Výsledky vyhledávání - "J G, Slatter"

Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements

Autor: Howard Monique L, Jan Wahlstrom, J C Tay, Leslie J. Dickmann, J G Slatter, J J Hill, Dan A. Rock, John A. Davis, Josh T. Pearson, Robert S. Foti, Robert J. Greene

Publikováno v: Xenobiotica. 38:264-280

Usnic acid is a component of nutritional supplements promoted for weight loss that have been associated with liver-related adverse events including mild hepatic toxicity, chemical hepatitis, and liver failure requiring transplant. To determine if met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515730668af5c03e6307705ba4fa7c09
https://doi.org/10.1080/00498250701802514

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Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and micein vivo

Autor: Christopher J. Roberts, Roger G. Ulrich, Paul D. Cornwell, Xudong Dai, Thomas H. Rushmore, John C. Castle, Yudong He, A. De Souza, R. Evers, D. Hartley, Michelle J. Caguyong, John C Rockett, Olivia Cheng, R. Hu, J. G. Slatter

Publikováno v: Xenobiotica. 36:902-937

To examine species-specific aspects of the induction of absorption, distribution, metabolism and excretion (ADME)-related genes, we used 25 000 gene oligonucleotide microarrays to construct a rodent gene-response compendium that compared hepatic gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed395f3e55fd2958d56a37d103c67163
https://doi.org/10.1080/00498250600861694

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Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome

Autor: Olivia Cheng, J. G. Slatter, K. Richards, Michelle J. Caguyong, Roger G. Ulrich, Ian Templeton, John C. Castle, Xudong Dai, Amit Kulkarni, Yudong D. He, Thomas H. Rushmore

Publikováno v: Xenobiotica. 36:938-962

Oligonucleotide microarrays were used to study the variability of pharmacokinetics and drug metabolism (PKDM)-related gene expression in 75 normal human livers. The objective was to define and use absorption, distribution, metabolism and excretion (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df2006e6349b0da759b89f15fa0402e
https://doi.org/10.1080/00498250600861728

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Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition

Autor: Roger G. Ulrich, John C. Castle, C.-H. Christina Cheng, Wendy J. Bailey, Jason M. Johnson, Joseph F. Sina, Michael J. Hafey, Kelly Bleasby, J. G. Slatter, Raymond Evers, Christopher J. Roberts, Amit Kulkarni

Publikováno v: Xenobiotica. 36:963-988

Carrier-mediated transporters play a critical role in xenobiotic disposition and transporter research is complicated by species differences and their selective tissue expression. The purpose of this study was to generate a comprehensive data set of x

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728926ee469d851041107f75d7b3a411
https://doi.org/10.1080/00498250600861751

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Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog

Autor: J P Sams, Kenneth L. Feenstra, K. Chiba, S Yamazaki, M R Schuette, N. Ozawa, S Koike, J. G. Slatter, P T Daley-Yates, L A Adams, G. W. Peng, E C Bush

Publikováno v: Xenobiotica. 32:907-924

1. Linezolid (ZYVOX), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections. 2. The aim was to determine the absorption, distribution, metabolism and excretion (ADME) of linezolid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f8fa95fc172b89db3bc048187e732c
https://doi.org/10.1080/00498250210158249

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Metabolism of a bisphosphonate ester (PNU-91638) in rat

Autor: P E Sanders, G. Scott, J. J. Vrbanac, K L Feenstra, W. Speed, J. G. Slatter, M. J. Hauer

Publikováno v: Xenobiotica. 27:1039-1051

1. Metabolites of the cyclic bisphosphonate ester, 4-[2,2'-bis-(5,5- dimethyl-1,3,2-dioxaphosphorinan-2-yl)] butanoyl-3-fluoro-benzene (PNU-91638) in bile or urine of the male Sprague-Dawley rat were characterized by mass spectrometry. The chronicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e976bf16fd1ed9de0e9d3eb6c0ede52a
https://doi.org/10.1080/004982597240019

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Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate

Autor: Mohamed S. Rashed, Thomas A. Baillie, Paul G. Pearson, Deog-Hwa Han, J. G. Slatter

Publikováno v: Chemical Research in Toxicology. 4:436-444

The reactivity toward peptides and proteins of S-(N-methylcarbamoyl)glutathione (SMG), the glutathione conjugate of methyl isocyanate, and the corresponding cysteine adduct, S-(N-methylcarbamoyl)cysteine (SMC), was investigated with the aid of in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701efb4930f99b12995cb71ca82b6475
https://doi.org/10.1021/tx00022a007

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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

Autor: Deog-Hwa Han, Mohamed S. Rashed, Paul G. Pearson, Thomas A. Baillie, J. G. Slatter

Publikováno v: Chemical Research in Toxicology. 4:157-161

S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry (LC-MS) in the urine of rats dosed intraperitoneally with methyl isocyanate (MIC; 45.2 mumol). Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e1304cfd5a4b7a8ac1c61dc6bfd0c
https://doi.org/10.1021/tx00020a006

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[Untitled]

Autor: Thomas A. Baillie, Alan V. Boddy, Francis Lepage, F. Tombret, RenéH. Levy, J. G. Slatter, Kanyin Zhang

Publikováno v: Pharmaceutical Research. :690-697

A dihydropyridine-based chemical delivery system (CDS), intended to improve drug delivery to the brain, was investigated with a series of analogues of the anticonvulsant stiripentol. In vitro experiments demonstrated that the rates of hydrolysis of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33d770d4617bfcd6beb62db3a86c264a
https://doi.org/10.1023/a:1015885530405

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