Zobrazeno 1 - 10
of 251
pro vyhledávání: '"J Flavell"'
Autor:
Jennifer Jones, Felicity Evison, Richard Lilford, Celia Brown, Julian Bion, Carolyn Tarrant, A Joshi, J Mann, Ivo Vlaev, Stephen E Wright, Daniel Wolstenholme, Ian Clement, C Scott, Gavin Perkins, J Thompson, Paul Sullivan, Chris Gibbins, Fang Gao Smith, Catherine Snelson, L Cooper, T Jones, Randeep Mullhi, Julian Archer, H Halliday, Olivia Brookes, Duncan Buckley, Lisa Marie Buckley, Emma Hayton, Greg Packer, Jonathan Shelton, J Willars, C Higenbottam, F Wyton, E Fellows, K Moss, L Flavell, J Flavell, J Raeside, M Hawkesford, H Laugher, S Nevitt, K Naylor, J Sampson, S Ballinger, T Melody, G Buggy, S Majid, P Diviyesh, P Thorpe, A Shaha, R Carvell, K Kneller, C Iles, I O’Neil, G Yeoman, C Randell, H Korovesis, H Doherty, K Protheroe, E Swann, L Dunn, K Mccourt, S Perks, T Chakravorty, C Grindell, R Bec
Publikováno v:
BMJ Open, Vol 9, Iss 7 (2019)
Introduction Patient and staff experiences are strongly influenced by attitudes and behaviours, and provide important insights into care quality. Patient and staff feedback could be used more effectively to enhance behaviours and improve care through
Externí odkaz:
https://doaj.org/article/e597d108ef24404785a6f47440de4e96
Autor:
David J. Flavell, Sopsamorn U. Flavell
Publikováno v:
Toxins, Vol 14, Iss 8, p 563 (2022)
Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The targeting domain of the TT recognises and binds to a defined target molec
Externí odkaz:
https://doaj.org/article/de77de23d95743df98af6c2712fe99c9
Autor:
Hazel Bull, M. Cristina Casao, Monika Zwirek, Andrew J. Flavell, William T. B. Thomas, Wenbin Guo, Runxuan Zhang, Paulo Rapazote-Flores, Stylianos Kyriakidis, Joanne Russell, Arnis Druka, Sarah M. McKim, Robbie Waugh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The VRS genes of barley control the fertility of the lateral spikelets on the barley inflorescence. Here, Bull et al. show that VRS3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other VRS genes, and genes involve
Externí odkaz:
https://doaj.org/article/3c947adfbf2e4630b05fcf54e1657403
Autor:
Mathias Wiegmann, Andreas Backhaus, Udo Seiffert, William T B Thomas, Andrew J Flavell, Klaus Pillen, Andreas Maurer
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224491 (2019)
Hyperspectral imaging enables researchers and plant breeders to analyze various traits of interest like nutritional value in high throughput. In order to achieve this, the optimal design of a reliable calibration model, linking the measured spectra w
Externí odkaz:
https://doaj.org/article/d64725e8cb5e4ea594285bd39f493094
Autor:
Harrison J. Wensley, Wendy S. Smith, Suzanne E. Holmes, Sopsamorn U. Flavell, David J. Flavell
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 300 (2021)
Triterpenoid saponins augment the cytotoxicity of saporin based immunotoxins. It is postulated that this results from a saponin-mediated increase in the endolysosomal escape of the toxin to the cytosol, but this remains to be confirmed. To address th
Externí odkaz:
https://doaj.org/article/cfc870a754924067a6d2bd4d265023b0
Autor:
Xin Xu, Rajiv Sharma, Alessandro Tondelli, Joanne Russell, Jordi Comadran, Florian Schnaithmann, Klaus Pillen, Benjamin Kilian, Luigi Cattivelli, William T. B. Thomas, Andrew J. Flavell
Publikováno v:
The Plant Genome, Vol 11, Iss 1 (2018)
A collection of 379 Hordeum vulgare cultivars, comprising all combinations of spring and winter growth habits with two and six row ear type, was screened by genome wide association analysis to discover alleles controlling traits related to grain yiel
Externí odkaz:
https://doaj.org/article/a24070a13eab42b29de8f04ff63ff159
Publikováno v:
Biomedicines, Vol 7, Iss 1, p 13 (2019)
We have previously shown that antibody-dependent cellular cytotoxicity (ADCC) cooperates with immunotoxin (IT)-mediated killing of human leukaemia cells in an severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic leuk
Externí odkaz:
https://doaj.org/article/029166a7392345ce939693a9866fc006
Autor:
Wendy S. Smith, David A. Johnston, Suzanne E. Holmes, Harrison J. Wensley, Sopsamorn U. Flavell, David J. Flavell
Publikováno v:
Toxins, Vol 11, Iss 2, p 127 (2019)
Triterpenoid saponins from Saponinum album (SA) significantly augment the cytotoxicity of saporin-based immunotoxins but the mechanism of augmentation is not fully understood. We investigated the effects of six small molecule pharmacological agents,
Externí odkaz:
https://doaj.org/article/833679c267eb49f9bde90e8bb95ed9a9
Publikováno v:
Antibodies, Vol 2, Iss 2, Pp 209-235 (2013)
Membranes are vital barriers by which cells control the flux of molecules and energy between their exterior and interior and also between their various intracellular compartments. While numerous transport systems exist for ions and small molecules, t
Externí odkaz:
https://doaj.org/article/eb421a547a434a5d9c38a106dcbd8ef0
Autor:
Maria Serena Fabbrini, Sopsamorn U. Flavell, David J. Flavell, Riccardo Vago, Valeria Giordani, Francesco Giansanti, Rodolfo Ippoliti
Publikováno v:
Antibodies, Vol 2, Iss 1, Pp 50-65 (2013)
Elucidating the intracellular fate(s) of targeted toxins is of fundamental importance for their optimal use as anticancer drugs, since the biochemical targets of their enzymatic activity reside in the cell cytoplasm, as in the case of the plant ribos
Externí odkaz:
https://doaj.org/article/ce17f5712b0c42e9bce74e619dd0df3f