K. Singh, A. Vartanian, J. Gumin, E. P. Sulman, F. F. Lang, G. Zadeh, N. S. Bayin, A. Dietrich, T. Abel, M. V. Chao, H.-R. Song, C. J. Buchholz, D. Placantonakis, M. Esencay, D. Zagzag, I. V. Balyasnikova, M. S. Prasol, S. D. Ferguson, A. U. Ahmed, Y. Han, M. S. Lesniak, M. E. Barish, C. E. Brown, K. Herrmann, S. Argalian, M. Gutova, Y. Tang, A. Annala, R. A. Moats, L. Y. Ghoda, K. S. Aboody, S. Gadani, J. Adkins, A. Vsanji, R. McLendon, A. Chenn, D. Park, C. Dictus, S. Friauf, N. A. Valous, N. Grabe, B. Muerle, A. W. Unterberg, C. C. Herold-Mende, H. K. Lee, S. Finniss, E. Buchris, A. Ziv-Av, S. Casacu, C. Xiang, K. Bobbit, S. A. Rempel, T. Mikkelsen, S. Slavin, C. Brodie, D.-H. Woo, Y. Oh, M. Kim, D.-H. Nam, Q. Li, S. Salas, C. Pendleton, O. Wijesekera, D. Chesler, J. Wang, C. Smith, A. Levchenko, Q. LaPlant, K. Pitter, A.-M. Bleau, K. Helmy, J. Werbeck, L. Barrett, F. Shimizu, R. Benezra, E. Holland, Q. Chu, E. Bar, B. Orr, C. G. Eberhart, R. S. Schmid, R. E. Bash, A. M. Werneke, K. K. White, C. R. Miller, F. Agasse, N. Jhaveri, F. M. Hofman, T. C. Chen, A. Natsume, T. Wakabayashi, Y. Kondo, N. Chang, E. Moon, R. Kanai, S. Yip, A. Kimura, S. Tanaka, E. Rheinbay, D. Cahill, W. Curry, G. Mohapatra, J. Iafrate, A. Chi, R. Martuza, S. Rabkin, H. Wakimoto, C. Cusulin, J. A. Frank, A. J. Annala

Publikováno v: Neuro-Oncology. 14:vi142-vi152

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f3d11540e8126662b7e649f3dc5f58
https://doi.org/10.1093/neuonc/nos239

21 Inhibiting PARP-1 to restore temozolomide sensitivity and prevent resistance in glioblastoma

Autor: J. G. Cairncross, A. L. Yuan, E. A. Bering, M. D. Blough

Publikováno v: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 45:S4-S4

Adult Glioblastomas (GBMs) remain one of the least curable brain cancers despite the discovery and use of DNA alkylating agent Temozolomide (TMZ). TMZ provides a moderate survival benefit to sensitive patients whose O6-methylguanine-methyltransferase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb559a611f60183d66266e484ff54066
https://doi.org/10.1017/cjn.2018.309

Hyaluronic Acid Influences Amino Acid Metabolism via Differential L‐Type Amino Acid Transporter 1 Expression in the U87‐Malignant Glioma Cell Line.

Autor: Bale, Ashwin A.¹ (AUTHOR), Thammineni, Swaroop² (AUTHOR), Bhargava, Rohit^1,2,3,4,5 (AUTHOR) rxb@illinois.edu, Harley, Brendan^1,3,5 (AUTHOR) bharley@illinois.edu

Publikováno v: Advanced Nanobiomed Research. Sep2024, p1. 13p. 9 Illustrations.