Zobrazeno 1 - 10
of 22
pro vyhledávání: '"J G, Christenson"'
Autor:
Fred Konzelmann, Harry Allen Albrecht, Chung Chen Wei, G. Beskid, J. G. Christenson, N H Georgopapadakou, Dennis D. Keith, David L. Pruess, K. H. Deitcher
Publikováno v:
Journal of Medicinal Chemistry. 37:400-407
We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual mode of antibacterial action. We now describ
Autor:
Harry Allen Albrecht, Dennis D. Keith, J. G. Christenson, Chung-Chen Wei, Konzelmann Frederick Martin, N H Georgopapadakou, G. Beskid, Rossman Pamela Loreen, David L. Pruess
Publikováno v:
ChemInform. 23
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reporte
Autor:
V. Fallat, J. Siebelist, D. H. Mcgarry, Manfred Weigele, Roxana Yang, Dennis D. Keith, G. Beskid, N H Georgopapadakou, J. W. Durkin, E. R. Lipschitz, Konzelmann Frederick Martin, Chung-Chen Wei, Harry Allen Albrecht, J. G. Christenson
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
The synthesis and β-lactamase inhibiting properties of 2,3-α-methylenepenicillanic acid sulfone (3) are described. The results presented are consistent with previous work indicating that β-lactamases recognize α-methylenepenams as cephalosporins.
Autor:
N H Georgopapadakou, Chung Chen Wei, Dennis D. Keith, G. Beskid, J. G. Christenson, Fred Konzelmann, Harry Allen Albrecht, K. H. Deitcher, David L. Pruess
Publikováno v:
ChemInform. 25
We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual mode of antibacterial action. We now describ
Autor:
David L. Pruess, Konzelmann Frederick Martin, Dennis D. Keith, Harry Allen Albrecht, Rossman Pamela Loreen, Chung-Chen Wei, J. G. Christenson, N H Georgopapadakou, G. Beskid
Publikováno v:
Journal of Medicinal Chemistry. 34:2857-2864
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reporte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:43-46
The synthesis and β-lactamase inhibiting properties of 2,3-α-methylenepenicillanic acid sulfone (3) are described. The results presented are consistent with previous work indicating that β-lactamases recognize α-methylenepenams as cephalosporins.
Autor:
A Specian, B Dix-Holzknecht, J. G. Christenson, H H Farrish, Chan Ka-Kong, Indravadan H. Patel, Roy Cleeland
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1895-1900
Ro 23-9424 is a dual-action cephalosporin with an aminothiazolylmethoxyimino-type side chain at the 7 position and fleroxacin esterified at the 3' position. The new compound has broad and potent antibacterial activity in vitro and in vivo, reflecting
Autor:
Sepinwall J, R. Cleeland, Chan Ka-Kong, J. G. Christenson, Dennis D. Keith, Harry Allen Albrecht, G. Beskid, K. H. Deitcher, N H Georgopapadakou, David L. Pruess
Publikováno v:
Journal of Medicinal Chemistry. 33:77-86
According to the generally accepted mechanism by which bacterial enzymes react with cephalosporins, opening of the beta-lactam ring can lead to the expulsion of a 3'-substituent. A series of dual-action cephalosporins was prepared in which antibacter
Autor:
H A, Albrecht, G, Beskid, J G, Christenson, J W, Durkin, V, Fallat, N H, Georgopapadakou, D D, Keith, F M, Konzelmann, E R, Lipschitz, D H, McGarry
Publikováno v:
Journal of medicinal chemistry. 34(2)
When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the beta-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked