Zobrazeno 1 - 7
of 7
pro vyhledávání: '"J G, Shaddock"'
Autor:
J. G. Shaddock, Daniel A. Casciano
Publikováno v:
Journal of Tissue Culture Methods. 15:49-54
Primary hepatocyte cultures provide a unique system for studying hepatic drug metabolism and liver toxicity from exposure to xenobiotics. Major difficulties associated with hepatocyte cultures have been the time-dependent decline in levels of drug-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92fb414f1998c3738f86ddd3776fc079
https://doi.org/10.1007/bf02387290
https://doi.org/10.1007/bf02387290
Autor:
S M, Morris, J L, Pipkin, W G, Hinson, J G, Shaddock, W H, Tolleson, J F, Young, D A, Casciano
Publikováno v:
Electrophoresis. 22(10)
In a previous study, the strength of the interaction between the nuclear stress proteins (sps) 25a, 70i, 72c, and 90 and the tumor suppressor protein p53 was determined by an in vitro fluorescence binding assay. The relative binding of the individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbb5ec6dbf46ab399c90b46d411b17f9
https://pubmed.ncbi.nlm.nih.gov/11465510
https://pubmed.ncbi.nlm.nih.gov/11465510
Publikováno v:
Environmental and molecular mutagenesis. 36(4)
7,12-Dimethylbenz[a]anthracene (DMBA) is a rodent carcinogen and a potent in vivo mutagen for the X-linked hypoxanthine guanine phosphoribosyl transferase (hprt) gene of rats and for the lacI transgene of Big Blue mice and rats. Although DMBA is also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22adcb4c78c0f7d1eb7f878321503a54
https://pubmed.ncbi.nlm.nih.gov/11152561
https://pubmed.ncbi.nlm.nih.gov/11152561
Publikováno v:
Carcinogenesis. 15(8)
The potent rat colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), unlike other food-borne heterocyclic amines, does not induce tumors in rat liver. This correlates with an extremely low level of PhIP-DNA adducts formed in this t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b875672eef3256226b3135dce5b6f4ae
https://pubmed.ncbi.nlm.nih.gov/8055653
https://pubmed.ncbi.nlm.nih.gov/8055653
Publikováno v:
Cell biology and toxicology. 9(4)
The effects of cryopreservation and long-term storage on substrate-specific cytochrome P450-dependent activities and unscheduled DNA synthesis were studied in freshly isolated and cryopreserved hepatocytes derived from adult male Fischer 344 and Spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7928087de13dcf2e01723e064b9f5453
https://pubmed.ncbi.nlm.nih.gov/8039011
https://pubmed.ncbi.nlm.nih.gov/8039011
Publikováno v:
Biomedical and environmental sciences : BES. 4(1-2)
Laboratory animals maintained on a reduced calorie but nutritionally adequate diet have extended life spans and lowered incidences of spontaneous and chemically induced cancers compared to ad libitum- fed counterparts. Many of the effects of dietary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91287650661ce81df10cf3f87bc26b1a
https://pubmed.ncbi.nlm.nih.gov/1910591
https://pubmed.ncbi.nlm.nih.gov/1910591
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 11(3)
Since the herbicide propanil (3,4-dichloropropionanilide) is an aromatic amide and many other aromatic amides are genotoxic via N-hydroxy (N-OH) metabolites, N-oxidized derivatives of propanil and 3,4-dichloroaniline were synthesized and tested for g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfc49fca9aed9359ff0c686f2c2ec37
https://pubmed.ncbi.nlm.nih.gov/3065118
https://pubmed.ncbi.nlm.nih.gov/3065118