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pro vyhledávání: '"J G, Deal"'
Autor:
S E, Webber, T M, Bleckman, J, Attard, J G, Deal, V, Kathardekar, K M, Welsh, S, Webber, C A, Janson, D A, Matthews, W W, Smith
Publikováno v:
Journal of medicinal chemistry. 36(6)
The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out by a repetitive crystallographic analysis of protein-ligand structures. At the onset of this