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Biotransformation of clozapine in humans

Autor: J G, Dain, J, Nicoletti, F, Ballard

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(5)

The metabolic pathways of clozapine (CZ, Clozaril (Novartis Pharmaceuticals Corporation, East Hanover, NJ), 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo [b,e][1,4]diazepine, a tricyclic benzodiazepine neuroleptic which has a reduced risk of unwant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f96d1b5e142894c9d19b06d3c811563
https://pubmed.ncbi.nlm.nih.gov/9152600

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Metabolic pathways of 4-[(3-methoxyphenyl)methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2,6- disilacyclohexane (MPSC) hydrochloride, a silicon-containing xenobiotic, in rat, dog, and man

Autor: J G, Dain, J, Nicoletti

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 25(9)

1. The metabolic pathways of Sandoz compound 58-112, 4-[(3-methyoxyphenyl)-methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2,6- disilacyclohexane (MPSC) hydrochloride were evaluated in rat, dog, and man after a single oral dose. 2. In rat, dog and man the ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e280211e08044c21ea5c3bae4a7de53e
https://pubmed.ncbi.nlm.nih.gov/8553688

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A regulatory and industrial perspective of the use of carbon-14 and tritium isotopes in human ADME studies

Autor: J G, Dain, J M, Collins, W T, Robinson

Publikováno v: Pharmaceutical research. 11(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::781455aae71ffb679788343e3ae1cab2
https://pubmed.ncbi.nlm.nih.gov/7937538

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Biotransformation of fluvastatin sodium in humans

Autor: J G, Dain, E, Fu, J, Gorski, J, Nicoletti, T J, Scallen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(4)

The metabolic pathways of fluvastatin sodium (FV; Lescol, Sandoz compound XU 62-320), [R*,S*-(E)]-(+-)-sodium-3,5-dihydroxy-7-[3- (4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-yl]-hept-6-enoate, a potent inhibitor of hydroxy-methylglutaryl-CoA reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::645cfdda71c785946ad9cd4cd7fb5f10
https://pubmed.ncbi.nlm.nih.gov/8104114

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Pharmacokinetics and metabolism of α-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man

Autor: Francis L. S. Tse, J. M. Jaffe, J. G. Dain, B. A. Orwig

Publikováno v: Xenobiotica. 17:1259-1267

1. The pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl) -1H-[3-14C]indole-3-methanol, a new hypoglycemic agent, have been studied in 15 healthy male volunteers who received an oral dose of 50 or 200 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5d3746a1f9849f53d0ae4d62f43441
https://doi.org/10.3109/00498258709167417

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Effect of diet and gavage on the absorption and metabolism of fluperlapine in the rat

Autor: J G, Dain, J M, Jaffe

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 16(2)

Fluperlapine, Sandoz compound NB 106-689, 3-fluoro-6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine, in a 12-week toxicity study exhibited liver toxicity (moderate to severe hyperlipidosis) when administered to rats in the diet at 40 mg/kg/day and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af7ac302c4f2e64e1963910785047d29
https://pubmed.ncbi.nlm.nih.gov/2898340

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Metabolism of butalbital, 5-allyl-5-isobutylbarbituric acid, in the dog

Autor: J G, Dain, S I, Bhuta, R A, Coombs, K C, Talbot, H A, Dugger

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 8(4)

Butalbital, 5-allyl-5-isobutylbarbituric acid, labeled in the 2-position with 14C, was administered to dogs. Ninety-two percent of the radioactivity of the dose was excreted in the urine. The drug and three major urinary metabolites were identified i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2365d329c08a0c70bf1b774a6388322d
https://pubmed.ncbi.nlm.nih.gov/6105059

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