Výsledky vyhledávání - "J G, Sathish"

Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M

Autor: N R, Catlin, C J, Bowman, S N, Campion, J R, Cheung, W S, Nowland, J G, Sathish, C M, Stethem, L, Updyke, G D, Cappon

Publikováno v: Reproductive Toxicology (Elmsford, N.y.)

Nirmatrelvir (PF-07321332; NMV) the antiviral component of PAXLOVID™ is a potent and selective inhibitor of the SARS-CoV-2 main protease (Mpro), which plays a critical role in viral replication. PAXLOVID, comprised of nirmatrelvir and ritonavir (us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8cf277e0aa37bda945307af72fac89c
https://pubmed.ncbi.nlm.nih.gov/35101563

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alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice

Autor: L E, Randle, J G, Sathish, N R, Kitteringham, I, Macdonald, D P, Williams, B K, Park

Publikováno v: British journal of pharmacology. 153(4)

Paracetamol, a major cause of acute liver failure (ALF) represents a significant clinical problem. Adrenoceptor stimulation or antagonism can modulate chemical-induced hepatotoxicity. We investigated the role of endogenous catecholamines and alpha(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b3d170235861c58351186cdcfe6c604
https://pubmed.ncbi.nlm.nih.gov/18071297

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