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pro vyhledávání: '"J G, Pace"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(1)
The distribution, excretion and hepatic metabolism of [3H]microcystin-LR (sublethal i.v.) were measured in mice. Plasma elimination was biexponential with alpha- and beta-phase half-lives of 0.8 and 6.9 min, respectively. At 60 min, liver contained 6
Autor:
J G, Pace
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 7(3)
Isolated perfused rat livers were used to study the metabolism and clearance of T-2 mycotoxin, a nonprotein Fusarium metabolite known to cause illness or death on contact or by ingestion. To evaluate the in vitro hepatic metabolism, clearance, and ra
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 7(3)
Discs of abdominal skin (obtained from humans and hybrid monkeys at autopsy) were mounted on diffusion cells. The epidermal surfaces were dosed with [3H]T-2 dissolved in dimethyl sulfoxide (DMSO). The rate of [3H]T-2 penetration (expressed as ng/cm2/
Publikováno v:
Journal - Association of Official Analytical Chemists. 70(4)
A standard radioimmunoassay was compared with radiochromatography for the ability to detect unlabeled T-2 mycotoxin in organs from exposed animals. When 10% of HT-2, the only known metabolite that cross-reacts with T-2, was included and expressed as